病毒学领域优秀研究生导师系列之一：曹志贱教授
曹志贱/Zhijian Cao
http://www.bio.whu.edu.cn/UploadFile/201568195855896.jpg
职 称：教授、博士、国家优秀青年基金获得者
Professor, PhD
学科专业：微生物学/病毒学
研究方向：病毒感染及其防治
实验室位置：生命科学学院大楼5114房间
联系电话/Tel： 86-27-68756746(Lab)
Email: zjcao@whu.edu.cn
教育经历/Education：
1999/09-2004/06，武汉大学，博士/WuhanUniversity, PhD
1994/09-1998/07，武汉大学，学士/WuhanUniversity, Bachelor's Degree
工作经历/Professional Experience：
2004/07-至今：武汉大学生命科学学院/College of Life Sciences, Wuhan University
2014/02-2015/01：美国梅哈里医学院/Meharry Medical College, USA
1998/07-1999/08： 湖南省畜牧兽医研究所/Animal husbandry and veterinary institute of Hunan province
研究方向/Research Fields：
1) 病毒感染及其防治/Viral infection, prevention and cure
2) 抗病原微生物多肽的药用基础/Medicinal basis of peptides against pathogen viruses and bacteria
3) 毒素多肽生物学/Toxic peptide biology
基金资助/Fund support：
1) 国家优秀青年基金：蝎毒素遗传资源的保护、认识与利用研究
2) 湖北省杰出青年基金：靶向抗肿瘤蝎氯毒素的药用基础研究
3) 中央高校基本科研基金：蝎毒素多肽的药用基础研究
研究概述/Research Description：
我过去以蝎为代表开展毒素多肽生物学研究，创建了蝎毒素多肽资源库，发现了蝎毒素多肽的分子多样性，首绘了蝎全基因组图谱，揭示了蝎毒素多肽分子多样性的产生机制，发掘了蝎毒素多肽的抗肿瘤、抗菌、抗病毒功能及作用机制，开拓了蝎毒素多肽研究和药用新领域。现在主要开展离子通道在病毒感染中作用以及在此基础上抗病毒多肽的筛选与设计研究。/ Before, I focused on the biology of toxin peptides (e.g. scorpion), involving in the library construction, diversity and its mechanism, pharmacological roles and their mechanisms of scorpion toxins. Today, I am interesting in the functions of ion channels in the infections of viruses, and then the discovery of antiviral peptides.
代表性学术论文/ Selected Publications：
1) Song Y, Gong K, Yan H, Hong W, Wang L, Wu YL, Li WH*, Li WX*, Cao ZJ*. (2014). Sj7170, a unique dual-functional peptide with a specific α-chymotrypsin inhibitory activity and a potent tumor activating effect from scorpion venom. J Biol Chem. 289(17):11667-80.
2) Cao Z#, Yu Y#, Wu Y#, Hao P#, Di Z#, He Y#, Chen Z, Yang W, Shen Z, He X, Sheng J, Xu X, Pan B, Feng J, Yang X, Hong W, Zhao W, Li Z, Huang K, Li T, Kong Y, Liu H, Jiang D, Zhang B, Hu J, Hu Y, Wang B, Dai J, Yuan B, Feng Y, Huang W, Xing X, Zhao G, Li X, Li Y, Li W. (2013). The genome of Mesobuthus martensii reveals a unique adaptation model of arthropods. Nat Commun. 4:2602.
3) Hong W, Zhang R, Di Z, He Y, Zhao Z, Hu J, Wu Y, Li W, Cao Z*. (2013). Design of histidine-rich peptides with enhanced bioavailability and inhibitory activity against hepatitis C virus. Biomaterials. 34(13):3511-3522.
4) He Y, Zhao R, Di Z, Li Z, Xu X, Hong W, Wu Y, Zhao H, Li W, Cao Z*. (2013). Molecular diversity of Chaerilidae venom peptides reveals the dynamic evolution of scorpion venom components from Buthidae to non-Buthidae. J Proteomics. 89:1-14.
5) Zhao Z, Hong W, Zeng Z, Wu Y, Hu K, Tian X, Li W*, Cao Z*. (2012). Mucroporin-M1 inhibits Hepatitis B virus replication by activating the mitogen-activated protein kinase (MAPK) Pathway and down-regulating HNF4α in vitro and in vivo. J Biol Chem. 287(36):30181-30190.
6) Fan Z, Cao L, He Y, Hu J, Di Z, Wu Y, Li W*, Cao Z*. (2011). Ctriporin, a new anti-methicillin-resistant Staphylococcus aureus peptide from the venom of the scorpion Chaerilus tricostatus. Antimicrob Agents Chemother. 55(11):5220-5229.
7) Yu XF, Sun Z, Li M, Xiang Y, Wang QQ, Tang F, Wu Y, Cao Z*, Li W*. (2010). Neurotoxin-conjugated upconversion nanoprobes for direct visualization of tumors under near-infrared irradiation. Biomaterials. 31(33): 8724-8731.
8) Di Z, Yu Y, Wu Y, Hao P, He Y, Zhao H, Li Y, Zhao G, Li X*, Li W*, Cao Z*. Genome-wide analysis of homeobox genes from Mesobuthus martensii reveals Hox gene duplication in scorpions. Insect Biochem Mol Biol. 2015 Jun;61:25-33.
9) Hong W, Li T, Song Y, Zhang R, Zeng Z, Han S, Zhang X, Wu Y, Li W, Cao Z*. Inhibitory activity and mechanism of two scorpion venom peptides against herpes simplex virus type 1. Antiviral Res. 102:1-10, 2014.
10) Ma Y, He Y, Zhao R, Wu Y, Li W*, Cao Z*. Extreme diversity of scorpion venom peptides and proteins revealed by transcriptomic analysis: Implication for proteome evolution of scorpion venom arsenal. J Proteomics. 75(5):1563-1576, 2012.
11) Zhao R, Ma Y, He Y, Di Z, Wu Y, Cao Z*, Li W*. Comparative venom gland transcriptome analysis of the scorpion Lychas mucronatus reveals intraspecific toxic gene diversity and new venomous components. BMC Genomics. 11: 452, 2010.
12) Ma Y, Zhao Y, Zhao R, Zhang W, He Y, Wu Y, Cao Z*, Guo L*, Li W*. Molecular diversity of toxic components from the scorpion Heterometrus petersii venom revealed by proteomic and transcriptome analysis. Proteomics. 10(13):2471-2485, 2010.
13) Li Z, Xu X, Meng L, Zhang Q, Cao L, Li W, Wu Y, Cao Z*. Hp1404, a new antimicrobial peptide from the scorpion Heterometrus petersii. PLoS One. 9(5):e97539, 2014.
14) Chen Y, Cao L, Zhong M, Zhang Y, Han C, Li Q, Yang J, Zhou D, Shi W, He B, Liu F, Yu J, Sun Y, Cao Y, Li Y, Li W, Guo D, Cao Z*, Yan H*. Anti-HIV-1 activity of a new scorpion venom peptide derivative Kn2-7. PLoS One. 7(4):e34947, 2012.
15) Cao L, Dai C, Li Z, Fan Z, Song Y, Wu Y, Cao Z*, Li W*. Antibacterial activity and mechanism of a scorpion venom Peptide derivative in vitro and in vivo. PLoS One. 7(7):e40135, 2012.
16) Zhao R, Dai H, Qiu S, Li T, He Y, Ma Y, Chen Z, Wu Y, Li W*, Cao Z*. SdPI, the first functionally characterized Kunitz-type trypsin inhibitor from scorpion venom. PLoS One. 6(11):e27548,2011.
17) Cao Z#, Di Z, Wu Y, Li W. Overview of scorpion species from China and their toxins. Toxins (Basel). 6(3):796-815,2014.
18) Cao L, Li Z, Zhang R, Wu Y, Li W, Cao Z*. StCT2, a new antibacterial peptide characterized from the venom of the scorpion Scorpiops tibetanus. Peptides. 36(2):213-220, 2012.
19) Yan R, Zhao Z, He Y, Wu L, Cai D, Hong W, Wu Y, Cao Z*, Zheng C*, Li W*. A new natural α-helical peptide from the venom of the scorpion Heterometrus petersii kills HCV. Peptides. 32: 11-19, 2011.
20) Yuan W, Cao L, Ma Y, Mao P, Wang W, Zhao R, Wu Y, Cao Z*, Li W*. Cloning and functional characterization of a new antimicrobial peptide gene StCT1 from the venom of the scorpion Scorpiops tibetanus. Peptides. 31(1):22-26, 2010.
21) Chen Z, Hu Y, Han S, Yin S, He Y, Wu Y, Cao Z* Li W*. ImKTx1, a new Kv1.3 channel blocker with a unique primary structure. J Biochem Mol Toxicol. 25(4):244-251, 2011.
原始链接：http://www.bio.whu.edu.cn/News_reads.asp?cid=174&id=1535
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