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标题: Michael Nassal,Freiburg,德国——HBV相关实验室及人物介绍系列 [打印本页]

作者: bigben446    时间: 2016-5-9 23:56
标题: Michael Nassal,Freiburg,德国——HBV相关实验室及人物介绍系列
本帖最后由 bigben446 于 2016-5-10 00:25 编辑

Michael Nassal,Freiburg,德国——HBV相关实验室及人物介绍系列
研究乙肝复制,位于University Hospital Freiburg,德国

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Nassal, M. and C. Skamel, et al. (2008). "Development of hepatitis B virus capsids into a whole-chain protein antigen display platform: new particulate Lyme disease vaccines." Int J Med Microbiol 298(1-2): 135-42.
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Sun, D. and M. Nassal (2006). "Stable HepG2- and Huh7-based human hepatoma cell lines for efficient regulated expression of infectious hepatitis B virus." J Hepatol 45(5): 636-45.
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Nassal, M. and C. Skamel, et al. (2005). "A fusion product of the complete Borrelia burgdorferi outer surface protein A (OspA) and the hepatitis B virus capsid protein is highly immunogenic and induces protective immunity similar to that seen with an effective lipidated OspA vaccine formula." Eur J Immunol 35(2): 655-65.
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Nassal, M. and K. Dallmeier, et al. (2005). "Phenotyping hepatitis B virus variants: from transfection towards a small animal  in vivo infection model." J Clin Virol 34 Suppl 1: S89-95.
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Jacquard, A. C. and M. Nassal, et al. (2004). "Effect of a combination of clevudine and emtricitabine with adenovirus-mediated delivery of gamma interferon in the woodchuck model of hepatitis B virus infection." Antimicrob Agents Chemother 48(7): 2683-92.
Schultz, U. and E. Grgacic, et al. (2004). "Duck hepatitis B virus: an invaluable model system for HBV infection." Adv Virus Res 63: 1-70.
Kock, J. and M. Nassal, et al. (2004). "Hepatitis B virus nucleocapsids formed by carboxy-terminally mutated core proteins contain spliced viral genomes but lack full-size DNA." J Virol 78(24): 13812-8.
Beck, J. and M. Nassal (2004). "In vitro reconstitution of epsilon-dependent duck hepatitis B virus replication initiation." Methods Mol Med 95: 315-25.
von Weizsacker, F. and J. Kock, et al. (2004). "The tupaia model for the study of hepatitis B virus: direct infection and HBV genome transduction of primary tupaia hepatocytes." Methods Mol Med 96: 153-61.
Beck, J. and M. Nassal (2003). "Efficient Hsp90-independent in vitro activation by Hsc70 and Hsp40 of duck hepatitis B virus reverse transcriptase, an assumed Hsp90 client protein." J Biol Chem 278(38): 36128-38.
Nassal, M. (2002). "Ca2+: the clue to hepatitis B virus X protein function?" Hepatology 36(3): 755-7.
Pumpens, P. and E. Grens, et al. (2002). "Molecular epidemiology and immunology of hepatitis B virus infection - an update." Intervirology 45(4-6): 218-32.
Beck, J. and M. Vogel, et al. (2002). "dNTP versus NTP discrimination by phenylalanine 451 in duck hepatitis B virus P protein indicates a common structure of the dNTP-binding pocket with other reverse transcriptases." Nucleic Acids Res 30(7): 1679-87.
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Chouteau, P. and J. Le Seyec, et al. (2001). "A short N-proximal region in the large envelope protein harbors a determinant that contributes to the species specificity of human hepatitis B virus." J Virol 75(23): 11565-72.
Beck, J. and M. Nassal (2001). "Reconstitution of a functional duck hepatitis B virus replication initiation complex from separate reverse transcriptase domains expressed in Escherichia coli." J Virol 75(16): 7410-9.
Kock, J. and M. Nassal, et al. (2001). "Efficient infection of primary tupaia hepatocytes with purified human and woolly  monkey hepatitis B virus." J Virol 75(11): 5084-9.
Ren, S. and M. Nassal (2001). "Hepatitis B virus (HBV) virion and covalently closed circular DNA formation in primary tupaia hepatocytes and human hepatoma cell lines upon HBV genome transduction with replication-defective adenovirus vectors." J Virol 75(3): 1104-16.
Beterams, G. and M. Nassal (2001). "Significant interference with hepatitis B virus replication by a core-nuclease fusion protein." J Biol Chem 276(12): 8875-83.
Beterams, G. and B. Bottcher, et al. (2000). "Packaging of up to 240 subunits of a 17 kDa nuclease into the interior of recombinant hepatitis B virus capsids." FEBS Lett 481(2): 169-76.
Nassal, M. (1999). "Hepatitis B virus replication: novel roles for virus-host interactions." Intervirology 42(2-3): 100-16.
Protzer, U. and M. Nassal, et al. (1999). "Interferon gene transfer by a hepatitis B virus vector efficiently suppresses wild-type virus infection." Proc Natl Acad Sci U S A 96(19): 10818-23.
Kratz, P. A. and B. Bottcher, et al. (1999). "Native display of complete foreign protein domains on the surface of hepatitis B  virus capsids." Proc Natl Acad Sci U S A 96(5): 1915-20.
Schaaf, S. G. and J. Beck, et al. (1999). "A small 2'-OH- and base-dependent recognition element downstream of the initiation site in the RNA encapsidation signal is essential for hepatitis B virus replication initiation." J Biol Chem 274(53): 37787-94.
Beck, J. and M. Nassal (1998). "Formation of a functional hepatitis B virus replication initiation complex involves a major structural alteration in the RNA template." Mol Cell Biol 18(11): 6265-72.
Ulrich, R. and M. Nassal, et al. (1998). "Core particles of hepatitis B virus as carrier for foreign epitopes." Adv Virus Res 50: 141-82.
Konig, S. and G. Beterams, et al. (1998). "Mapping of homologous interaction sites in the hepatitis B virus core protein." J Virol 72(6): 4997-5005.
Beck, J. and M. Nassal (1997). "Sequence- and structure-specific determinants in the interaction between the RNA  encapsidation signal and reverse transcriptase of avian hepatitis B viruses." J Virol 71(7): 4971-80.
Nassal, M. (1997). "Novel molecular approaches toward therapy of chronic hepatitis B." Arch Virol 142(3): 611-28.
Beck, J. and H. Bartos, et al. (1997). "Experimental confirmation of a hepatitis B virus (HBV) epsilon-like bulge-and-loop structure in avian HBV RNA encapsidation signals." Virology 227(2): 500-4.
Rieger, A. and M. Nassal (1996). "Specific hepatitis B virus minus-strand DNA synthesis requires only the 5' encapsidation signal and the 3'-proximal direct repeat DR1." J Virol 70(1): 585-9.
Beck, J. and M. Nassal (1996). "A sensitive procedure for mapping the boundaries of RNA elements binding in vitro translated proteins defines a minimal hepatitis B virus encapsidation signal." Nucleic Acids Res 24(21): 4364-6.
Nassal, M. and H. Schaller (1996). "Hepatitis B virus replication--an update." J Viral Hepat 3(5): 217-26.
Nassal, M. and A. Rieger (1996). "A bulged region of the hepatitis B virus RNA encapsidation signal contains the replication origin for discontinuous first-strand DNA synthesis." J Virol 70(5): 2764-73.
Nassal, M. (1996). "Hepatitis B virus morphogenesis." Curr Top Microbiol Immunol 214: 297-337.
Beck, J. and M. Nassal (1995). "Efficient hammerhead ribozyme-mediated cleavage of the structured hepatitis B virus encapsidation signal in vitro and in cell extracts, but not in intact cells." Nucleic Acids Res 23(24): 4954-62.
Kenney, J. M. and C. H. von Bonsdorff, et al. (1995). "Evolutionary conservation in the hepatitis B virus core structure: comparison of  human and duck cores." Structure 3(10): 1009-19.
Rieger, A. and M. Nassal (1995). "Distinct requirements for primary sequence in the 5'- and 3'-part of a bulge in the hepatitis B virus RNA encapsidation signal revealed by a combined in vivo selection/in vitro amplification system." Nucleic Acids Res 23(19): 3909-15.
Nassal, M. and H. Schaller (1993). "Hepatitis B virus replication." Trends Microbiol 1(6): 221-8.
Knaus, T. and M. Nassal (1993). "The encapsidation signal on the hepatitis B virus RNA pregenome forms a stem-loop structure that is critical for its function." Nucleic Acids Res 21(17): 3967-75.
Nassal, M. and A. Rieger (1993). "An intramolecular disulfide bridge between Cys-7 and Cys61 determines the structure of the secretory core gene product (e antigen) of hepatitis B virus." J Virol 67(7): 4307-15.
Lamberts, C. and M. Nassal, et al. (1993). "Precore-mediated inhibition of hepatitis B virus progeny DNA synthesis." J Virol 67(7): 3756-62.
Broker, M. and M. Noah, et al. (1993). "Expression of hepatitis B virus core gene products with specific immunoreactivity for e antigen (HBeAg) in Saccharomyces cerevisiae." J Biotechnol 29(3): 243-55.
Bichko, V. and F. Schodel, et al. (1993). "Epitopes recognized by antibodies to denatured core protein of hepatitis B virus." Mol Immunol 30(3): 221-31.
Nassal, M. (1992). "Conserved cysteines of the hepatitis B virus core protein are not required for assembly of replication-competent core particles nor for their envelopment." Virology 190(1): 499-505.
Nassal, M. (1992). "The arginine-rich domain of the hepatitis B virus core protein is required for pregenome encapsidation and productive viral positive-strand DNA synthesis but not for virus assembly." J Virol 66(7): 4107-16.
Nassal, M. and A. Rieger, et al. (1992). "Topological analysis of the hepatitis B virus core particle by cysteine-cysteine  cross-linking." J Mol Biol 225(4): 1013-25.
Birnbaum, F. and M. Nassal (1990). "Hepatitis B virus nucleocapsid assembly: primary structure requirements in the core protein." J Virol 64(7): 3319-30.
Nassal, M. and P. R. Galle, et al. (1989). "Proteaselike sequence in hepatitis B virus core antigen is not required for e antigen generation and may not be part of an aspartic acid-type protease." J Virol 63(6): 2598-604.
Nassal, M. (1988). "Total chemical synthesis of a gene for hepatitis B virus core protein and its functional characterization." Gene 66(2): 279-94.
Nassal, M. and L. Theilmann, et al. (1987). "Rapid procedure for the detection of hepatitis delta virus RNA in sera of HBsAg-positive and anti-delta-positive patients." Arzneimittelforschung 37(6): 748-51.






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