标题: 丙型肝炎病毒不同标志物检测结果的相关性分析 [打印本页] 作者: wwwkkk83 时间: 2015-10-22 08:56 标题: 丙型肝炎病毒不同标志物检测结果的相关性分析 丙型肝炎病毒不同标志物检测结果的相关性分析
Analysis of correlation to detected results for different hepatitis C virus markers
Abstract：
Objective To analyze correlation to the laboratory detected results for hepatitis C virus ( HCV) antigen, antibod-y, and RNA markers, and evaluate the detection methods for blood screening and joint detection of HCV infection in early clinical diagnosis.Methods HCV RNA loads, HCV Ag and anti-HCV index of plasma samples from 304 cases were detec-ted by HCV RNA quantitative reagents, HCV core antigen reagents, and HCV antibody reagents from Abbott, and the genetic typing of HCV RNA positive samples was conducted.Results Among the 304 plasma samples, 87 were detected HCV RNA positive.While the HCV RNA loads were≥500 IU/mL, between 500 and 30 IU/mL, and <30 IU/mL, samples with the positive rate of HCV Ag concentration≥3 fmol/L and anti-HCV signal value/judgment value ≥1 were 92.0% (23/25):96.0%(24/25);58.8%(10/17):82.3%(14/17);11.1%(5/45):75.6%(34/45), respectively.The genetic typing rate was 24.2%(15/62)when the HCV RNA loads were lower than the 500 IU/mL LOD standard of genetic typing reagent. Among the 217 HCV RNA negative samples, the positive rate of HCV Ag concentration≥3 fmol/L and anti-HCV signal val-ue/judgment value≥1 samples were 3.2%(7/217), 32.7%(71/217), respectively.The difference for positive rates of serological indicators in different HCV RNA loads is statistically significant (χ2=197.4, P<0.01).There is positive correla-tion to HCV RNA loads and HCVAg, anti-HCV.Conclusion There are HCV carriers with low HCV RNA loads in popula-tion of China.The detectability of HCVAg and genetic typing need to be improved.