T. Jake Liang NIDDK, National Institutes of Health -HBV人物介绍系列
原帖由brent1121发表于 2010-9-5 15:01T. Jake Liang是位华裔科学家，现在是一个tenured senior investigator以及Liver Diseases Branch的负责人，毕业于哈佛大学医学院，他的主要研究方向是HBV和HCV以及临床肝脏疾病，他以前的研究方向是HBV，他在这方面做出了大量杰出的工作，这个看他发表的文章就可以知道了。
Chung RT, Gale M Jr, Polyak SJ, Lemon SM, Liang TJ, Hoofnagle JH Mechanisms of action of interferon and ribavirin in chronic hepatitis C: Summary of a workshop. Hepatology(47): 306-20, 2008.
Huang Y, Yang H, Borg BB, Su X, Rhodes SL, Yang K, Tong X, Tang G, Howell CD, Rosen HR, Thio CL, Thomas DL, Alter HJ, Sapp RK, Liang TJ A functional SNP of interferon-gamma gene is important for interferon-alpha-induced and spontaneous recovery from hepatitis C virus infection. Proc Natl Acad Sci U S A(104): 985-90, 2007.
Yu X, Qiao M, Atanasov I, Hu Z, Kato T, Liang TJ, Zhou ZH Cryo-electron microscopy and three-dimensional reconstructions of hepatitis C virus particles. Virology(367): 126-34, 2007.
Huang Y, Feld JJ, Sapp RK, Nanda S, Lin JH, Blatt LM, Fried MW, Murthy K, Liang TJ Defective hepatic response to interferon and activation of suppressor of cytokine signaling 3 in chronic hepatitis C. Gastroenterology(132): 733-44, 2007.
Ghany M, Liang TJ Drug targets and molecular mechanisms of drug resistance in chronic hepatitis B. Gastroenterology(132): 1574-85, 2007.
Hussain N, Feld JJ, Kleiner DE, Hoofnagle JH, Garcia-Eulate R, Ahlawat S, Koziel DE, Anderson V, Hilligoss D, Choyke P, Gallin JI, Liang TJ, Malech HL, Holland SM, Heller T Hepatic abnormalities in patients with chronic granulomatous disease. Hepatology(45): 675-83, 2007.
Feld JJ, Nanda S, Huang Y, Chen W, Cam M, Pusek SN, Schweigler LM, Theodore D, Zacks SL, Liang TJ, Fried MW Hepatic gene expression during treatment with peginterferon and ribavirin: Identifying molecular pathways for treatment response. Hepatology(46): 1548-63, 2007.
Elmowalid GA, Qiao M, Jeong SH, Borg BB, Baumert TF, Sapp RK, Hu Z, Murthy K, Liang TJ Immunization with hepatitis C virus-like particles results in control of hepatitis C virus infection in chimpanzees. Proc Natl Acad Sci U S A(104): 8427-32, 2007.
Hoofnagle JH, Doo E, Liang TJ, Fleischer R, Lok AS Management of hepatitis B: summary of a clinical research workshop. Hepatology(45): 1056-75, 2007.
Lutchman G, Danehower S, Song BC, Liang TJ, Hoofnagle JH, Thomson M, Ghany MG Mutation rate of the hepatitis C virus NS5B in patients undergoing treatment with ribavirin monotherapy. Gastroenterology(132): 1757-66, 2007.
Yee LJ, Tang YM, Kleiner DE, Wang D, Im K, Wahed A, Tong X, Rhodes S, Su X, Whelan RM, Fontana RJ, Ghany MG, Borg B, Liang TJ, Yang H
13. Kato T, Matsumura T, Heller T, Saito S, Sapp RK, Murthy K, Wakita T, Liang TJ Production of infectious hepatitis C virus of various genotypes in cell cultures. J Virol(81): 4405-11, 2007.
Liang TJ Shortened therapy for hepatitis C virus genotype 2 or 3--is less more? N Engl J Med(357): 176-8, 2007.
Lutchman G, Modi A, Kleiner DE, Promrat K, Heller T, Ghany M, Borg B, Loomba R, Liang TJ, Premkumar A, Hoofnagle JH The effects of discontinuing pioglitazone in patients with nonalcoholic steatohepatitis. Hepatology(46): 424-9, 2007.
Hu Z, Zhang Z, Kim JW, Huang Y, Liang TJ Altered proteolysis and global gene expression in hepatitis B virus X transgenic mouse liver. J Virol (80): 1405-13, 2006.
Lutchman G, Promrat K, Kleiner DE, Heller T, Ghany MG, Yanovski JA, Liang TJ, Hoofnagle JH Changes in serum adipokine levels during pioglitazone treatment for nonalcoholic steatohepatitis: relationship to histological improvement. Clin Gastroenterol Hepatol(4): 1048-52, 2006.
Feld JJ, Liang TJ Hepatitis C -- identifying patients with progressive liver injury. Hepatology(43): S194-206, 2006.
Barth H, Liang TJ, Baumert TF Hepatitis C virus entry: molecular biology and clinical implications. Hepatology(44): 527-35, 2006.
Loomba R, Liang TJ Novel approaches to new therapies for hepatitis B virus infection. Antivir Ther(11): 1-15, 2006.
Perumalswami P, Kleiner DE, Lutchman G, Heller T, Borg B, Park Y, Liang TJ, Hoofnagle JH, Ghany MG Steatosis and progression of fibrosis in untreated patients with chronic hepatitis C infection. Hepatology(43): 780-7, 2006.
Liang TJ Supporting the NIH before it is too late. Hepatology(44): 1-2, 2006.
Nanda SK, Herion D, Liang TJ The SH3 binding motif of HCV NS5A protein interacts with Bin1 and is important for apoptosis and infectivity. Gastroenterology(130): 794-809, 2006.
Heller T, Saito S, Auerbach J, Williams T, Moreen TR, Jazwinski A, Cruz B, Jeurkar N, Sapp R, Luo G, Liang TJ An in vitro model of hepatitis C virion production. Proc Natl Acad Sci U S A (102): 2579-83, 2005.
Feld JJ, Liang TJ HCV persistence: cure is still a four letter word. Hepatology (41): 23-5, 2005.
Baumert TF, Yang C, Schurmann P, Kock J, Ziegler C, Grullich C, Nassal M, Liang TJ, Blum HE, von Weizsacker F Hepatitis B virus mutations associated with fulminant hepatitis induce apoptosis in primary Tupaia hepatocytes. Hepatology (41): 247-56, 2005.
Kim WH, Hong F, Jaruga B, Zhang ZS, Fan SJ, Liang TJ, Gao B Hepatitis B virus X protein sensitizes primary mouse hepatocytes to ethanol- and TNF-alpha-induced apoptosis by a caspase-3-dependent mechanism. Cell Mol Immunol (2): 40-8, 2005.
Wakita T, Pietschmann T, Kato T, Date T, Miyamoto M, Zhao Z, Murthy K, Habermann A, Krausslich HG, Mizokami M, Bartenschlager R, Liang TJ Production of infectious hepatitis C virus in tissue culture from a cloned viral genome. Nat Med (11): 791-6, 2005.
Cai Z, Zhang C, Chang KS, Jiang J, Ahn BC, Wakita T, Liang TJ, Luo G Robust production of infectious hepatitis C virus (HCV) from stably HCV cDNA-transfected human hepatoma cells. J Virol (79): 13963-73, 2005.
Balasubramanian A, Munshi N, Koziel MJ, Hu Z, Liang TJ, Groopman JE, Ganju RK Structural proteins of Hepatitis C virus induce interleukin 8 production and apoptosis in human endothelial cells. J Gen Virol (86): 3291-301, 2005.
Barth H, Ulsenheimer A, Pape GR, Diepolder HM, Hoffmann M, Neumann-Haefelin C, Thimme R, Henneke P, Klein R, Paranhos-Baccala G, Depla E, Liang TJ, Blum HE, Baumert TF Uptake and presentation of hepatitis C virus-like particles by human dendritic cells. Blood (105): 3605-14, 2005.
Promrat K Lutchman G Uwaifo GI Freedman RJ Soza A Heller T Doo E Ghany M Premkumar A Park Y Liang TJ Yanovski JA Kleiner DE Hoofnagle JH A pilot study of pioglitazone treatment for nonalcoholic steatohepatitis. Hepatology (39): 188-96, 2004.
Rahman F Heller T Sobao Y Mizukoshi E Nascimbeni M Alter H Herrine S Hoofnagle J Liang TJ Rehermann B Effects of antiviral therapy on the cellular immune response in acute hepatitis C. Hepatology (40): 87-97, 2004.
Cai Z Liang TJ Luo G Effects of mutations of the initiation nucleotides on hepatitis C virus RNA replication in the cell. J Virol (78): 3633-43, 2004.
Keck ZY Sung VM Perkins S Rowe J Paul S Liang TJ Lai MM Foung SK Human monoclonal antibody to hepatitis C virus E1 glycoprotein that blocks virus attachment and viral infectivity. J Virol (78): 7257-63, 2004.
Jeong SH Qiao M Nascimbeni M Hu Z Rehermann B Murthy K Liang TJ Immunization with hepatitis C virus-like particles induces humoral and cellular immune responses in nonhuman primates. J Virol (78): 6995-7003, 2004.
Qiao M, Ashok M, Bernard KA, Palacios G, Zhou ZH, Lipkin WI, Liang TJ Induction of sterilizing immunity against West Nile Virus (WNV), by immunization with WNV-like particles produced in insect cells. J Infect Dis (190): 2104-8, 2004.
Zhang Z Protzer U Hu Z Jacob J Liang TJ Inhibition of cellular proteasome activities enhances hepadnavirus replication in an HBX-dependent manner. J Virol (78): 4566-72, 2004.
Steinmann D, Barth H, Gissler B, Schurmann P, Adah MI, Gerlach JT, Pape GR, Depla E, Jacobs D, Maertens G, Patel AH, Inchauspe G, Liang TJ, Blum HE, Baumert TF Inhibition of hepatitis C virus-like particle binding to target cells by antiviral antibodies in acute and chronic hepatitis C. J Virol (78): 9030-40, 2004.
Radaeva S Jaruga B Kim WH Heller T Liang TJ Gao B Interferon-gamma inhibits interferon-alpha signalling in hepatic cells: evidence for the involvement of STAT1 induction and hyperexpression of STAT1 in chronic hepatitis C. Biochem J (379): 199-208, 2004.
Locarnini S, Hatzakis A, Heathcote J, Keeffe EB, Liang TJ, Mutimer D, Pawlotsky JM, Zoulim F Management of antiviral resistance in patients with chronic hepatitis B. Antivir Ther (9): 679-93, 2004.
Liang TJ, Heller T Pathogenesis of hepatitis C-associated hepatocellular carcinoma. Gastroenterology (127): S62-71, 2004.
Promrat K McDermott DH Gonzalez CM Kleiner DE Koziol DE Lessie M Merrell M Soza A Heller T Ghany M Park Y Alter HJ Hoofnagle JH Murphy PM Liang TJ Associations of chemokine system polymorphisms with clinical outcomes and treatment responses of chronic hepatitis C. Gastroenterology (124): 352-60, 2003.
Promrat K Liang TJ Chemokine systems and hepatitis C virus infection: is truth in the genes of the beholders? Hepatology (38): 1359-62, 2003.
Milich D Liang TJ Exploring the biological basis of hepatitis B e antigen in hepatitis B virus infection. Hepatology (38): 1075-86, 2003.
Qiao M Murata K Davis AR Jeong SH Liang TJ Hepatitis C virus-like particles combined with novel adjuvant systems enhance virus-specific immune responses. Hepatology (37): 52-9, 2003.
Murata K Lechmann M Qiao M Gunji T Alter HJ Liang TJ Immunization with hepatitis C virus-like particles protects mice from recombinant hepatitis C virus-vaccinia infection. Proc Natl Acad Sci U S A (100): 6753-8, 2003.
Hoofnagle JH Ghany MG Kleiner DE Doo E Heller T Promrat K Ong J Khokhar F Soza A Herion D Park Y Everhart JE Liang TJ Maintenance therapy with ribavirin in patients with chronic hepatitis C who fail to respond to combination therapy with interferon alfa and ribavirin. Hepatology (38): 66-74, 2003.
Ghany MG Kleiner DE Alter H Doo E Khokar F Promrat K Herion D Park Y Liang TJ Hoofnagle JH Progression of fibrosis in chronic hepatitis C. Gastroenterology (124): 97-104, 2003.
Thomson M Nascimbeni M Havert MB Major M Gonzales S Alter H Feinstone SM Murthy KK Rehermann B Liang TJ The clearance of hepatitis C virus infection in chimpanzees may not necessarily correlate with the appearance of acquired immunity. J Virol (77): 862-70, 2003.
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