标题: 计算机辅助疫苗设计Computer-Aided Vaccine Design [打印本页] 作者: randomqd 时间: 2016-8-16 12:18 标题: 计算机辅助疫苗设计Computer-Aided Vaccine Design 本帖最后由 randomqd 于 2016-8-16 12:20 编辑 * m! Y* ^; U, b2 i# n6 V - C/ Y2 u4 V) g9 U1st Edition, p: B3 ]) A6 @- i) T; X
Authors: Joo Chuan Tong Shoba Ranganathan & k P$ _: ^' iElectronic ISBN 9781908818416 Print ISBN 9781907568411+ }: W% E; B) s: I
2 W" M! V% T8 Y |8 b1 n% t Description 3 G; T P: R9 V5 M! yComputational pre-screening of antigens is now routinely applied to the discovery of vaccine candidates. 9 ?7 j3 E, B. ]" `; [$ _Computer-aided vaccine design is a comprehensive introduction to this exciting field of study. The book is intended to be a textbook for researchers and for courses in bioinformatics, as well as a laboratory reference guide. It is written mainly for biologists who want to understand the current methods of computer-aided vaccine design. The contents are designed to help biologists appreciate the underlying concepts and algorithms used, as well as limitations of the methods and strategies for their use. Chapters include: MHC and T cell responses; Immunoglobulins and B cell responses; Scientific publications and databases; Database design; Computational T cell vaccine design; Computational B cell vaccine design; infectious disease informatics; Vaccine safety and quality assessments; and Vaccine adjuvant informatics.6 }1 v y# ?3 {' V w& Z
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1 ~( `+ S8 J9 x4 o1 @* D; H, kTable of Contents7 d/ ^" ]2 j/ T, F
List of figures 8 P3 Q! S: F, S' C4 a; B) L. }List of abbreviations3 ]3 @5 A4 F5 C0 d' g
About the authors F" S; k. n8 o$ i2 y
Preface # C4 | [! O3 g7 x* [7 H* MChapter 1: MHC and T cell responses + H- v6 ~; [* D5 c: @' yAbstract:7 M5 }! A# M- X7 o. o( W- I
1.1 Genetic organization of the MHC% G' Q0 O0 g. J s
1.2 MHC structure ) U: t' m2 f; Y# `8 A! B: A% X1.3 MHC function0 f; g z3 n+ F8 w8 m5 I
1.4 Peptide binding / w4 O: D$ S" C; ]# _ MChapter 2: Immunoglobulins and B cell responses6 a" q. B2 V" \/ o' @
Abstract: ; Z# [1 h6 m5 }1 P2.1 Types of immunoglobulins8 K9 @0 H/ m2 T0 x0 U5 C
2.2 Immunoglobulin structure/ T* Y9 {& J7 ?; G
2.3 Immunoglobulin function/ S3 Q1 F1 b' W- T) Y
2.4 Antigen binding + S; P& G O0 w4 J) d" I# ~$ @Chapter 3: Scientific publications and databases4 S1 @$ i# S5 y& s" b! E
Abstract:1 @6 N7 d8 n" T6 ~7 `
3.1 Bibliographical information! e5 {. r' v: `7 ~! f% \* N4 t
3.2 Searching the literature& x7 a2 ^3 o+ Y+ J3 O' ~! ^& K
3.3 General databases containing information on genes and proteins . \4 S" @& W) t i3 p% K3.4 Immunological databases . e$ N- b2 j. Z3.5 Small molecule databases $ F6 j- G; {. ~" x4 ~0 r. YChapter 4: Database design . e6 @3 x+ a# L4 }! D5 j" jAbstract:- z4 C4 B8 Y. E9 m% |/ K8 j
4.1 Fundamentals of database design ) y) T$ \7 J1 Y' h# z& ]: P4.2 ER diagram 5 }* J% M( Y' B1 T4.3 Normalization and normal forms1 q* @' N) J. [' o% k0 c
Chapter 5: Computational T cell vaccine design, m* i* I6 s& P9 E
Abstract:. b+ l1 ~1 k% A: d1 p
5.1 Sequence-based methods 8 S$ n$ F& W4 y$ g0 k1 J5.2 Structure-based methods! H% t! E; O& T+ D4 F
5.3 Broad-based T cell vaccine design w9 {3 K c% r, h' }2 hChapter 6: Computational B cell vaccine design ) G" `. l. N: u3 u6 N% zAbstract:! L A( r0 Y; e3 o) W0 N" p) R
6.1 Sequence-based methods9 I/ K- U9 ~" N i9 x( A9 r
6.2 Structure-based methods# F; w& V6 g# Y" G4 c2 `9 Q7 t
Chapter 7: Infectious disease informatics $ \4 z" P0 i, u$ s* EAbstract: # _7 a/ Q3 [4 x7 }' `7.1 Infectious diseases in history: K, S5 g* C, w* ~
7.2 Microbial sequence analysis4 k8 d) f7 d( `4 C9 n
7.3 Detecting natural selection in molecular evolution : j# B9 N6 R! e/ Z5 S# @" q! ?Chapter 8: Vaccine safety and quality assessments& m' o5 s5 G6 D: d- T! k
Abstract: 6 M: M# `0 V0 ]9 `8.1 Assessment of ADME/Tox deficiencies + ]+ w) K; e) s* h9 M: m8.2 Assessment of allergenicity 0 W, M+ Y2 U3 F' ]. }Chapter 9: Vaccine adjuvant informatics$ h( |: o8 l* d' {4 S2 d+ I2 v3 J
Abstract:0 L7 @: g& M, M8 p& M% t/ `
9.1 Virtual combinatorial library6 b3 s& I, s5 h. ^
9.2 Chemical file formats ! x1 n6 k3 F/ ^9.3 Considerations for virtual library design* Y# l1 u. Z( C; O; r+ i: _
Index 5 k1 i. a+ n9 W6 H% N" u+ j( L8 G1 f7 P
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