Cell最新综述：
Origins and Mechanisms of miRNAs and siRNAs
Richard W. Carthew1,,andErik J. Sontheimer1,,
1 Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University, 2205 Tech Drive, Evanston, IL 60208-3500, USA
Summary
Over the last decade, 2030 nucleotide RNA molecules have emerged as critical regulators in the expression and function of eukaryotic genomes. Two primary categories of these small RNAsshort interfering RNAs (siRNAs) and microRNAs (miRNAs)act in both somatic and germline lineages in a broad range of eukaryotic species to regulate endogenous genes and to defend the genome from invasive nucleic acids. Recent advances have revealed unexpected diversity in their biogenesis pathways and the regulatory mechanisms that they access. Our understanding of siRNA- and miRNA-based regulation has direct implications for fundamental biology as well as disease etiology and treatment. http://www.cell.com/abstract/S0092-8674%2809%2900083-X