标题: Antiviral B cell and T cell immunity in the lungs [打印本页] 作者: zszhao 时间: 2015-4-23 23:02 标题: Antiviral B cell and T cell immunity in the lungs http://www.nature.com/ni/journal/v16/n1/full/ni.3056.html，求帮忙下载作者: marine0425030 时间: 2015-4-24 08:48 本帖最后由 marine0425030 于 2015-4-24 08:50 编辑 + y# k# _0 `" t6 r
" F" }% a6 V: I0 Z. `请查收！ 6 D# o7 r+ \6 ~ " h2 X3 I8 i& E: s5 o3 ?+ t + O- `4 R* c8 h4 M+ g2 {Antiviral B cell and T cell immunity in the lungs. A5 b! `2 g8 c6 j* D
, Q; }/ g5 U% l8 O: a0 v
Christopher Chiu & Peter J Opensha . f( r, I! E0 g9 l7 _/ ?/ A4 y" W3 h3 Z
Respiratory viruses are frequent causes of repeated common colds, bronchitis and pneumonia, which often occur unpredictably as epidemics and pandemics. Despite those decimating effects on health and decades of intensive research, treatments remain largely supportive. The only commonly available vaccines are against influenza virus, and even these need improvement. The lung shares some features with other mucosal sites, but preservation of its especially delicate anatomical structures necessitates a fine balance of pro- and anti-inflammatory responses; well-timed, appropriately placed and tightly regulated T cell and B cell responses are essential for protection from infection and limitation of symptoms, whereas poorly regulated inflammation contributes to tissue damage and disease. Recent advances in understanding adaptive immunity should facilitate vaccine development and reduce the global effect of respiratory viruse. R3 N+ w8 E( t& f/ ?
4 M3 Y' w' L# C+ R( h
& ?5 P% h; z6 j
7 O3 m9 G! D; ~) ^8 c, ~, z2 d 0 k z# @( H o2 k ~ f" [8 T( u8 G# x0 R