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发表于 2015-9-23 23:30:34
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Science. 2015 Sep 18;349(6254):1338-43. doi: 10.1126/science.aac5017.
Dengue viruses cluster antigenically but not as discrete serotypes.
Katzelnick LC1, Fonville JM2, Gromowski GD3, Arriaga JB3, Green A4, James SL5, Lau L4, Montoya M4, Wang C4, VanBlargan LA3, Russell CA6, Thu HM7, Pierson TC3, Buchy P8, Aaskov JG9, Muñoz-Jordán JL10, Vasilakis N11, Gibbons RV12, Tesh RB11, Osterhaus AD13, Fouchier RA13, Durbin A14, Simmons CP15, Holmes EC16, Harris E4, Whitehead SS3, Smith DJ17.
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Abstract
The four genetically divergent dengue virus (DENV) types are traditionally classified as serotypes. Antigenic and genetic differences among the DENV types influence disease outcome, vaccine-induced protection, epidemic magnitude, and viral evolution. We characterized antigenic diversity in the DENV types by antigenic maps constructed from neutralizing antibody titers obtained from African green monkeys and after human vaccination and natural infections. Genetically, geographically, and temporally, diverse DENV isolates clustered loosely by type, but we found that many are as similar antigenically to a virus of a different type as to some viruses of the same type. Primary infection antisera did not neutralize all viruses of the same DENV type any better than other types did up to 2 years after infection and did not show improved neutralization to homologous type isolates. That the canonical DENV types are not antigenically homogeneous has implications for vaccination and research on the dynamics of immunity, disease, and the evolution of DENV. |
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