标题: [Journal Club] 每周一篇review， 9， Jan-16， Jan [打印本页] 作者: donggua 时间: 2015-7-19 16:47 标题: [Journal Club] 每周一篇review， 9， Jan-16， Jan Cellular Remodeling During plant virus infection
Jean-Franc¸ois Lalibert′e1,∗ and H′el`ene Sanfac¸on2
This review focuses on the extensive membrane and organelle rearrangements
that have been observed in plant cells infected with RNA
viruses. Themodifications generally involve the formation of spherules,
vesicles, and/or multivesicular bodies associated with various organelles
such as the endoplasmic reticulum and peroxisomes. These virusinduced
organelles house the viral RNA replication complex and are
known as virus factories or viroplasms. Membrane and organelle alterations
are attributed to the action of one or two viral proteins, which
additionally act as a scaffold for the assembly of a large complex of proteins
of both viral and host origin and viral RNA. Some virus factories
have been shown to align with and traffic along microfilaments. In addition
to viral RNA replication, the factories may be involved in other
processes such as viral RNA translation and cell-to-cell virus transport.
Confining the process of RNA replication to a specific location may
also prevent the activation of certain host defense functions.