rojjer 发表于 2016-1-7 13:32:34

【专家讲坛】卢洪洲教授谈人感染H5N6禽流感及其防控

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


近日我国广东连续出现两例人感染H5N6禽流感病例,就网友关心的问题,健康报记者张磊采访了上海市公共卫生临床中心卢洪洲教授。

张磊:目前全球已发现了6例H5N6病例,为何全部出现在我国?这是否与人种相关?如果与人种无关,又该如何解释?此外,目前仅有广东、四川和云南出现了病例,从地理分布上看,是否有关联性?
卢洪洲教授:国外也有报道,包括我们的邻国越南也分离出该病毒的报道,但是,我国大陆分离到的H5N6病毒亚型为高致病性,现有的资料只能说明病毒致病性增高而非与人种有关,尽管目前死亡病例仅限于我们国家,但是相互之间无流行病学关联,均是散发个案。

张磊:资料显示,2014年出现了我国2例H5N6,2015年出现了3例,而今年年初就已经出现了1例,这是否意味着H5N6有可能在今年存在现集中暴发的可能?
卢洪洲教授:不可能暴发,因为没有证据显示该病毒具备人间传播的能力。我国的不明原因肺炎传报体系健全,个别病例也能及时发现。

张磊:这次深圳的患者从入院到死亡仅仅2天,病情进展非常快,这能否说明H5N6比H7N9更为凶险?在患者的救治方面,目前采取的是哪些措施?是否有特效药,还是仅仅做对症治疗?
卢洪洲教授:死亡患者出现重症才进行相关检测,故不是早期发现。没有及时应用特效抗流感病毒药物奥司他韦是关键因素。

张磊:甲型流感病毒是依据病毒表面的血细胞凝集素(H)和神经氨酸酶(N)来命名,截至目前共发现H有18个亚型,N有11个亚型,就是说会有198种组合,那么目前已发现的有多少种组合?在致病强度方面是否有规律?
卢洪洲教授:甲型流感病毒根据病毒表面的2个蛋白:血凝素(H)和神经氨酸酶(N)。血凝素有18个不同的亚型(H1-H18)和神经氨酸酶有11个不同的亚型(N1-N11)。理论上是有如此多的亚型,但是,目前鉴定出的亚型仅是少部分,仍有众多亚型会不断出现,不同亚型致病性不同,我们只有等到其新亚型出现才能明确致病性强弱。目前发现除了甲型流感病毒H17N10亚型和H18N11亚型仅感染蝙蝠外,所有已知的其他甲型流感病毒亚型都可以感染鸟类。只有两个甲型流感病毒亚型(即H1N1亚型和H3N2亚型)目前正在人群中流行。其他甲型流感病毒亚型可以感染动物,导致动物生病,例如H7N7亚型和H3N8亚型病毒感染马、H3N8亚型病毒感染狗。

张磊:深圳市疾控中心发布的消息显示,此次深圳发现感染人的基因来源比较复杂,至少经历H5N1流感病毒与H6N6流感病毒的重配,然后重配的H5N6流感病毒再与H9N2流感病毒重配,产生目前感染人的H5N6流感病毒。如何对这一结果进行解读?是否说明病毒重配越发频发,人类对其越发失去了控制力?
卢洪洲教授:病毒重配是其自然规律,新病毒出现需要时间与空间环境条件,其中人-禽密切接触是病毒重配的常见原因,所以,关闭活禽市场、科学改造禽类养殖-流通方式不仅可以预防禽流感,而且可以有效预防新型流感病毒的出现。新病毒出现,我们以往没有相应的抗体,则容易发病。

张磊:目前H5N6是否有人传人的可能?检测试剂的研发是何情况?
卢洪洲教授:目前无人间传播,检测仍是核酸序列分析。

张磊:是否有研发相应疫苗的可能性和必要性?如果不必研发疫苗,那么公众选择何种方式就可最大限度的避免被感染?
卢洪洲教授:个案病例发生我们仍要提高警惕,可以储备疫苗研发的技术,但是,目前没有必要生产该疫苗。大家要养成良好的卫生习惯,尤其不要与活禽接触。




高致病性和低致病性甲型禽流感病毒简介
甲型禽流感病毒是指根据在实验室条件下病毒的分子特征及其引起鸡发病和死亡的能力,分为高致病性禽流感(HPAI)病毒或低致病性禽流感(LPAI)病毒。
低致病性禽流感 病毒感染家禽后,可会导致家禽不生病或轻微疾病(如羽毛粗乱和产蛋量下降)而不易被觉察到。高致病性禽流感病毒感染禽类后,可引起禽类严重的疾病和高死亡率。高致病性禽流感病毒和低致病性禽流感病毒都可以通过家禽迅速传播。鸡感染高致病性禽流感病毒后,可以引起多个内脏器官的损害,通常在48小时内病死率高达90 - 100%。然而,鸭子感染后可没有任何症状。不同甲型禽流感病毒亚型有基因和抗原差异,有的亚型通常只感染鸟类,有的亚型既可以感染鸟类,也可以感染人。
有三个大家已经熟知的同时感染鸟类和人的甲型禽流感病毒亚型:
1.甲型禽流感H5病毒:H5病毒有9个亚型 (H5N1、H5N2、H5N3、H5N4、H5N5、H5N6、H5N7、H5N8和H5N9)。全世界大多数已发现的H5亚型病毒在野生鸟类和家禽体内是低致病性病毒,但偶尔发现是高致病性病毒。散发的H5亚型病毒,如已有报告目前在亚洲和中东的16个国家的家禽中流行的亚洲来源的高致病性禽流感病毒(H5N1),感染人类后,常导致严重肺炎,全球病死率约为60%。
2.甲型禽流感H7病毒:已知有H7病毒有9个亚型(H7N1、H7N2 、H7N3、H7N4 、H7N5、H7N6、H7N7、H7N8和H7N9)。全球大多数H7亚型病毒在野生鸟类和家禽是低致病性病毒。H7亚型病毒感染人类是不常见的,但已经有记载人类因直接接触受H7亚型病毒感染的鸟类,特别是在禽类H7亚型病毒感染暴发期间而感染。人类感染H7亚型病毒后可引起结膜炎和/或上呼吸道症状。在人类,低致病性禽流感病毒(H7N2 、H7N3和H7N7)感染可引起轻至中度的疾病。高致病性禽流感病毒H7N3和H7N7感染可引起轻微到严重甚至致命的疾病。2013年4月1日,中国报道第一个已知的人感染禽流感病例H7N9病毒,与严重呼吸道疾病和死亡相关。

3.甲型禽流感H9病毒
H9病毒有9个已知的亚型(H9N1、H9N2、H9N3、H9N4、H9N5、H9N6、H9N7、H9N8和H9N9),全球所有野生鸟类和家禽中的H9病毒都是低致病性病毒。在亚洲、欧洲、中东和非洲的鸟类中发现H9N2病毒。已有罕见、散发的H9N2病毒感染人类的报告,通常引起轻微上呼吸道疾病。


卢洪洲教授简介:



卢洪洲,主任医师、教授、内科学博士、留美博士后、内科学博士生导师、护理学硕士生导师,著名传染病防控专家,享受国务院特殊津贴。现任上海市(复旦大学附属)公共卫生临床中心党委书记兼感染科主任,复旦大学附属华山医院院长助理,传染病科主任。曾先后入选国家百千万人才工程、“有突出贡献中青年专家”、上海领军人才”、“上海市优秀学科带头人”和“上海市医学领军人才”等。卢洪洲教授以第一作者或通讯作者在国内外发表各类论文360余篇,其中在国际权威杂志包括《New England Journal of Medicine》、《Emerging Infectious Diseases》、《AIDS》等杂志上发表论著90余篇并担任多个国际重要学术期刊的编委和审稿人;主编专业参考书10本、副主编专著8部。已获8项省部级科技成果奖、获专利4项。先后承担国家传染病重大专项、 “十二五”重大新药创制平台、“863”、“973”(子课题)、国家自然科学基金、上海市科委基金、美国盖茨基金、美国NIH项目、国家临床重点专科等30余项科研课题。卢洪洲教授作为著名传染病防控专家积极参与了乙肝、艾滋病、SARS、高致病性禽流感、09甲流、H7N9禽流感和埃博拉等多种重大新发和再现传染病疫情的临床诊疗、科学研究及国家疫情防治策略制定等各项工作。先后荣获全国医药卫生系统先进个人、全国抗击“非典”先进个人、中国医药科技创新人物、团中央与全国学联“中国大学生跨世纪发展奖励基金”;上海市卫生系统 “银蛇奖”、文明职工、“创新之星”;上海市卫生局先进工作者并行政记大功一次、上海市科委“明治乳业科学奖”;美国肝病学会-亚太肝病学会奖、艾滋病国际倡导联盟“精忠奖”。2014年,作为中国首批援塞拉利昂公共卫生师资培训队的医学专家,并担任培训队临时党支部副书记,因其做出的巨大贡献获得了“影响中国”2014年度科技人物的盛誉,并于2015年3月获“最美援外医生”殊荣。
卢洪洲教授业务擅长:发热待查;抗菌药物合理应用;中枢神经系统感染、呼吸系统感染、肝炎、艾滋病、寄生虫等感染性疾病的诊治;主要研究方向:感染性疾病的诊治与发病机制研究。
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