rojjer 发表于 2015-6-5 11:19:39

一滴血,揭秘你和病毒的恋情史

一种叫做VirScan的新技术只需不到一滴血的量便能确定一个人在其一生中所接触过的所有病毒。最近Science new发布了该项研究成果。 研究人员对来自世界各地569人使用了该筛检技术并发现,平均而言,他们的实验参与者在其一生中接触过大约10种病毒。VirScan为研究人类病毒组(已知会感染人的各种病毒汇集)和免疫系统(它会因接触 病毒而永久性地改变)之间的相互作用提供了一个强有力而且廉价的工具。
data:image/png;base64,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


在此之前,用来检测病毒遗留下来的无法抹灭足迹的血液化验(即免疫系统所分泌的抗体)受到了其所能筛检病毒数目的限制。
为了扩大这些化验所能涵盖的范围,George Xu和同事用采自206种病毒的一个大型病毒肽数据集(它代表了1000多不同的病毒株)创建了一个所有人类病毒肽的综合代表。用这一模板,他们能筛检血样本中的病毒抗体,而每个样本的筛检价格只要25美元。这些来自不同研究参与者(他们来自4个不同的大陆)的样本揭示了超过1.06亿种肽-抗体相互作用。多人接触过大约10种病毒,但至少有一些志愿者接触过84种病毒。
这些发现凸显了保守的免疫应答(或称“公共抗原表位”)并表明个人可能会因应相同的病毒而分泌类似的抗体--尽管人们接触病毒的比率是大相径庭的。Xu和他的同事提出,VirScan的精度可用更多的血样本来提高,且未来它可能还会适用于细菌、真菌或原生动物。
原文链接:New test could reveal every virus that's ever infected you
http://news.sciencemag.org/biology/2015/06/new-test-could-reveal-every-virus-thats-ever-infected-you
页: [1]
查看完整版本: 一滴血,揭秘你和病毒的恋情史