Jing-hsiung James Ou，南加州大学——HBV相关实验室及人物介绍

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Jing-hsiung James Ou，南加州大学——HBV相关实验室及人物介绍系列

Jing-hsiung James Ou，University of Southern California
美国研究乙肝的一个常青树

Tian, Y. and J. H. Ou (2015). "Genetic and epigenetic alterations in hepatitis B virus-associated hepatocellular carcinoma." Virol Sin 30(2): 85-91.
Lee, J. and Y. Tian, et al. (2015). "TNF-alpha Induced by Hepatitis C Virus via TLR7 and TLR8 in Hepatocytes Supports  Interferon Signaling via an Autocrine Mechanism." PLoS Pathog 11(5): e1004937.
Slagle, B. L. and O. M. Andrisani, et al. (2015). "Technical standards for hepatitis B virus X protein (HBx) research." Hepatology 61(4): 1416-24.
(2012). "Hepatitis C virus translation preferentially depends on active RNA replication." 7(8): e43600.
Liu, Z. and Y. Tian, et al. (2012). "Transient activation of the PI3K-AKT pathway by hepatitis C virus to enhance viral entry." J Biol Chem 287(50): 41922-30.
(2012). "Viral-load-dependent effects of liver injury and regeneration on hepatitis B virus replication in mice." 86(18): 9599-605.
Wang, Q. and B. Na, et al. (2012). "Hepatitis B virus alters the antioxidant system in transgenic mice and sensitizes hepatocytes to Fas signaling." PLoS One 7(5): e36818.
Sir D and C. F. Kuo, et al. (2012). "Replication of hepatitis C virus RNA on autophagosomal membranes." J Biol Chem 287(22): 18036-43.
Tian, Y. and C. F. Kuo, et al. (2012). "Enhancement of hepatitis B virus replication by androgen and its receptor in mice." J Virol 86(4): 1904-10.
Tian, Y. and Sir D, et al. (2011). "Autophagy required for hepatitis B virus replication in transgenic mice." J Virol 85(24): 13453-6.
Kido, T. and J. H. Ou, et al. (2011). "The X-linked tumor suppressor TSPX interacts and promotes degradation of the hepatitis B viral protein HBx via the proteasome pathway." PLoS One 6(7): e22979.
Zhou, J. and T. Tan, et al. (2011). "Kruppel-like factor 15 activates hepatitis B virus gene expression and replication." Hepatology 54(1): 109-21.
Na, B. and Z. Huang, et al. (2011). "Transgenic expression of entire hepatitis B virus in mice induces hepatocarcinogenesis independent of chronic liver injury." PLoS One 6(10): e26240.
Machida, K. and G. McNamara, et al. (2010). "Hepatitis C virus inhibits DNA damage repair through reactive oxygen and nitrogen species and by interfering with the ATM-NBS1/Mre11/Rad50 DNA repair pathway in monocytes and hepatocytes." J Immunol 185(11): 6985-98.
Machida, K. and H. Tsukamoto, et al. (2010). "c-Jun mediates hepatitis C virus hepatocarcinogenesis through signal transducer and activator of transcription 3 and nitric oxide-dependent impairment of oxidative DNA repair." Hepatology 52(2): 480-92.
Zhang, Z. and E. Sun, et al. (2010). "Inhibition of cellular proteasome activities mediates HBX-independent hepatitis B virus replication in vivo." J Virol 84(18): 9326-31.
Wu, M. H. and W. L. Ma, et al. (2010). "Androgen receptor promotes hepatitis B virus-induced hepatocarcinogenesis through modulation of hepatitis B virus RNA transcription." Sci Transl Med 2(32): 32ra35.
Sir D and D. K. Ann, et al. (2010). "Autophagy by hepatitis B virus and for hepatitis B virus." Autophagy 6(4): 548-9.
Sir D and Y. Tian, et al. (2010). "The early autophagic pathway is activated by hepatitis B virus and required for viral DNA replication." Proc Natl Acad Sci U S A 107(9): 4383-8.
Yuksek, K. and W. L. Chen, et al. (2009). "Ubiquitin-independent degradation of hepatitis C virus F protein." J Virol 83(2): 612-21.
Sir D and W. L. Chen, et al. (2008). "Induction of incomplete autophagic response by hepatitis C virus via the unfolded protein response." Hepatology 48(4): 1054-61.
Sir D and C. Liang, et al. (2008). "Perturbation of autophagic pathway by hepatitis C virus." Autophagy 4(6): 830-1.
Ma, H. C. and T. W. Lin, et al. (2008). "Hepatitis C virus ARFP/F protein interacts with cellular MM-1 protein and enhances the gene trans-activation activity of c-Myc." J Biomed Sci 15(4): 417-25.
Zheng, Y. and W. L. Chen, et al. (2007). "Hepatitis B virus promotes hepatocarcinogenesis in transgenic mice." Hepatology 45(1): 16-21.
Zheng, Y. and W. L. Chen, et al. (2007). "Enhancement of gene transactivation activity of androgen receptor by hepatitis B  virus X protein." Virology 363(2): 454-61.
Choi, J. and H. J. Forman, et al. (2006). "Redox modulation of the hepatitis C virus replication complex is calcium dependent." Free Radic Biol Med 41(9): 1488-98.
Choi, J. and J. H. Ou (2006). "Mechanisms of liver injury. III. Oxidative stress in the pathogenesis of hepatitis C virus." Am J Physiol Gastrointest Liver Physiol 290(5): G847-51.
Zheng, Y. and X. D. Fu, et al. (2005). "Suppression of hepatitis B virus replication by SRPK1 and SRPK2 via a pathway independent of the phosphorylation of the viral core protein." Virology 342(1): 150-8.
Zheng, Y. and J. Li, et al. (2004). "Regulation of hepatitis B virus core promoter by transcription factors HNF1 and HNF4 and the viral X protein." J Virol 78(13): 6908-14.
Lee, K. J. and J. Choi, et al. (2004). "The C-terminal transmembrane domain of hepatitis C virus (HCV) RNA polymerase is  essential for HCV replication in vivo." J Virol 78(7): 3797-802.
Xu, Z. and J. H. Ou (2004). "Endogenous polymerase assay for the analysis of hepatitis B virus in transgenic mice." Methods Mol Med 95: 295-302.
Li, J. and Y. Zheng, et al. (2004). "Phosphorylation analysis of hepatitis B virus core protein in mammalian cells." Methods Mol Med 95: 227-33.
Choi, J. and K. J. Lee, et al. (2004). "Reactive oxygen species suppress hepatitis C virus RNA replication in human hepatoma cells." Hepatology 39(1): 81-9.
Kojima, H. and K. D. Kaita, et al. (2003). "The absence of up-regulation of telomerase activity during regeneration after partial hepatectomy in hepatitis B virus X gene transgenic mice." J Hepatol 39(2): 262-8.
Zheng, Y. and J. Li, et al. (2003). "Regulation of hepatitis B virus replication by the ras-mitogen-activated protein  kinase signaling pathway." J Virol 77(14): 7707-12.
Choi, J. and Z. Xu, et al. (2003). "Triple decoding of hepatitis C virus RNA by programmed translational frameshifting." Mol Cell Biol 23(5): 1489-97.
Lin, W. J. and J. Li, et al. (2003). "Suppression of hepatitis B virus core promoter by the nuclear orphan receptor TR4." J Biol Chem 278(11): 9353-60.
Xu, Z. and J. Choi, et al. (2003). "Hepatitis C virus f protein is a short-lived protein associated with the endoplasmic reticulum." J Virol 77(2): 1578-83.
Yamaga, A. K. and J. H. Ou (2002). "Membrane topology of the hepatitis C virus NS2 protein." J Biol Chem 277(36): 33228-34.
Li, J. and Z. Xu, et al. (2002). "Regulation of hepatocyte nuclear factor 1 activity by wild-type and mutant hepatitis B virus X proteins." J Virol 76(12): 5875-81.
Xu, Z. and T. S. Yen, et al. (2002). "Enhancement of hepatitis B virus replication by its X protein in transgenic mice." J Virol 76(5): 2579-84.
Lu, W. and J. H. Ou (2002). "Phosphorylation of hepatitis C virus core protein by protein kinase A and protein kinase C." Virology 300(1): 20-30.
Lu, W. and A. Strohecker, et al. (2001). "Post-translational modification of the hepatitis C virus core protein by tissue transglutaminase." J Biol Chem 276(51): 47993-9.
Li, J. and J. H. Ou (2001). "Differential regulation of hepatitis B virus gene expression by the Sp1 transcription factor." J Virol 75(18): 8400-6.
Lu, W. and S. Y. Lo, et al. (1999). "Activation of p53 tumor suppressor by hepatitis C virus core protein." Virology 264(1): 134-41.
Li, J. and V. E. Buckwold, et al. (1999). "Mechanism of suppression of hepatitis B virus precore RNA transcription by a frequent double mutation." J Virol 73(2): 1239-44.
Lo, S. Y. and J. H. Ou (1999). "Expression and Dimerization of Hepatitis C Virus Core Protein in E. coli." Methods Mol Med 19: 325-30.
Ou, J. H. (1997). "Molecular biology of hepatitis B virus e antigen." J Gastroenterol Hepatol 12(9-10): S178-87.
Buckwold, V. E. and Z. Xu, et al. (1997). "Effects of a frequent double-nucleotide basal core promoter mutation and its putative single-nucleotide precursor mutations on hepatitis B virus gene expression and replication." J Gen Virol 78 ( Pt 8): 2055-65.
Matsumoto, M. and T. Y. Hsieh, et al. (1997). "Hepatitis C virus core protein interacts with the cytoplasmic tail of lymphotoxin-beta receptor." J Virol 71(2): 1301-9.
Buckwold, V. E. and M. Chen, et al. (1997). "Interaction of transcription factors RFX1 and MIBP1 with the gamma motif of the negative regulatory element of the hepatitis B virus core promoter." Virology 227(2): 515-8.
Buckwold, V. E. and Z. Xu, et al. (1996). "Effects of a naturally occurring mutation in the hepatitis B virus basal core promoter on precore gene expression and viral replication." J Virol 70(9): 5845-51.
Lo, S. Y. and M. J. Selby, et al. (1996). "Interaction between hepatitis C virus core protein and E1 envelope protein." J Virol 70(8): 5177-82.
Yeh, C. T. and L. H. Hong, et al. (1996). "Characterization of nuclear localization of a hepatitis B virus precore protein derivative P22." Arch Virol 141(3-4): 425-38.
Chen, M. and J. H. Ou (1995). "Cell type-dependent regulation of the activity of the negative regulatory element of the hepatitis B virus core promoter." Virology 214(1): 198-206.
Lo, S. Y. and F. Masiarz, et al. (1995). "Differential subcellular localization of hepatitis C virus core gene products." Virology 213(2): 455-61.
Hwang, S. B. and S. Y. Lo, et al. (1995). "Detection of Cellular Proteins and Viral Core Protein Interacting with the 5' Untranslated Region of Hepatitis C Virus RNA." J Biomed Sci 2(3): 227-236.
Lu, C. C. and M. Chen, et al. (1995). "Key role of a CCAAT element in regulating hepatitis B virus surface protein expression." Virology 206(2): 1155-8.
Liao, W. and J. H. Ou (1995). "Phosphorylation and nuclear localization of the hepatitis B virus core protein: significance of serine in the three repeated SPRRR motifs." J Virol 69(2): 1025-9.
Chen, M. and S. Hieng, et al. (1994). "Regulation of hepatitis B virus ENI enhancer activity by hepatocyte-enriched transcription factor HNF3." Virology 205(1): 127-32.
Yeh, C. T. and J. H. Ou, et al. (1994). "Alteration of the subcellular localization of hepatitis B virus core protein by large but not small surface proteins." Biochem Biophys Res Commun 203(2): 1348-54.
Yeh, C. T. and C. M. Han, et al. (1994). "Early detection of anti-HCc antibody in acute hepatitis C virus (HCV) by western  blot (immunoblot) using a recombinant HCV core protein fragment." J Clin Microbiol 32(9): 2235-41.
Lo, S. Y. and M. Selby, et al. (1994). "Comparative studies of the core gene products of two different hepatitis C virus  isolates: two alternative forms determined by a single amino acid substitution." Virology 199(1): 124-31.
Yeh, C. T. and S. W. Wong, et al. (1993). "Cell cycle regulation of nuclear localization of hepatitis B virus core protein." Proc Natl Acad Sci U S A 90(14): 6459-63.
Guo, W. and M. Chen, et al. (1993). "Hepatocyte-specific expression of the hepatitis B virus core promoter depends on  both positive and negative regulation." Mol Cell Biol 13(1): 443-8.
Xia, Y. P. and C. T. Yeh, et al. (1992). "Characterization of nuclear targeting signal of hepatitis delta antigen: nuclear  transport as a protein complex." J Virol 66(2): 914-21.
Wang, J. and A. S. Lee, et al. (1991). "Proteolytic conversion of hepatitis B virus e antigen precursor to end product occurs in a postendoplasmic reticulum compartment." J Virol 65(9): 5080-3.
Yeh, C. T. and J. H. Ou (1991). "Phosphorylation of hepatitis B virus precore and core proteins." J Virol 65(5): 2327-31.
Guo, W. T. and K. D. Bell, et al. (1991). "Characterization of the hepatitis B virus EnhI enhancer and X promoter complex." J Virol 65(12): 6686-92.
Yeh, C. T. and Y. F. Liaw, et al. (1990). "The arginine-rich domain of hepatitis B virus precore and core proteins contains  a signal for nuclear transport." J Virol 64(12): 6141-7.
Ou, J. H. and H. Bao, et al. (1990). "Preferred translation of human hepatitis B virus polymerase from core protein- but not from precore protein-specific transcript." J Virol 64(9): 4578-81.
Zhou, D. X. and A. Taraboulos, et al. (1990). "Activation of class I major histocompatibility complex gene expression by hepatitis B virus." J Virol 64(8): 4025-8.
Ou, J. H. and K. D. Bell (1990). "Comparative studies of hepatitis B virus precore and core particles." Virology 174(1): 185-91.
Ou, J. H. and C. T. Yeh, et al. (1989). "Transport of hepatitis B virus precore protein into the nucleus after cleavage of its signal peptide." J Virol 63(12): 5238-43.
Standring, D. N. and J. H. Ou, et al. (1988). "A signal peptide encoded within the precore region of hepatitis B virus directs the secretion of a heterogeneous population of e antigens in Xenopus oocytes." Proc Natl Acad Sci U S A 85(22): 8405-9.
Seto, E. and T. S. Yen, et al. (1988). "Trans-activation of the human immunodeficiency virus long terminal repeat by the  hepatitis B virus X protein." Proc Natl Acad Sci U S A 85(21): 8286-90.
Garcia, P. D. and J. H. Ou, et al. (1988). "Targeting of the hepatitis B virus precore protein to the endoplasmic reticulum membrane: after signal peptide cleavage translocation can be aborted and the product released into the cytoplasm." J Cell Biol 106(4): 1093-104.
Ou, J. H. and W. J. Rutter (1987). "Regulation of secretion of the hepatitis B virus major surface antigen by the preS-1 protein." J Virol 61(3): 782-6.
Wang, K. S. and O. L. Choo, et al. (1987). "The viroid-like structure of the hepatitis delta (delta) genome: synthesis of a viral antigen in recombinant bacteria." Prog Clin Biol Res 234: 71-82.
Wang, K. S. and Q. L. Choo, et al. (1986). "Structure, sequence and expression of the hepatitis delta (delta) viral genome." Nature 323(6088): 508-14.
Ou, J. H. and O. Laub, et al. (1986). "Hepatitis B virus gene function: the precore region targets the core antigen to cellular membranes and causes the secretion of the e antigen." Proc Natl Acad Sci U S A 83(6): 1578-82.
Standring, D. N. and J. H. Ou, et al. (1986). "Assembly of viral particles in Xenopus oocytes: pre-surface-antigens regulate secretion of the hepatitis B viral surface envelope particle." Proc Natl Acad Sci U S A 83(24): 9338-42.