中国病毒学论坛|我们一直在坚持!

标题: ChenDingshinn陈定信,台湾大学——HBV相关实验室及人物介绍 [打印本页]

作者: bigben446    时间: 2016-5-10 03:43
标题: ChenDingshinn陈定信,台湾大学——HBV相关实验室及人物介绍
本帖最后由 bigben446 于 2016-5-10 03:57 编辑

ChenDingshinn,台湾大学——HBV相关实验室及人物介绍系列

陈定信,ChenDingshinn,National Taiwan University College of Medicine
乙肝临床,肝癌,疫苗,台湾研究乙肝常青树,美国科学院院士

Kao, J. H. and P. J. Chen, et al. (2004). "Hepatitis B virus genotypes and spontaneous hepatitis B e antigen seroconversion  in Taiwanese hepatitis B carriers." J Med Virol 72(3): 363-9.
Chen, D. S. (2011). "Fighting against viral hepatitis: lessons from Taiwan." Hepatology 54(2): 381-92.
Wang, J. T. and P. J. Chen, et al. (1998). "Prevalence and infectivity of hepatitis G virus and its strain variant, the GB agent, in volunteer blood donors in Taiwan." Transfusion 38(3): 290-5.
Kao, J. H. and P. J. Chen, et al. (1994). "Mixed infections of hepatitis C virus as a factor in acute exacerbations of chronic type C hepatitis." J Infect Dis 170(5): 1128-33.
Liu, C. H. and B. F. Chen, et al. (2006). "Selective transmission of hepatitis C virus quasi species through a needlestick accident in acute resolving hepatitis." Clin Infect Dis 42(9): 1254-9.
Chen, H. L. and C. N. Lee, et al. (2015). "Efficacy of maternal tenofovir disoproxil fumarate in interrupting mother-to-infant transmission of hepatitis B virus." Hepatology 62(2): 375-86.
Fang, S. H. and B. L. Chiang, et al. (2001). "Functional measurement of hepatitis C virus core-specific CD8(+) T-cell responses in the livers or peripheral blood of patients by using autologous peripheral blood mononuclear cells as targets or stimulators." J Clin Microbiol 39(11): 3895-901.
Chen, H. L. and M. H. Chang, et al. (1996). "Seroepidemiology of hepatitis B virus infection in children: Ten years of mass vaccination in Taiwan." JAMA 276(11): 906-8.
Wang, J. T. and T. H. Wang, et al. (1990). "Hepatitis C virus in a prospective study of posttransfusion non-A, non-B hepatitis in Taiwan." J Med Virol 32(2): 83-6.
Ni, Y. H. and H. Y. Hsu, et al. (1993). "Absence or delayed appearance of hepatitis B core antibody in chronic hepatitis B surface antigen carrier children." J Hepatol 17(2): 150-4.
Su, T. H. and P. J. Chen, et al. (2011). "The clinical significance of occult hepatitis B transfusion in Taiwan--a look-back study." Transfus Med 21(1): 33-41.
Chen, D. S. (2003). "Viral hepatitis: from A to E, and beyond?" J Formos Med Assoc 102(10): 671-9.
Wang, H. W. and H. L. Wu, et al. (1997). "Identification of the functional regions required for hepatitis D virus replication and transcription by linker-scanning mutagenesis of viral genome." Virology 239(1): 119-31.
Chen, C. H. and P. J. Chen, et al. (1994). "Fibrosing cholestatic hepatitis in a hepatitis B surface antigen carrier after renal transplantation." Gastroenterology 107(5): 1514-8.
Liu, C. J. and B. F. Chen, et al. (2006). "Role of hepatitis B viral load and basal core promoter mutation in hepatocellular carcinoma in hepatitis B carriers." J Infect Dis 193(9): 1258-65.
Chen, C. L. and J. Y. Yang, et al. (2015). "Slow decline of hepatitis B burden in general population: Results from a population-based survey and longitudinal follow-up study in Taiwan." J Hepatol 63(2): 354-63.
Liu, C. J. and M. Y. Lai, et al. (2001). "Lamivudine treatment for hepatitis B reactivation in HBsAg carriers after organ transplantation: a 4-year experience." J Gastroenterol Hepatol 16(9): 1001-8.
Wang, J. T. and F. C. Tsai, et al. (1996). "A prospective study of transfusion-transmitted GB virus C infection: similar frequency but different clinical presentation compared with hepatitis C virus." Blood 88(5): 1881-6.
Chen, D. S. and G. C. Kuo, et al. (1990). "Hepatitis C virus infection in an area hyperendemic for hepatitis B and chronic liver disease: the Taiwan experience." J Infect Dis 162(4): 817-22.
Sheu, J. C. and J. T. Wang, et al. (1993). "Prevalence of hepatitis C viral infection in a community in Taiwan. Detection by  synthetic peptide-based assay and polymerase chain reaction." J Hepatol 17(2): 192-8.
Liu, C. H. and C. C. Liang, et al. (2010). "Pegylated interferon alfa-2a monotherapy for hemodialysis patients with acute hepatitis C." Clin Infect Dis 51(5): 541-9.
Fang, C. T. and P. J. Chen, et al. (2003). "Dynamics of plasma hepatitis B virus levels after highly active antiretroviral therapy in patients with HIV infection." J Hepatol 39(6): 1028-35.
Chen, P. J. and H. L. Wu, et al. (1997). "Molecular biology of hepatitis D virus: research and potential for application." J Gastroenterol Hepatol 12(9-10): S188-92.
Wang, H. W. and P. J. Chen, et al. (1994). "Packaging of hepatitis delta virus RNA via the RNA-binding domain of hepatitis delta antigens: different roles for the small and large delta antigens." J Virol 68(10): 6363-71.
Liu, C. J. and M. Y. Lai, et al. (2006). "Interferon alpha-2b with and without ribavirin in the treatment of hepatitis B e  antigen-positive chronic hepatitis B: a randomized study." Hepatology 43(4): 742-9.
Cheng, H. R. and J. H. Kao, et al. (2015). "Clinical significance of circulating miR-122 in patients with dual chronic hepatitis B and C virus infection." Hepatol Int 9(1): 35-42.
Kao, J. H. and P. J. Chen, et al. (2001). "Acute exacerbations of chronic hepatitis B are rarely associated with superinfection of hepatitis B virus." Hepatology 34(4 Pt 1): 817-23.
Hwang, L. H. and P. M. Yang, et al. (1996). "Identification of humoral antigenic determinants in the hepatitis C virus NS3 protein." J Infect Dis 174(1): 173-6.
Lai, M. Y. and P. J. Chen, et al. (1990). "Identification and characterization of intrahepatic hepatitis B virus DNA in HBsAg-seronegative patients with chronic liver disease and hepatocellular carcinoma in Taiwan." Hepatology 12(3 Pt 1): 575-81.
Wang, J. T. and T. H. Wang, et al. (1993). "Hepatitis C virus infection in volunteer blood donors in Taiwan. Evaluation by hepatitis C antibody assays and the polymerase chain reaction." Arch Pathol Lab Med 117(2): 152-6.
Lin, Y. J. and L. R. Huang, et al. (2010). "Hepatitis B virus core antigen determines viral persistence in a C57BL/6 mouse model." Proc Natl Acad Sci U S A 107(20): 9340-5.
Liu, C. J. and P. J. Chen, et al. (2003). "Clinical aspects and outcomes of volunteer blood donors testing positive for hepatitis-C virus infection in Taiwan: a prospective study." Liver Int 23(3): 148-55.
Kao, J. H. and C. J. Liu, et al. (1997). "Interspousal transmission of GB virus-C/hepatitis G virus: a comparison with hepatitis C virus." J Med Virol 53(4): 348-53.
Chen, C. H. and J. C. Sheu, et al. (1994). "Genotypes of hepatitis C virus in chronic liver disease in Taiwan." J Med Virol 44(3): 234-6.
Liu, C. J. and J. M. Liou, et al. (2005). "Natural course and treatment of dual hepatitis B virus and hepatitis C virus infections." J Formos Med Assoc 104(11): 783-91.
Liu, C. H. and C. C. Liang, et al. (2015). "Comparison of Abbott RealTime HCV Genotype II with Versant line probe assay 2.0 for hepatitis C virus genotyping." J Clin Microbiol 53(5): 1754-7.
Kao, J. H. and H. M. Hsu, et al. (2001). "Universal hepatitis B vaccination and the decreased mortality from fulminant hepatitis in infants in Taiwan." J Pediatr 139(3): 349-52.
Kao, J. H. and P. J. Chen, et al. (1996). "Absence of extensive genetic heterogeneity of hepatitis C virus in antibody-negative chronic hepatitis C." J Med Virol 49(2): 87-90.
Chen, P. J. and M. Y. Kuo, et al. (1990). "Continuous expression and replication of the hepatitis delta virus genome in Hep  G2 hepatoblastoma cells transfected with cloned viral DNA." Proc Natl Acad Sci U S A 87(14): 5253-7.
Chen, P. J. and W. J. Lai, et al. (1993). "Hepatitis B surface antigen and large-form hepatitis delta antigen in HDV assembly: a further study." Prog Clin Biol Res 382: 29-34.
Liu, C. H. and C. C. Liang, et al. (2010). "The ratio of aminotransferase to platelets is a useful index for predicting hepatic fibrosis in hemodialysis patients with chronic hepatitis C." Kidney Int 78(1): 103-9.
Lin, H. H. and J. H. Kao, et al. (2003). "Secular trend of age-specific prevalence of hepatitis B surface and e antigenemia in pregnant women in Taiwan." J Med Virol 69(4): 466-70.
Wu, H. L. and P. J. Chen, et al. (1997). "Assembly of hepatitis delta virus-like empty particles in yeast." Virology 236(2): 374-81.
Tsuei, D. J. and P. J. Chen, et al. (1994). "Inverse polymerase chain reaction for cloning cellular sequences adjacent to integrated hepatitis B virus DNA in hepatocellular carcinomas." J Virol Methods 49(3): 269-84.
Liu, C. J. and J. H. Kao, et al. (2005). "Therapeutic implications of hepatitis B virus genotypes." Liver Int 25(6): 1097-107.
Chang, M. H. and D. S. Chen (2015). "Prevention of hepatitis B." Cold Spring Harb Perspect Med 5(3): a021493.
Mu, J. J. and D. S. Chen, et al. (2001). "The conserved serine 177 in the delta antigen of hepatitis delta virus is one putative phosphorylation site and is required for efficient viral RNA replication." J Virol 75(19): 9087-95.
Lin, H. H. and J. H. Kao, et al. (1996). "Serotypes, genotypes and levels of hepatitis C viremia in pregnant women in Taiwan." J Formos Med Assoc 95(6): 429-34.
Lee, P. I. and M. H. Chang, et al. (1990). "Prognostic implications of serum alpha-fetoprotein levels in neonatal hepatitis." J Pediatr Gastroenterol Nutr 11(1): 27-31.
Lin, H. H. and J. H. Kao, et al. (1993). "Comparison of three different immunoassays and PCR for the detection of hepatitis C virus infection in pregnant women in Taiwan." Vox Sang 65(2): 117-21.
Jan, C. F. and K. C. Huang, et al. (2010). "Determination of immune memory to hepatitis B vaccination through early booster response in college students." Hepatology 51(5): 1547-54.
Liu, C. J. and P. J. Chen, et al. (2003). "Ribavirin and interferon is effective for hepatitis C virus clearance in hepatitis B and C dually infected patients." Hepatology 37(3): 568-76.
Kao, J. H. and M. Y. Lai, et al. (1997). "Immunoglobulin M antibody response to hepatitis C virus core protein in patients  with chronic hepatitis C." J Formos Med Assoc 96(10): 825-8.
Chang, M. H. and Y. H. Ni, et al. (1994). "Long term clinical and virologic outcome of primary hepatitis C virus infection in children: a prospective study." Pediatr Infect Dis J 13(9): 769-73.
Wang, C. W. and L. C. Wang, et al. (2005). "Long-term follow-up of Hepatitis B Surface antibody levels in subjects receiving  universal Hepatitis B vaccination in infancy in an area of hyperendemicity: correlation between radioimmunoassay and enzyme immunoassay." Clin Diagn Lab Immunol 12(12): 1442-7.
Song, L. W. and P. G. Liu, et al. (2015). "Quantitative hepatitis B core antibody levels in the natural history of hepatitis B virus infection." Clin Microbiol Infect 21(2): 197-203.
Liu, C. J. and P. J. Chen, et al. (2001). "Hepatitis B virus variants in patients receiving lamivudine treatment with breakthrough hepatitis evaluated by serial viral loads and full-length viral sequences." Hepatology 34(3): 583-9.
Wang, C. J. and S. Y. Sung, et al. (1996). "N-linked glycosylation of hepatitis B surface antigens is involved but not essential in the assembly of hepatitis delta virus." Virology 220(1): 28-36.
Shih, L. N. and J. C. Sheu, et al. (1990). "Detection of hepatitis B viral DNA by polymerase chain reaction in patients with  hepatitis B surface antigen." J Med Virol 30(3): 159-62.
Wang, J. T. and J. C. Sheu, et al. (1992). "Detection of replicative form of hepatitis C virus RNA in peripheral blood mononuclear cells." J Infect Dis 166(5): 1167-9.
Chen, D. S. (2010). "Toward elimination and eradication of hepatitis B." J Gastroenterol Hepatol 25(1): 19-25.
Kao, J. H. and P. J. Chen, et al. (2003). "Basal core promoter mutations of hepatitis B virus increase the risk of hepatocellular carcinoma in hepatitis B carriers." Gastroenterology 124(2): 327-34.
Hsu, H. Y. and M. H. Chang, et al. (1997). "Surface gene mutants of hepatitis B virus in infants who develop acute or chronic infections despite immunoprophylaxis." Hepatology 26(3): 786-91.
Tsai, S. L. and P. J. Chen, et al. (1994). "Immune response to a hepatitis C virus nonstructural protein in chronic hepatitis C virus infection." J Hepatol 21(3): 403-11.
Chang, M. H. and T. H. Chen, et al. (2005). "Prevention of hepatocellular carcinoma by universal vaccination against hepatitis B virus: the effect and problems." Clin Cancer Res 11(21): 7953-7.
Chou, H. H. and W. H. Chien, et al. (2015). "Age-related immune clearance of hepatitis B virus infection requires the establishment of gut microbiota." Proc Natl Acad Sci U S A 112(7): 2175-80.
Tai, C. L. and W. C. Pan, et al. (2001). "Structure-based mutational analysis of the hepatitis C virus NS3 helicase." J Virol 75(17): 8289-97.
Chen, D. S. and H. M. Hsu, et al. (1996). "A program for eradication of hepatitis B from Taiwan by a 10-year, four-dose vaccination program." Cancer Causes Control 7(3): 305-11.
Chen, P. J. and P. M. Yang, et al. (1989). "Characterization of the transcripts of hepatitis D and B viruses in infected human livers." J Infect Dis 160(6): 944-7.
Wang, J. T. and T. H. Wang, et al. (1992). "Posttransfusion hepatitis revisited by hepatitis C antibody assays and polymerase chain reaction." Gastroenterology 103(2): 609-16.
Ni, Y. H. and D. S. Chen (2010). "Hepatitis B vaccination in children: the Taiwan experience." Pathol Biol (Paris) 58(4): 296-300.
Kao, J. H. and W. Chen, et al. (2003). "SEN virus infection in patients with chronic hepatitis C: preferential coinfection with hepatitis C genotype 2a and no effect on response to therapy with interferon plus ribavirin." J Infect Dis 187(2): 307-10.
Chang, M. H. and C. J. Chen, et al. (1997). "Universal hepatitis B vaccination in Taiwan and the incidence of hepatocellular carcinoma in children. Taiwan Childhood Hepatoma Study Group." N Engl J Med 336(26): 1855-9.
Wang, J. T. and T. H. Wang, et al. (1992). "Improved serodiagnosis of posttransfusion hepatitis C virus infection by a second-generation immunoassay based on multiple recombinant antigens." Vox Sang 62(1): 21-4.
Kao, J. H. and S. L. Tsai, et al. (1994). "A clinicopathologic study of chronic non-A, non-B (type C) hepatitis in Taiwan: comparison between posttransfusion and sporadic patients." J Hepatol 21(2): 244-9.
Kao, J. H. and D. S. Chen (2005). "Hepatitis B vaccination: to boost or not to boost?" Lancet 366(9494): 1337-8.
Lin, Y. Y. and C. Liu, et al. (2015). "New insights into the evolutionary rate of hepatitis B virus at different biological scales." J Virol 89(7): 3512-22.
Chen, J. D. and J. L. Chung, et al. (2001). "Post-partum acute exacerbation of chronic hepatitis in a hepatitis C-carrier mother." J Gastroenterol Hepatol 16(6): 705-8.
Kao, J. H. and H. H. Lin, et al. (1996). "Serotyping of hepatitis C virus in chronic type C hepatitis in Taiwan: correlation with genotypes." J Gastroenterol 31(2): 224-7.
Chang, M. H. and D. S. Chen, et al. (1989). "Maternal transmission of hepatitis B virus in childhood hepatocellular carcinoma." Cancer 64(11): 2377-80.
Chen, P. J. and J. T. Wang, et al. (1992). "Transient immunoglobulin M antibody response to hepatitis C virus capsid antigen  in posttransfusion hepatitis C: putative serological marker for acute viral infection." Proc Natl Acad Sci U S A 89(13): 5971-5.
Wang, H. Y. and M. H. Chien, et al. (2010). "Distinct hepatitis B virus dynamics in the immunotolerant and early immunoclearance phases." J Virol 84(7): 3454-63.
Liu, C. J. and P. J. Chen, et al. (2003). "A prospective study characterizing full-length hepatitis B virus genomes during acute exacerbation." Gastroenterology 124(1): 80-90.
Kao, J. H. and W. Chen, et al. (1997). "GB virus-C/hepatitis G virus infection in prostitutes: possible role of sexual transmission." J Med Virol 52(4): 381-4.
Wang, J. T. and T. H. Wang, et al. (1992). "Hepatitis C virus RNA in saliva of patients with posttransfusion hepatitis and low efficiency of transmission among spouses." J Med Virol 36(1): 28-31.
Wang, J. T. and M. T. Lin, et al. (1994). "Transfusion-transmitted human T-cell lymphotropic virus type I infection in Taiwan: a true risk and occasional coinfection with hepatitis C virus shown in a  prospective study." Blood 84(3): 934-40.
Liu, C. J. and S. C. Lo, et al. (2006). "Transmission of occult hepatitis B virus by transfusion to adult and pediatric recipients in Taiwan." J Hepatol 44(1): 39-46.
Liang, C. C. and C. H. Liu, et al. (2015). "Advanced hepatic fibrosis and steatosis are associated with persistent alanine aminotransferase elevation in chronic hepatitis C patients negative for hepatitis C virus RNA during pegylated interferon plus ribavirin therapy." J Infect Dis 211(9): 1429-36.
Kao, J. H. and P. J. Chen, et al. (2000). "Efficacy of consensus interferon in the treatment of chronic hepatitis C." J Gastroenterol Hepatol 15(12): 1418-23.
Kao, J. H. and M. Y. Lai, et al. (1996). "Clinical significance of serum hepatitis C virus titers in patients with chronic  type C hepatitis." Am J Gastroenterol 91(3): 506-10.
Chen, P. J. and C. R. Chen, et al. (1989). "Identification of a doubly spliced viral transcript joining the separated domains for putative protease and reverse transcriptase of hepatitis B virus." J Virol 63(10): 4165-71.
Hsu, H. Y. and M. H. Chang, et al. (1992). "Cellular immune response to HBcAg in mother-to-infant transmission of hepatitis B virus." Hepatology 15(5): 770-6.
Chang, M. H. and S. L. You, et al. (2009). "Decreased incidence of hepatocellular carcinoma in hepatitis B vaccinees: a 20-year follow-up study." J Natl Cancer Inst 101(19): 1348-55.
Lin, Y. C. and M. H. Chang, et al. (2003). "Long-term immunogenicity and efficacy of universal hepatitis B virus vaccination  in Taiwan." J Infect Dis 187(1): 134-8.
Kao, J. H. and P. J. Chen, et al. (1997). "Positive and negative strand of hepatitis C virus RNA sequences in peripheral blood mononuclear cells in patients with chronic hepatitis C: no correlation with viral genotypes 1b, 2a, and 2b." J Med Virol 52(3): 270-4.
Wu, H. L. and P. J. Chen, et al. (1991). "Temporal aspects of major viral transcript expression in Hep G2 cells transfected with cloned hepatitis B virus DNA: with emphasis on the X transcript." Virology 185(2): 644-51.
Kao, J. H. and P. J. Chen, et al. (1994). "Detection of Divergent Hepatitis C Virus Envelope Sequences." J Biomed Sci 1(3): 158-162.
Liu, C. J. and P. J. Chen, et al. (2005). "Serum adiponectin correlates with viral characteristics but not histologic features in patients with chronic hepatitis C." J Hepatol 43(2): 235-42.
Liu, C. J. and T. C. Chen, et al. (2015). "Micro-evolution of the hepatitis B virus genome in hepatitis B e-antigen-positive carriers: comparison of genotypes B and C at various immune stages." J Gastroenterol Hepatol 30(1): 172-7.
Kao, J. H. and N. H. Wu, et al. (2000). "Hepatitis B genotypes and the response to interferon therapy." J Hepatol 33(6): 998-1002.
Ni, Y. H. and M. H. Chang, et al. (1996). "Hepatitis C viral infection in thalassemic children: clinical and molecular studies." Pediatr Res 39(2): 323-8.
Yang, P. M. and J. L. Sung, et al. (1989). "HLA-A, B, C and DR antigens in chronic hepatitis B viral infection." Hepatogastroenterology 36(5): 363-6.
Chen, C. L. and H. I. Yang, et al. (2008). "Metabolic factors and risk of hepatocellular carcinoma by chronic hepatitis B/C infection: a follow-up study in Taiwan." Gastroenterology 135(1): 111-21.
Chen, P. J. and F. L. Chang, et al. (1992). "Functional study of hepatitis delta virus large antigen in packaging and replication inhibition: role of the amino-terminal leucine zipper." J Virol 66(5): 2853-9.
Wang, S. H. and S. H. Yeh, et al. (2009). "Identification of androgen response elements in the enhancer I of hepatitis B virus: a mechanism for sex disparity in chronic hepatitis B." Hepatology 50(5): 1392-402.
Kao, J. H. and P. J. Chen, et al. (2002). "Occult hepatitis B virus infection and clinical outcomes of patients with chronic hepatitis C." J Clin Microbiol 40(11): 4068-71.
Yang, P. M. and J. T. Wang, et al. (1997). "Serum 2',5'-oligoadenylate synthetase concentrations in acute and chronic hepatitis C." J Formos Med Assoc 96(5): 314-9.
Lin, H. H. and H. Y. Hsu, et al. (1991). "Low prevalence of hepatitis C virus and infrequent perinatal or spouse infections in pregnant women in Taiwan." J Med Virol 35(4): 237-40.
Lin, H. H. and H. Y. Hsu, et al. (1994). "Age-specific prevalence of hepatitis B surface and e antigenemia in pregnant women in Taiwan." Asia Oceania J Obstet Gynaecol 20(2): 141-5.
Hsieh, T. H. and J. H. Kao, et al. (2005). "Successful treatment with peginterferon and ribavirin in a patient with acute hepatitis C evolving into chronicity." J Formos Med Assoc 104(5): 354-8.
Hsu, C. S. and S. J. Hsu, et al. (2014). "A pilot study of add-on oral hypoglycemic agents in treatment-naive genotype-1 chronic hepatitis C patients receiving peginterferon alfa-2b plus ribavirin." J Formos Med Assoc 113(10): 716-21.
Chang, M. H. and W. Y. Shau, et al. (2000). "Hepatitis B vaccination and hepatocellular carcinoma rates in boys and girls." JAMA 284(23): 3040-2.
Chen, D. S. (1996). "Viral hepatitis in East Asia." J Formos Med Assoc 95(1): 6-12.
Chang, M. H. and J. L. Sung, et al. (1989). "Factors affecting clearance of hepatitis B e antigen in hepatitis B surface antigen carrier children." J Pediatr 115(3): 385-90.
Lu, C. Y. and Y. H. Ni, et al. (2008). "Humoral and cellular immune responses to a hepatitis B vaccine booster 15-18 years after neonatal immunization." J Infect Dis 197(10): 1419-26.
Chen, P. J. and M. H. Lin, et al. (1992). "The Taiwanese hepatitis C virus genome: sequence determination and mapping the 5' termini of viral genomic and antigenomic RNA." Virology 188(1): 102-13.
Liu, C. J. and P. J. Chen, et al. (2009). "High serum adiponectin correlates with advanced liver disease in patients with chronic hepatitis B virus infection." Hepatol Int 3(2): 364-70.
Liu, C. J. and J. H. Kao, et al. (2002). "Naturally occurring hepatitis B surface gene variants in chronic hepatitis B virus infection: correlation with viral serotypes and clinical stages of liver disease." J Med Virol 68(1): 50-9.
Kao, J. H. and P. J. Chen, et al. (1997). "GB virus-C/hepatitis G virus infection in an area endemic for viral hepatitis, chronic liver disease, and liver cancer." Gastroenterology 112(4): 1265-70.
Wang, C. J. and P. J. Chen, et al. (1991). "Small-form hepatitis B surface antigen is sufficient to help in the assembly of hepatitis delta virus-like particles." J Virol 65(12): 6630-6.
Ni, Y. H. and M. H. Chang, et al. (1994). "Posttransfusion hepatitis C virus infection in children." J Pediatr 124(5 Pt 1): 709-13.
Liu, C. J. and Y. M. Jeng, et al. (2005). "Influence of metabolic syndrome, viral genotype and antiviral therapy on superimposed fatty liver disease in chronic hepatitis C." Antivir Ther 10(3): 405-15.
Huang, Y. W. and S. S. Yang, et al. (2014). "Increased risk of cirrhosis and its decompensation in chronic hepatitis C patients with new-onset diabetes: a nationwide cohort study." Hepatology 60(3): 807-14.
Fang, S. H. and L. H. Hwang, et al. (2000). "Ribavirin enhancement of hepatitis C virus core antigen-specific type 1 T helper  cell response correlates with the increased IL-12 level." J Hepatol 33(5): 791-8.
Kao, J. H. and M. Y. Lai, et al. (1996). "Chronic hepatitis C without anti-hepatitis C antibodies by second-generation assay. A clinicopathologic study and demonstration of the usefulness of a third-generation assay." Dig Dis Sci 41(1): 161-5.
Lin, H. H. and P. J. Chen, et al. (1989). "Postpartum subsidence of hepatitis B viral replication in HBeAg-positive carrier  mothers." J Med Virol 29(1): 1-6.
Liu, C. H. and S. J. Hsu, et al. (2007). "Noninvasive diagnosis of hepatic fibrosis in patients with chronic hepatitis C by splenic Doppler impedance index." Clin Gastroenterol Hepatol 5(10): 1199-1206.e1.
Hsu, H. Y. and M. H. Chang, et al. (1992). "Spontaneous loss of HBsAg in children with chronic hepatitis B virus infection." Hepatology 15(3): 382-6.
Liu, C. J. and P. J. Chen, et al. (2009). "Dual chronic hepatitis B virus and hepatitis C virus infection." Hepatol Int 3(4): 517-25.
Kao, J. H. and P. J. Chen, et al. (2002). "Sequence analysis of pre-S/surface and pre-core/core promoter genes of hepatitis  B virus in chronic hepatitis C patients with occult HBV infection." J Med Virol 68(2): 216-20.
Tai, C. L. and W. K. Chi, et al. (1996). "The helicase activity associated with hepatitis C virus nonstructural protein 3 (NS3)." J Virol 70(12): 8477-84.
Chang, F. L. and P. J. Chen, et al. (1991). "The large form of hepatitis delta antigen is crucial for assembly of hepatitis delta virus." Proc Natl Acad Sci U S A 88(19): 8490-4.
Ni, Y. H. and H. H. Lin, et al. (1994). "Temporal profile of hepatitis C virus antibody and genome in infants born to mothers infected with hepatitis C virus but without human immunodeficiency virus  coinfection." J Hepatol 20(5): 641-5.
Mah, Y. H. and J. H. Kao, et al. (2005). "Prevalence and clinical implications of HFE gene mutations (C282Y and H63D) in patients with chronic hepatitis B and C in Taiwan." Liver Int 25(2): 214-9.
Chen, C. L. and W. S. Yang, et al. (2014). "Plasma adipokines and risk of hepatocellular carcinoma in chronic hepatitis B virus-infected carriers: a prospective study in taiwan." Cancer Epidemiol Biomarkers Prev 23(8): 1659-71.
Kao, J. H. and D. S. Chen (2000). "Transmission of hepatitis C virus in Asia: past and present perspectives." J Gastroenterol Hepatol 15 Suppl: E91-6.
Lin, H. H. and J. H. Kao, et al. (1995). "Prevalence, genotypes and antibody titer of hepatitis C virus in pregnant women in Taiwan." J Obstet Gynaecol (Tokyo 1995) 21(6): 557-62.
Huang, L. M. and M. H. Chang, et al. (1989). "Changing aetiologic patterns of acute viral hepatitis in Taiwanese children." J Gastroenterol Hepatol 4(4): 339-44.
Liu, C. H. and C. C. Liang, et al. (2008). "Pegylated interferon alpha-2a versus standard interferon alpha-2a for treatment-naive dialysis patients with chronic hepatitis C: a randomised study." Gut 57(4): 525-30.
Wang, J. T. and T. H. Wang, et al. (1992). "Effects of anticoagulants and storage of blood samples on efficacy of the polymerase chain reaction assay for hepatitis C virus." J Clin Microbiol 30(3): 750-3.
Chen, C. S. and C. T. Chiou, et al. (2009). "Structure-based discovery of triphenylmethane derivatives as inhibitors of hepatitis C virus helicase." J Med Chem 52(9): 2716-23.
Yeh, S. H. and C. F. Chang, et al. (2002). "Dominance of functional androgen receptor allele with longer CAG repeat in hepatitis B virus-related female hepatocarcinogenesis." Cancer Res 62(15): 4346-51.
Kao, J. H. and P. J. Chen, et al. (1997). "Amplification of GB virus-C/hepatitis G virus RNA with primers from different regions of the viral genome." J Med Virol 51(4): 284-9.
Hsu, S. C. and M. H. Chang, et al. (1991). "Non-A, non-B hepatitis in children: a clinical, histologic, and serologic study." J Med Virol 35(1): 1-6.
Tsai, S. L. and P. J. Chen, et al. (1994). "Characterization of T Cell Clones Specific to a Determinant of Hepatitis B Virus  Core and e Antigens in Chronic Type B Hepatitis: Implication for a T Cell Mechanism of HBV Immunopathogenesis." J Biomed Sci 1(2): 105-118.
Wu, H. L. and L. R. Huang, et al. (2005). "RNA interference-mediated control of hepatitis B virus and emergence of resistant mutant." Gastroenterology 128(3): 708-16.
Tseng, T. C. and C. J. Liu, et al. (2015). "Higher proportion of viral basal core promoter mutant increases the risk of liver cirrhosis in hepatitis B carriers." Gut 64(2): 292-302.
Chen, D. S. (2000). "Public health measures to control hepatitis B virus infection in the developing countries of the Asia-Pacific region." J Gastroenterol Hepatol 15 Suppl: E7-10.
Chang, M. H. and H. Y. Hsu, et al. (1995). "The significance of spontaneous hepatitis B e antigen seroconversion in childhood: with special emphasis on the clearance of hepatitis B e antigen before 3 years of age." Hepatology 22(5): 1387-92.
Lee, H. S. and P. M. Yang, et al. (1989). "Pleural effusion coinciding with acute exacerbations in a patient with chronic hepatitis B." Gastroenterology 96(6): 1604-6.
Tseng, T. C. and C. J. Liu, et al. (2007). "Subgenotypes of hepatitis B virus genotype C do not correlate with disease progression of chronic hepatitis B in Taiwan." Liver Int 27(7): 983-8.
Tsai, S. L. and P. J. Chen, et al. (1992). "Acute exacerbations of chronic type B hepatitis are accompanied by increased T cell responses to hepatitis B core and e antigens. Implications for hepatitis B e antigen seroconversion." J Clin Invest 89(1): 87-96.
Chen, D. S. (2009). "Hepatitis B vaccination: The key towards elimination and eradication of hepatitis B." J Hepatol 50(4): 805-16.
Kao, J. H. and P. J. Chen, et al. (2002). "Hepatitis D virus genotypes in intravenous drug users in taiwan: decreasing prevalence and lack of correlation with hepatitis B virus genotypes." J Clin Microbiol 40(8): 3047-9.
Chia, J. S. and H. L. Wu, et al. (1997). "Inhibition of Hepatitis Delta Virus Genomic Ribozyme Self-Cleavage by Aminoglycosides." J Biomed Sci 4(5): 208-216.
Chen, D. S. and J. T. Wang, et al. (1991). "Hepatitis C virus infection in Taiwan." Gastroenterol Jpn 26 Suppl 3: 164-6.
Lin, H. H. and J. H. Kao, et al. (1994). "Possible role of high-titer maternal viremia in perinatal transmission of hepatitis C virus." J Infect Dis 169(3): 638-41.
Yu, M. W. and S. H. Yeh, et al. (2005). "Hepatitis B virus genotype and DNA level and hepatocellular carcinoma: a prospective study in men." J Natl Cancer Inst 97(4): 265-72.
Liu, C. H. and C. J. Liu, et al. (2015). "Peginterferon alfa-2a with or without low-dose ribavirin for treatment-naive patients with hepatitis C virus genotype 2 receiving haemodialysis: a randomised  trial." Gut 64(2): 303-11.
Wang, J. T. and C. Z. Lee, et al. (2000). "Incidence and clinical presentation of posttransfusion TT virus infection in prospectively followed transfusion recipients: emphasis on its relevance to hepatitis." Transfusion 40(5): 596-601.
Kao, J. H. and P. J. Chen, et al. (1995). "Genotypes of hepatitis C virus in Taiwan and the progression of liver disease." J Clin Gastroenterol 21(3): 233-7.
Hsu, H. C. and I. J. Su, et al. (1987). "Biologic and prognostic significance of hepatocyte hepatitis B core antigen expressions in the natural course of chronic hepatitis B virus infection." J Hepatol 5(1): 45-50.
Liu, W. L. and W. C. Su, et al. (2007). "Ribavirin up-regulates the activity of double-stranded RNA-activated protein kinase and enhances the action of interferon-alpha against hepatitis C virus." J Infect Dis 196(3): 425-34.
Yang, W. J. and C. J. Chang, et al. (2009). "Hepatitis B virus X protein enhances the transcriptional activity of the androgen receptor through c-Src and glycogen synthase kinase-3beta kinase pathways." Hepatology 49(5): 1515-24.
Kao, J. H. and D. S. Chen (2002). "Global control of hepatitis B virus infection." Lancet Infect Dis 2(7): 395-403.
Kao, J. H. and M. Y. Lai, et al. (1996). "Serum hepatitis C virus titers in the progression of type C chronic liver disease. With special emphasis on patients with type 1b infection." J Clin Gastroenterol 23(4): 280-3.
Wang, J. T. and T. H. Wang, et al. (1991). "Recombinant immunoblot assay for hepatitis C antibody in patients with posttransfusion non-A, non-B hepatitis." J Med Virol 34(3): 172-5.
Lin, H. H. and H. Y. Hsu, et al. (1994). "Hepatitis C virus infection in pregnant women: detection by different anti-HCV immunoassays and serum HCV-RNA." Asia Oceania J Obstet Gynaecol 20(1): 13-8.
Liu, C. J. and P. J. Chen, et al. (2004). "Lack of interferon sensitivity-determining region in the genome of hepatitis B virus genotype Ba." Antivir Ther 9(6): 895-903.
Wu, H. L. and J. H. Kao, et al. (2014). "Serum cytokine/chemokine profiles in acute exacerbation of chronic hepatitis B: clinical and mechanistic implications." J Gastroenterol Hepatol 29(8): 1629-36.
Kao, J. H. and C. J. Liu, et al. (2000). "Low incidence of hepatitis C virus transmission between spouses: a prospective study." J Gastroenterol Hepatol 15(4): 391-5.
Lee, W. T. and M. H. Chang, et al. (1995). "Immunogenicity of an inactivated hepatitis A vaccine in healthy children: two years' follow-up." Zhonghua Min Guo Xiao Er Ke Yi Xue Hui Za Zhi 36(5): 331-5.
Chen, P. J. and D. S. Chen, et al. (1988). "Delta infection in asymptomatic carriers of hepatitis B surface antigen: low prevalence of delta activity and effective suppression of hepatitis B virus replication." Hepatology 8(5): 1121-4.
Ni, Y. H. and M. H. Chang, et al. (2007). "Viremia profiles in children with chronic hepatitis B virus infection and spontaneous e antigen seroconversion." Gastroenterology 132(7): 2340-5.
Liu, C. J. and Y. M. Jeng, et al. (2009). "Hepatitis B virus basal core promoter mutation and DNA load correlate with expression of hepatitis B core antigen in patients with chronic hepatitis B." J Infect Dis 199(5): 742-9.
Yang, W. T. and L. W. Wu, et al. (2016). "Hepatitis B Surface Antigen Loss and Hepatocellular Carcinoma Development in Patients With Dual Hepatitis B and C Infection." Medicine (Baltimore) 95(10): e2995.
Yang, H. I. and S. N. Lu, et al. (2002). "Hepatitis B e antigen and the risk of hepatocellular carcinoma." N Engl J Med 347(3): 168-74.
Kao, J. H. and M. Wood, et al. (1999). "Comparison of two methods for quantification of hepatitis B viral DNA." J Gastroenterol Hepatol 14(5): 423-6.
Wang, T. H. and J. T. Wang, et al. (1991). "A prospective study of posttransfusion hepatitis in Taiwan." J Hepatol 13(1): 38-43.
Lee, C. Z. and P. J. Chen, et al. (1994). "Isoprenylation of large hepatitis delta antigen is necessary but not sufficient for hepatitis delta virus assembly." Virology 199(1): 169-75.
Ni, Y. H. and M. H. Chang, et al. (2004). "Clinical relevance of hepatitis B virus genotype in children with chronic infection and hepatocellular carcinoma." Gastroenterology 127(6): 1733-8.
Chen, D. S. and S. Locarnini, et al. (2013). "Report from a Viral Hepatitis Policy Forum on implementing the WHO Framework for  Global Action on viral hepatitis in North Asia." J Hepatol 59(5): 1073-80.
Kao, J. H. and P. J. Chen, et al. (2000). "Hepatitis B genotypes correlate with clinical outcomes in patients with chronic hepatitis B." Gastroenterology 118(3): 554-9.
Lee, C. Z. and P. J. Chen, et al. (1995). "Large hepatitis delta antigen in packaging and replication inhibition: role of the carboxyl-terminal 19 amino acids and amino-terminal sequences." J Virol 69(9): 5332-6.
Yang, P. M. and I. J. Su, et al. (1988). "Immunohistochemical studies on intrahepatic lymphocyte infiltrates in chronic type B hepatitis, with special emphasis on the activation status of the lymphocytes." Am J Gastroenterol 83(9): 948-53.
Lin, C. L. and L. Y. Liao, et al. (2007). "Hepatitis B viral factors in HBeAg-negative carriers with persistently normal serum alanine aminotransferase levels." Hepatology 45(5): 1193-8.
Liu, C. J. and W. L. Chuang, et al. (2009). "Peginterferon alfa-2a plus ribavirin for the treatment of dual chronic infection  with hepatitis B and C viruses." Gastroenterology 136(2): 496-504.e3.
Locarnini, S. and D. S. Chen, et al. (2016). "No more excuses: viral hepatitis can be eliminated." Lancet 387(10029): 1703-4.
Pan, C. H. and P. M. Yang, et al. (2002). "T-cell antigenic determinants within hepatitis C virus nonstructural protein 3 and cytokine production profiles in hepatitis C." J Viral Hepat 9(4): 258-64.
Shih, H. H. and M. H. Chang, et al. (1999). "Long term immune response of universal hepatitis B vaccination in infancy: a community-based study in Taiwan." Pediatr Infect Dis J 18(5): 427-32.
Chen, P. J. and M. H. Lin, et al. (1991). "Isolation of a complementary DNA fragment of hepatitis C virus in Taiwan revealed significant sequence variations compared with other isolates." Hepatology 14(1): 73-8.
Ko, T. M. and L. H. Tseng, et al. (1994). "Amniocentesis in mothers who are hepatitis B virus carriers does not expose the infant to an increased risk of hepatitis B virus infection." Arch Gynecol Obstet 255(1): 25-30.
Liu, C. J. and W. L. Huang, et al. (2004). "End-of-treatment virologic response does not predict relapse after lamivudine treatment for chronic hepatitis B." World J Gastroenterol 10(24): 3574-8.
Cheng, H. R. and J. H. Kao, et al. (2014). "Clinical and virological features of occult hepatitis B in patients with HBsAg seroclearance post-treatment or spontaneously." Liver Int 34(6): e71-9.
Kao, J. H. and J. Heptonstall, et al. (1999). "Molecular methods of measurement of hepatitis B virus, hepatitis C virus, and human immunodeficiency virus infection: implications for occupational health practice." Occup Environ Med 56(11): 730-4.
Yang, P. M. and L. H. Hwang, et al. (1995). "Prominent proliferative response of peripheral blood mononuclear cells to a recombinant non-structural (NS3) protein of hepatitis C virus in patients with chronic hepatitis C." Clin Exp Immunol 101(2): 272-7.
Hsu, H. C. and T. T. Wu, et al. (1988). "Evolution of expression of hepatitis B surface and core antigens (HBsAg, HBcAg) in resected primary and recurrent hepatocellular carcinoma in HBsAg carriers in Taiwan. Correlation with local host immune response." Cancer 62(5): 915-21.
Ni, Y. H. and L. M. Huang, et al. (2007). "Two decades of universal hepatitis B vaccination in taiwan: impact and implication for future strategies." Gastroenterology 132(4): 1287-93.
Kao, J. H. and D. S. Chen (2008). "Universal hepatitis B vaccination: killing 2 birds with 1 stone." Am J Med 121(12): 1029-31.
Yuen, M. F. and S. H. Ahn, et al. (2016). "Chronic Hepatitis B Virus Infection: Disease Revisit and Management Recommendations." J Clin Gastroenterol 50(4): 286-94.
Chen, C. W. and Y. G. Tsay, et al. (2002). "The double-stranded RNA-activated kinase, PKR, can phosphorylate hepatitis D virus small delta antigen at functional serine and threonine residues." J Biol Chem 277(36): 33058-67.
Liu, C. J. and J. H. Kao, et al. (1999). "Minimal role of GB virus-C/hepatitis G virus in fulminant and subfulminant hepatitis in Taiwan." J Gastroenterol Hepatol 14(4): 352-7.
Tsen, Y. J. and M. H. Chang, et al. (1991). "Seroprevalence of hepatitis B virus infection in children in Taipei, 1989: five years after a mass hepatitis B vaccination program." J Med Virol 34(2): 96-9.
Hsu, H. Y. and M. H. Chang, et al. (1993). "Association of HLA-DR14-DR52 with low responsiveness to hepatitis B vaccine in Chinese residents in Taiwan." Vaccine 11(14): 1437-40.
Yeh, S. H. and C. Y. Tsai, et al. (2004). "Quantification and genotyping of hepatitis B virus in a single reaction by real-time PCR and melting curve analysis." J Hepatol 41(4): 659-66.
Su, T. H. and C. H. Liu, et al. (2013). "Serum microRNA-122 level correlates with virologic responses to pegylated interferon therapy in chronic hepatitis C." Proc Natl Acad Sci U S A 110(19): 7844-9.
Kao, J. H. and W. Chen, et al. (2000). "TT virus infection in patients with chronic hepatitis B or C: influence on clinical, histological and virological features." J Med Virol 60(4): 387-92.
Wang, J. T. and T. H. Wang, et al. (1995). "Effect of hepatitis C antibody screening in blood donors on post-transfusion hepatitis in Taiwan." J Gastroenterol Hepatol 10(4): 454-8.
Lai, M. Y. and D. S. Chen, et al. (1988). "Status of hepatitis B virus DNA in hepatocellular carcinoma: a study based on paired tumor and nontumor liver tissues." J Med Virol 25(3): 249-58.
Chiu, C. M. and S. H. Yeh, et al. (2007). "Hepatitis B virus X protein enhances androgen receptor-responsive gene expression depending on androgen level." Proc Natl Acad Sci U S A 104(8): 2571-8.
Liu, C. J. and Y. J. Huang, et al. (2009). "Characterization of interleukin 8 in woodchucks with chronic hepatitis B and hepatocellular carcinoma." Genes Immun 10(1): 27-36.
Su, T. H. and C. J. Liu, et al. (2016). "Hepatitis C viral infection increases the risk of lymphoid-neoplasms: A population-based cohort study." Hepatology 63(3): 721-30.
Lee, C. Z. and G. T. Huang, et al. (2002). "Correlation of HBV DNA levels in serum and liver of chronic hepatitis B patients  with cirrhosis." Liver 22(2): 130-5.
Lu, M. Y. and M. H. Chang, et al. (1999). "Hepatitis A vaccine in healthy adults: a comparison of immunogenicity and reactogenicity between two- and three-dose regimens." Vaccine 17(1): 26-30.
Lin, H. H. and M. H. Chang, et al. (1991). "Early predictor of the efficacy of immunoprophylaxis against perinatal hepatitis  B transmission: analysis of prophylaxis failure." Vaccine 9(6): 457-60.
Tai, F. P. and P. J. Chen, et al. (1993). "Hepatitis delta virus cDNA monomer can be used in transfection experiments to initiate viral RNA replication." Virology 197(1): 137-42.
Liu, C. J. and J. H. Kao, et al. (2004). "Origin of serum hepatitis B virus in acute exacerbation: comparison with HBV in the liver and from other exacerbation." Hepatology 40(2): 310-17.
Hsu, C. S. and S. J. Hsu, et al. (2013). "Association of IL28B genotypes with metabolic profiles and viral clearance rate in chronic hepatitis C patients." Hepatol Int 7(1): 171-9.
Chang, M. H. and D. S. Chen (1999). "Prospects for hepatitis B virus eradication and control of hepatocellular carcinoma." Baillieres Best Pract Res Clin Gastroenterol 13(4): 511-7.
Kao, J. H. and P. J. Chen, et al. (1995). "Quasispecies of hepatitis C virus and genetic drift of the hypervariable region in chronic type C hepatitis." J Infect Dis 172(1): 261-4.
Hsu, H. Y. and M. H. Chang, et al. (1988). "Hepatitis D virus infection in children with acute or chronic hepatitis B virus infection in Taiwan." J Pediatr 112(6): 888-92.
Huang, L. R. and H. L. Wu, et al. (2006). "An immunocompetent mouse model for the tolerance of human chronic hepatitis B virus infection." Proc Natl Acad Sci U S A 103(47): 17862-7.
Liu, C. H. and C. J. Liu, et al. (2008). "Pegylated interferon-alpha-2a plus ribavirin for treatment-naive Asian patients with hepatitis C virus genotype 1 infection: a multicenter, randomized controlled trial." Clin Infect Dis 47(10): 1260-9.
Chen, D. S. and Y. F. Liaw, et al. (2015). "Differences in hepatitis viral etiology of hepatocellular carcinoma in Taiwan and China." Hepatology.
Kao, J. H. and P. J. Chen, et al. (2002). "Genotypes and clinical phenotypes of hepatitis B virus in patients with chronic hepatitis B virus infection." J Clin Microbiol 40(4): 1207-9.
Ou-Yang, P. and B. L. Chiang, et al. (1999). "Characterization of monoclonal antibodies against hepatitis C virus nonstructural protein 3: different antigenic determinants from human B cells." J Med Virol 57(4): 345-50.
Wang, J. T. and J. C. Sheu, et al. (1991). "Minimal role of hepatitis B virus in posttransfusion non-A, non-B hepatitis in Taiwan: a study by polymerase chain reaction." J Formos Med Assoc 90(5): 471-5.
Chen, D. S. (1993). "From hepatitis to hepatoma: lessons from type B viral hepatitis." Science 262(5132): 369-70.
Liu, C. J. and P. J. Chen, et al. (2004). "Evolution of precore/core promoter mutations in hepatitis B carriers with hepatitis B e antigen seroreversion." J Med Virol 74(2): 237-45.
Yang, H. C. and C. L. Chen, et al. (2013). "Distinct evolution and predictive value of hepatitis B virus precore and basal core promoter mutations in interferon-induced hepatitis B e antigen seroconversion." Hepatology 57(3): 934-43.
Kao, J. H. and W. Chen, et al. (1999). "Liver and peripheral blood mononuclear cells are not major sites for GB virus-C/hepatitis G virus replication." Arch Virol 144(11): 2173-83.
Chen, C. H. and J. T. Wang, et al. (1995). "Quantitative detection of hepatitis B virus DNA in human sera by branched-DNA signal amplification." J Virol Methods 53(1): 131-7.
Hsu, H. C. and Y. H. Lin, et al. (1988). "Pathology of chronic hepatitis B virus infection in children: with special reference to the intrahepatic expression of hepatitis B virus antigens." Hepatology 8(2): 378-82.
Liu, C. H. and J. W. Lin, et al. (2006). "Noninvasive tests for the prediction of significant hepatic fibrosis in hepatitis C virus carriers with persistently normal alanine aminotransferases." Liver Int 26(9): 1087-94.
Yang, H. I. and S. H. Yeh, et al. (2008). "Associations between hepatitis B virus genotype and mutants and the risk of hepatocellular carcinoma." J Natl Cancer Inst 100(16): 1134-43.
Sarin, S. K. and M. Kumar, et al. (2016). "Asian-Pacific clinical practice guidelines on the management of hepatitis B: a 2015 update." Hepatol Int 10(1): 1-98.
Liu, C. J. and J. H. Kao, et al. (2002). "Molecular epidemiology of hepatitis B viral serotypes and genotypes in taiwan." J Biomed Sci 9(2): 166-70.
Hsu, C. C. and L. H. Hwang, et al. (1998). "An ELISA for RNA helicase activity: application as an assay of the NS3 helicase of hepatitis C virus." Biochem Biophys Res Commun 253(3): 594-9.
Lin, H. H. and R. P. Hsieh, et al. (1991). "Prevalence of antibody to hepatitis C virus in pregnant Taiwanese." J Formos Med Assoc 90(5): 476-9.
Chen, D. S. (1993). "Natural history of chronic hepatitis B virus infection: new light on an old story." J Gastroenterol Hepatol 8(5): 470-5.
Kuang, W. F. and Y. C. Lin, et al. (2004). "Hepatitis C virus NS3 RNA helicase activity is modulated by the two domains of NS3 and NS4A." Biochem Biophys Res Commun 317(1): 211-7.
Liu, W. L. and H. C. Yang, et al. (2012). "Ribavirin enhances the action of interferon-alpha against hepatitis C virus by promoting the p53 activity through the ERK1/2 pathway." PLoS One 7(9): e43824.
Mu, J. J. and H. L. Wu, et al. (1999). "Characterization of the phosphorylated forms and the phosphorylated residues of hepatitis delta virus delta antigens." J Virol 73(12): 10540-5.
Hsu, H. Y. and M. H. Chang, et al. (1995). "Precore mutant of hepatitis B virus in childhood fulminant hepatitis B: an infrequent association." J Infect Dis 171(4): 776-81.
Chen, J. Y. and H. C. Hsu, et al. (1988). "Detection of hepatitis B virus DNA in hepatocellular carcinoma: methylation of integrated viral DNA." J Virol Methods 19(3-4): 257-63.
Liu, C. J. and P. J. Chen, et al. (2006). "Viral factors correlate with hepatitis B e antigen seroconverson in patients with chronic hepatitis B." Liver Int 26(8): 949-55.
Shih, Y. H. and S. H. Yeh, et al. (2008). "Hepatitis B virus quantification and detection of YMDD mutants in a single reaction by real-time PCR and annealing curve analysis." Antivir Ther 13(4): 469-80.
Liu, C. H. and C. F. Huang, et al. (2015). "Peginterferon alfa-2a plus Weight-Based or Flat-Dose Ribavirin for Treatment-Naive Hepatitis C Virus Genotype 2 Rapid Responders: A Randomized Trial." Sci Rep 5: 15255.
Kao, J. H. and M. Y. Lai, et al. (2001). "Probable reinfection with hepatitis C virus in a chronic hepatitis C patient with a sustained response to combination therapy." J Formos Med Assoc 100(12): 824-8.
Kao, J. H. and M. Y. Lai, et al. (1998). "Efficacy of ribavirin plus interferon alpha on viraemia of GB virus-C/hepatitis G virus: comparison with interferon alpha alone." J Gastroenterol Hepatol 13(12): 1249-53.
Wu, H. L. and P. J. Chen, et al. (1991). "Characterization and genetic analysis of alternatively spliced transcripts of hepatitis B virus in infected human liver tissues and transfected HepG2 cells." J Virol 65(4): 1680-6.
Kao, J. H. and P. J. Chen, et al. (1993). "Superinfection of heterologous hepatitis C virus in a patient with chronic type C hepatitis." Gastroenterology 105(2): 583-7.
Chen, C. H. and Y. Y. Chen, et al. (2004). "Hepatitis B virus transmission and hepatocarcinogenesis: a 9 year retrospective cohort of 13676 relatives with hepatocellular carcinoma." J Hepatol 40(4): 653-9.
Lin, Y. J. and H. L. Wu, et al. (2012). "Hepatitis B virus nucleocapsid but not free core antigen controls viral clearance in mice." J Virol 86(17): 9266-73.
Chen, P. J. and D. S. Chen (1999). "Hepatitis B virus infection and hepatocellular carcinoma: molecular genetics and  clinical perspectives." Semin Liver Dis 19(3): 253-62.
Hou, C. H. and W. Y. Chen, et al. (1995). "Intrafamilial transmission of hepatitis C virus in hemodialysis patients." J Med Virol 45(4): 381-5.
Lai, M. Y. and D. S. Chen, et al. (1988). "Reactivation of hepatitis B virus in anti-HBe-positive chronic active type B hepatitis: molecular and immunohistochemical studies." Hepatogastroenterology 35(1): 17-21.
Tsai, F. C. and S. C. Hsieh, et al. (2006). "Reactivation of hepatitis B virus in rheumatologic patients receiving immunosuppressive agents." Dig Dis Sci 51(9): 1627-32.
Wallace, J. and M. Pitts, et al. (2016). "Essential components in developing public policy to control viral hepatitis: lessons from Taiwan." Hepatol Int 10(2): 355-62.
Ou-Yang, P. and L. H. Hwang, et al. (2002). "Co-delivery of GM-CSF gene enhances the immune responses of hepatitis C viral core protein-expressing DNA vaccine: role of dendritic cells." J Med Virol 66(3): 320-8.
Huang, C. H. and J. H. Kao, et al. (1998). "GB virus C/hepatitis G virus infection in patients on continuous ambulatory peritoneal dialysis." Nephrol Dial Transplant 13(11): 2914-9.
Wang, J. T. and T. H. Wang, et al. (1991). "Detection of hepatitis B virus DNA by polymerase chain reaction in plasma of volunteer blood donors negative for hepatitis B surface antigen." J Infect Dis 163(2): 397-9.
Chang, M. H. and C. Y. Lee, et al. (1993). "Minimal role of hepatitis C virus infection in childhood liver diseases in an area hyperendemic for hepatitis B infection." J Med Virol 40(4): 322-5.
Liu, C. J. and P. J. Chen, et al. (2013). "Hepatitis B virus reactivation in patients receiving cancer chemotherapy: natural history, pathogenesis, and management." Hepatol Int 7(2): 316-26.
Chen, J. D. and C. J. Liu, et al. (2004). "Hepatitis B genotypes correlate with tumor recurrence after curative resection of hepatocellular carcinoma." Clin Gastroenterol Hepatol 2(1): 64-71.
Kao, J. H. and C. J. Liu, et al. (2012). "Fine mapping of hepatitis B virus pre-S deletion and its association with hepatocellular carcinoma." Liver Int 32(9): 1373-81.
Chiang, B. L. and P. M. Yang, et al. (1998). "Establishment and characterization of NS3 protein-specific T-cell clones from a patient with chronic hepatitis C." J Biomed Sci 5(4): 290-6.
Lin, H. H. and J. H. Kao, et al. (1995). "Absence of infection in breast-fed infants born to hepatitis C virus-infected mothers." J Pediatr 126(4): 589-91.
Lin, H. H. and T. Y. Lee, et al. (1987). "Transplacental leakage of HBeAg-positive maternal blood as the most likely route  in causing intrauterine infection with hepatitis B virus." J Pediatr 111(6 Pt 1): 877-81.
Chen, C. H. and G. T. Huang, et al. (2006). "Hepatitis B- and C-related hepatocellular carcinomas yield different clinical features and prognosis." Eur J Cancer 42(15): 2524-9.
Huang, Y. W. and T. C. Wang, et al. (2015). "Increased risk of hepatocellular carcinoma in chronic hepatitis C patients with new onset diabetes: a nation-wide cohort study." Aliment Pharmacol Ther 42(7): 902-11.
Kao, J. H. and D. S. Chen (2002). "Recent updates in hepatitis vaccination and the prevention of hepatocellular carcinoma." Int J Cancer 97(3): 269-71.
Hwang, L. H. and C. L. Hsieh, et al. (1998). "Involvement of the 5' proximal coding sequences of hepatitis C virus with internal initiation of viral translation." Biochem Biophys Res Commun 252(2): 455-60.
Chang, M. H. and P. J. Chen, et al. (1991). "Hepatitis B virus integration in hepatitis B virus-related hepatocellular carcinoma in childhood." Hepatology 13(2): 316-20.
Lin, H. H. and H. Y. Hsu, et al. (1993). "Hepatitis B virus in the colostra of HBeAg-positive carrier mothers." J Pediatr Gastroenterol Nutr 17(2): 207-10.
Mah, Y. H. and C. S. Hsu, et al. (2011). "Serum p53 gene polymorphisms and severity of hepatitis B or C-related chronic liver diseases in Taiwan." Hepatol Int 5(3): 814-21.
Liu, C. J. and J. H. Kao, et al. (2004). "Precore/core promoter mutations and genotypes of hepatitis B virus in chronic hepatitis B patients with fulminant or subfulminant hepatitis." J Med Virol 72(4): 545-50.
Ni, Y. H. and M. H. Chang, et al. (2012). "Minimization of hepatitis B infection by a 25-year universal vaccination program." J Hepatol 57(4): 730-5.
Kao, J. H. and W. Chen, et al. (1999). "Prevalence and implication of TT virus infection: minimal role in patients with non-A-E hepatitis in Taiwan." J Med Virol 59(3): 307-12.
Chen, D. S. (1995). "Hepatitis C virus in chronic liver disease and hepatocellular carcinoma in Taiwan." Princess Takamatsu Symp 25: 27-32.
Hsu, H. C. and M. Z. Wu, et al. (1987). "Childhood hepatocellular carcinoma develops exclusively in hepatitis B surface antigen carriers in three decades in Taiwan. Report of 51 cases strongly associated with rapid development of liver cirrhosis." J Hepatol 5(3): 260-7.
Liu, C. J. and B. F. Chen, et al. (2006). "Role of hepatitis B virus precore/core promoter mutations and serum viral load on noncirrhotic hepatocellular carcinoma: a case-control study." J Infect Dis 194(5): 594-9.
Wang, S. H. and S. H. Yeh, et al. (2015). "Sorafenib Action in Hepatitis B Virus X-Activated Oncogenic Androgen Pathway in Liver through SHP-1." J Natl Cancer Inst 107(10).
Kao, J. H. and P. J. Chen, et al. (2002). "Clinical and virological aspects of blood donors infected with hepatitis B virus  genotypes B and C." J Clin Microbiol 40(1): 22-5.
Chen, H. L. and M. H. Chang, et al. (1998). "Antibodies to E2 protein of hepatitis G virus in children: different responses according to age at infection." J Pediatr 133(3): 382-5.
Tzen, K. T. and M. H. Chang, et al. (1991). "Hepatitis A virus infection in Taipei City in 1989." J Formos Med Assoc 90(2): 138-40.
Horng, Y. C. and M. H. Chang, et al. (1993). "Safety and immunogenicity of hepatitis A vaccine in healthy adult volunteers." J Gastroenterol Hepatol 8(4): 338-41.
Liu, C. H. and C. C. Liang, et al. (2011). "Transient elastography to assess hepatic fibrosis in hemodialysis chronic hepatitis C patients." Clin J Am Soc Nephrol 6(5): 1057-65.
Mu, J. J. and Y. G. Tsay, et al. (2004). "The small delta antigen of hepatitis delta virus is an acetylated protein and acetylation of lysine 72 may influence its cellular localization and viral RNA synthesis." Virology 319(1): 60-70.
Liu, C. J. and H. R. Cheng, et al. (2011). "Effects of hepatitis B virus precore and basal core promoter mutations on the expression of viral antigens: genotype B vs C." J Viral Hepat 18(10): e482-90.
Chang, M. H. and H. Y. Hsu, et al. (1998). "Precore stop codon mutant in chronic hepatitis B virus infection in children: its relation to hepatitis B e seroconversion and maternal hepatitis B surface antigen." J Hepatol 28(6): 915-22.
Kao, J. H. and P. M. Yang, et al. (1995). "Evaluation of third-generation hepatitis C antibody assay in chronic hepatitis C  and chronic non-B, non-C hepatitis." Viral Immunol 8(3): 135-9.
Liu, C. J. and J. H. Kao, et al. (2006). "Overlap lamivudine treatment in patients with chronic hepatitis B receiving adefovir for lamivudine-resistant viral mutants." J Viral Hepat 13(6): 387-95.
Liu, C. J. and P. J. Chen, et al. (2016). "Perspectives on dual hepatitis B and C infection in Taiwan." J Formos Med Assoc 115(5): 298-305.
Kao, J. H. and M. Y. Lai, et al. (2001). "Prolonged interferon treatment after combination interferon and ribavirin therapy in patients with chronic hepatitis C: a clinical trial of interferon relapsers and non-responders." J Formos Med Assoc 100(10): 662-7.
Lai, M. Y. and J. H. Kao, et al. (1996). "Long-term efficacy of ribavirin plus interferon alfa in the treatment of chronic  hepatitis C." Gastroenterology 111(5): 1307-12.
Chen, D. S. and M. Y. Lai, et al. (1991). "Hepatitis D virus infection in a hyperendemic area of chronic hepatitis B virus infection: the Taiwan experience." Prog Clin Biol Res 364: 75-80.
Chen, P. J. and L. H. Hwang, et al. (1993). "Immunoglobulin M antibodies against hepatitis C virus antigens: significance and  applications." Gastroenterol Jpn 28 Suppl 5: 67-70.
Huang, L. M. and C. Y. Lu, et al. (2011). "Hepatitis B virus infection, its sequelae, and prevention by vaccination." Curr Opin Immunol 23(2): 237-43.
Lee, R. S. and S. J. Hsu, et al. (2004). "Induction of humoral and cellular immune responses to hepatitis delta virus through DNA immunization in BALB/c mice." Methods Mol Med 96: 111-28.
Lin, C. L. and T. C. Tseng, et al. (2012). "Host genetic variants and hepatitis B virologic features in HBeAg-negative hepatitis B carriers with long-term biochemical remission." Hepatol Int 6(3): 598-605.
Kao, J. H. and P. J. Chen, et al. (1998). "Effects of GB virus-C/hepatitis G virus on hepatitis B and C viremia in multiple  hepatitis virus infections." Arch Virol 143(4): 797-802.
Wang, C. C. and L. H. Hwang, et al. (1995). "Unbiased usage of T-cell receptor beta variable region genes in peripheral blood  cells of hepatitis C patients: no correlation with superantigen effect." J Med Virol 45(1): 24-8.
Lin, H. H. and W. Y. Wu, et al. (2006). "Hepatitis B post-partum e antigen clearance in hepatitis B carrier mothers: Correlation with viral characteristics." J Gastroenterol Hepatol 21(3): 605-9.
Liu, C. H. and C. F. Huang, et al. (2015). "Peginterferon plus weight-based ribavirin for treatment-naive hepatitis C virus genotype 2 patients not achieving rapid virologic response: a randomized trial." Sci Rep 5: 11710.
Fang, S. H. and M. Y. Lai, et al. (2001). "Ribavirin enhances interferon-gamma levels in patients with chronic hepatitis C treated with interferon-alpha." J Biomed Sci 8(6): 484-91.
Kao, J. H. and P. J. Chen, et al. (1996). "Superinfection by homotypic virus in hepatitis C virus carriers: studies on patients with post-transfusion hepatitis." J Med Virol 50(4): 303-8.
Shih, L. N. and J. C. Sheu, et al. (1990). "Serum hepatitis B virus DNA in healthy HBsAg-negative Chinese adults evaluated by polymerase chain reaction." J Med Virol 32(4): 257-60.
Horng, Y. C. and M. H. Chang, et al. (1993). "Safety and immunogenicity of hepatitis A vaccine in healthy children." Pediatr Infect Dis J 12(5): 359-62.
Su, T. H. and C. S. Hsu, et al. (2010). "Serum hepatitis B surface antigen concentration correlates with HBV DNA level in  patients with chronic hepatitis B." Antivir Ther 15(8): 1133-9.
Chen, H. L. and C. J. Chang, et al. (2004). "Pediatric fulminant hepatic failure in endemic areas of hepatitis B infection: 15 years after universal hepatitis B vaccination." Hepatology 39(1): 58-63.
Pan, C. J. and H. L. Wu, et al. (2012). "Serum interleukin 6 level correlates with outcomes of acute exacerbation of chronic hepatitis B." Hepatol Int 6(3): 591-7.
Lin, H. H. and J. H. Kao, et al. (1998). "Mother-to-infant transmission of GB virus C/hepatitis G virus: the role of high-titered maternal viremia and mode of delivery." J Infect Dis 177(5): 1202-6.
Chen, P. J. and M. L. Chen, et al. (1994). "A Viral Mechanism in Acute Exacerbations of Chronic Type B Hepatitis: Hepatitis B Virus Reinfection and Subsequent Reactivation of Two Viral Strains." J Biomed Sci 1(1): 7-12.
Lee, I. N. and C. H. Chen, et al. (2006). "Identification of complement C3a as a candidate biomarker in human chronic hepatitis C and HCV-related hepatocellular carcinoma using a proteomics approach." Proteomics 6(9): 2865-73.
Locarnini, S. and A. Hatzakis, et al. (2015). "Strategies to control hepatitis B: Public policy, epidemiology, vaccine and drugs." J Hepatol 62(1 Suppl): S76-86.
Ni, Y. H. and M. H. Chang, et al. (2001). "Hepatitis B virus infection in children and adolescents in a hyperendemic area: 15 years after mass hepatitis B vaccination." Ann Intern Med 135(9): 796-800.
Kao, J. H. and Y. T. Hwang, et al. (1996). "Transmission of hepatitis C virus between spouses: the important role of exposure duration." Am J Gastroenterol 91(10): 2087-90.
Lee, P. I. and M. H. Chang, et al. (1990). "Changes of serum hepatitis B virus DNA and aminotransferase levels during the course of chronic hepatitis B virus infection in children." Hepatology 12(4 Pt 1): 657-60.
Kuo, M. Y. and L. J. Hahn, et al. (1993). "Low prevalence of hepatitis C virus infection among dentists in Taiwan." J Med Virol 40(1): 10-3.
Kao, J. H. and P. J. Chen, et al. (2010). "Recent advances in the research of hepatitis B virus-related hepatocellular carcinoma: epidemiologic and molecular biological aspects." Adv Cancer Res 108: 21-72.











欢迎光临 中国病毒学论坛|我们一直在坚持! (http://virology.com.cn/) Powered by Discuz! X3.2