Jack R. Wands，波士顿——HBV相关实验室及人物介绍系列

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Jack R. Wands，波士顿——HBV相关实验室及人物介绍系列

Jack R. Wands，波士顿

Ortiz, V. and J. R. Wands (2014). "Chronic ethanol diet increases regulatory T-cell activity and inhibits hepatitis  C virus core-specific cellular immune responses in mice." Hepatol Res 44(7): 788-97.
Tong, S. and J. Li, et al. (2013). "Hepatitis B virus genetic variants: biological properties and clinical implications." Emerg Microbes Infect 2(3): e10.
Yan, T. and K. Li, et al. (2011). "T1846 and A/G1913 are associated with acute on chronic liver failure in patients  infected with hepatitis B virus genotypes B and C." J Med Virol 83(6): 996-1004.
Ito, K. and Y. Qin, et al. (2010). "Impairment of hepatitis B virus virion secretion by single-amino-acid substitutions in the small envelope protein and rescue by a novel glycosylation site." J Virol 84(24): 12850-61.
von Dem, B. A. and R. Machida, et al. (2010). "Hepatitis C virus NS2 protein triggers endoplasmic reticulum stress and suppresses its own viral replication." J Hepatol 53(5): 797-804.
Szabo, G. and J. R. Wands, et al. (2010). "Alcohol and hepatitis C virus--interactions in immune dysfunctions and liver damage." Alcohol Clin Exp Res 34(10): 1675-86.
Longato, L. and S. de la Monte, et al. (2009). "Overexpression of insulin receptor substrate-1 and hepatitis Bx genes causes premalignant alterations in the liver." Hepatology 49(6): 1935-43.
Siu, L. and J. Foont, et al. (2009). "Hepatitis C virus and alcohol." Semin Liver Dis 29(2): 188-99.
Tsai, A. and S. Kawai, et al. (2009). "Chimeric constructs between two hepatitis B virus genomes confirm transcriptional impact of core promoter mutations and reveal multiple effects of core gene mutations." Virology 387(2): 364-72.
Gehring, S. and S. H. Gregory, et al. (2009). "Generation of immune responses against hepatitis C virus by dendritic cells containing NS5 protein-coated microparticles." Clin Vaccine Immunol 16(2): 163-71.
Wintermeyer, P. and J. R. Wands (2007). "Vaccines to prevent chronic hepatitis C virus infection: current experimental and preclinical developments." J Gastroenterol 42(6): 424-32.
Encke, J. and M. Geissler, et al. (2006). "DNA-based immunization breaks tolerance in a hepatitis C virus transgenic mouse model." Hum Vaccin 2(2): 78-83.
Branda, M. and J. R. Wands (2006). "Signal transduction cascades and hepatitis B and C related hepatocellular carcinoma." Hepatology 43(5): 891-902.
Kuzushita, N. and S. H. Gregory, et al. (2006). "Vaccination with protein-transduced dendritic cells elicits a sustained response  to hepatitis C viral antigens." Gastroenterology 130(2): 453-64.
Fukutomi, T. and Y. Zhou, et al. (2005). "Hepatitis C virus core protein stimulates hepatocyte growth: correlation with upregulation of wnt-1 expression." Hepatology 41(5): 1096-105.
Gehring, S. and S. H. Gregory, et al. (2005). "Type 1 interferon augments DNA-based vaccination against hepatitis C virus core protein." J Med Virol 75(2): 249-57.
Khan, N. and M. Guarnieri, et al. (2004). "Modulation of hepatitis B virus secretion by naturally occurring mutations in the S gene." J Virol 78(7): 3262-70.
Li, J. and S. Tong, et al. (2004). "Glycine decarboxylase mediates a postbinding step in duck hepatitis B virus infection." J Virol 78(4): 1873-81.
Encke, J. and P. J. Zu, et al. (2003). "CpG immuno-stimulatory motifs enhance humoral immune responses against hepatitis  C virus core protein after DNA-based immunization." Arch Virol 148(3): 435-48.
Dumoulin, F. L. and B. A. von Dem, et al. (2003). "Hepatitis C virus NS2 protein inhibits gene expression from different cellular and viral promoters in hepatic and nonhepatic cell lines." Virology 305(2): 260-6.
Heintges, T. and J. Encke, et al. (2001). "Inhibition of hepatitis C virus NS3 function by antisense oligodeoxynucleotides and protease inhibitor." J Med Virol 65(4): 671-80.
Spangenberg, H. C. and J. R. Wands (2001). "Ribozymes and hepatitis B virus." J Gastroenterol Hepatol 16(10): 1084-5.
Spangenberg, H. C. and H. B. Lee, et al. (2001). "A short sequence within domain C of duck carboxypeptidase D is critical for duck  hepatitis B virus binding and determines host specificity." J Virol 75(22): 10630-42.
Mauch, C. and C. Grimm, et al. (2001). "Induction of cytotoxic T lymphocyte responses against hepatitis delta virus antigens which protect against tumor formation in mice." Vaccine 20(1-2): 170-80.
Zu, P. J. and J. Encke, et al. (2000). "Cytotoxic T cell responses against hepatitis B virus polymerase induced by genetic immunization." J Hepatol 33(6): 986-91.
Encke, J. and J. R. Wands (2000). "Ethanol inhibition: the humoral and cellular immune response to hepatitis C virus NS5 protein after genetic immunization." Alcohol Clin Exp Res 24(7): 1063-9.
Geissler, M. and V. Bruss, et al. (1999). "Intracellular retention of hepatitis B virus surface proteins reduces interleukin-2 augmentation after genetic immunizations." J Virol 73(5): 4284-92.
Zu, P. J. and R. E. Lanford, et al. (1999). "Properties of monoclonal antibodies directed against hepatitis B virus polymerase protein." J Virol 73(5): 4188-96.
Zu, P. J. and A. Skerra, et al. (1999). "Intracellular expression of a cloned antibody fragment interferes with hepatitis  B virus surface antigen secretion." Biochem Biophys Res Commun 255(3): 785-91.
Zu, P. J. and S. Tong, et al. (1999). "A short region in the genome of hepatitis B virus is critical for maintenance of  high transcript levels." Virology 254(2): 245-56.
Wakita, T. and D. Moradpour, et al. (1999). "Antiviral effects of antisense RNA on hepatitis C virus RNA translation and expression." J Med Virol 57(3): 217-22.
Heintges, T. and P. J. Zu, et al. (1999). "Characterization and binding of intracellular antibody fragments to the hepatitis C virus core protein." Biochem Biophys Res Commun 263(2): 410-8.
Li, J. and S. Tong, et al. (1999). "Identification and expression of glycine decarboxylase (p120) as a duck hepatitis B virus pre-S envelope-binding protein." J Biol Chem 274(39): 27658-65.
Tong, S. and J. Li, et al. (1999). "Carboxypeptidase D is an avian hepatitis B virus receptor." J Virol 73(10): 8696-702.
Zu, P. J. and J. R. Wands (1999). "Specific inhibition of hepatitis B virus replication by sense RNA." Antisense Nucleic Acid Drug Dev 9(3): 241-52.
Zu, P. J. and Q. Yu, et al. (1999). "Combinatorial screening and intracellular antiviral activity of hairpin ribozymes directed against hepatitis B virus." J Virol 73(7): 5381-7.
Zu, P. J. and A. Skerra, et al. (1998). "Cloning, bacterial synthesis, and characterization of immunoglobulin variable regions of a monoclonal antibody specific for the hepatitis B virus X protein." Gene 221(1): 143-9.
Encke, J. and P. J. Zu, et al. (1998). "Genetic immunization generates cellular and humoral immune responses against the  nonstructural proteins of the hepatitis C virus in a murine model." J Immunol 161(9): 4917-23.
Encke, J. and P. J. Zu, et al. (1998). "Total chemical synthesis of the 3' untranslated region of the hepatitis C virus with long oligodeoxynucleotides." J Virol Methods 74(1): 117-21.
Zu, P. J. and S. Wieland, et al. (1998). "Antisense RNA complementary to hepatitis B virus specifically inhibits viral replication." Gastroenterology 115(3): 702-13.
Geissler, M. and R. Schirmbeck, et al. (1998). "Cytokine and hepatitis B virus DNA co-immunizations enhance cellular and humoral  immune responses to the middle but not to the large hepatitis B virus surface antigen in mice." Hepatology 28(1): 202-10.
Yasui, K. and T. Wakita, et al. (1998). "The native form and maturation process of hepatitis C virus core protein." J Virol 72(7): 6048-55.
Moradpour, D. and T. Wakita, et al. (1998). "Tightly regulated expression of the entire hepatitis C virus structural region in continuous human cell lines." Biochem Biophys Res Commun 246(3): 920-4.
Melegari, M. and P. P. Scaglioni, et al. (1998). "Cloning and characterization of a novel hepatitis B virus x binding protein that  inhibits viral replication." J Virol 72(3): 1737-43.
Melegari, M. and P. P. Scaglioni, et al. (1998). "Hepatitis B virus mutants associated with 3TC and famciclovir administration are  replication defective." Hepatology 27(2): 628-33.
Melegari, M. and P. P. Scaglioni, et al. (1997). "The small envelope protein is required for secretion of a naturally occurring hepatitis B virus mutant with pre-S1 deleted." J Virol 71(7): 5449-54.
Geissler, M. and K. Tokushige, et al. (1997). "Cellular and humoral immune response to hepatitis B virus structural proteins in  mice after DNA-based immunization." Gastroenterology 112(4): 1307-20.
Tokushige, K. and D. Moradpour, et al. (1997). "Comparison between cytomegalovirus promoter and elongation factor-1 alpha promoter-driven constructs in the establishment of cell lines expressing hepatitis C virus core protein." J Virol Methods 64(1): 73-80.
Geissler, M. and A. Gesien, et al. (1997). "Enhancement of cellular and humoral immune responses to hepatitis C virus core protein using DNA-based vaccines augmented with cytokine-expressing plasmids." J Immunol 158(3): 1231-7.
Scaglioni, P. P. and M. Melegari, et al. (1997). "Posttranscriptional regulation of hepatitis B virus replication by the precore protein." J Virol 71(1): 345-53.
Wands, J. R. and M. Geissler, et al. (1997). "Nucleic acid-based antiviral and gene therapy of chronic hepatitis B infection." J Gastroenterol Hepatol 12(9-10): S354-69.
Geissler, M. and A. Gesien, et al. (1997). "Inhibitory effects of chronic ethanol consumption on cellular immune responses to hepatitis C virus core protein are reversed by genetic immunizations augmented with cytokine-expressing plasmids." J Immunol 159(10): 5107-13.
Geissler, M. and A. Gesien, et al. (1997). "Chronic ethanol effects on cellular immune responses to hepatitis B virus envelope protein: an immunologic mechanism for induction of persistent viral infection in alcoholics." Hepatology 26(3): 764-70.
Heintges, T. and J. R. Wands (1997). "Hepatitis C virus: epidemiology and transmission." Hepatology 26(3): 521-6.
Scaglioni, P. P. and M. Melegari, et al. (1997). "Biologic properties of hepatitis B viral genomes with mutations in the precore promoter and precore open reading frame." Virology 233(2): 374-81.
Li, J. S. and S. P. Tong, et al. (1996). "Characterization of a 120-Kilodalton pre-S-binding protein as a candidate duck hepatitis B virus receptor." J Virol 70(9): 6029-35.
Moradpour, D. and C. Englert, et al. (1996). "Characterization of cell lines allowing tightly regulated expression of hepatitis C virus core protein." Virology 222(1): 51-63.
Scaglioni, P. P. and M. Melegari, et al. (1996). "Recent advances in the molecular biology of hepatitis B virus." Baillieres Clin Gastroenterol 10(2): 207-25.
Tokushige, K. and T. Wakita, et al. (1996). "Expression and immune response to hepatitis C virus core DNA-based vaccine constructs." Hepatology 24(1): 14-20.
Moradpour, D. and T. Wakita, et al. (1996). "Characterization of three novel monoclonal antibodies against hepatitis C virus core protein." J Med Virol 48(3): 234-41.
Tong, S. and J. Li, et al. (1995). "Interaction between duck hepatitis B virus and a 170-kilodalton cellular protein  is mediated through a neutralizing epitope of the pre-S region and occurs during  viral infection." J Virol 69(11): 7106-12.
Iwata, K. and T. Wakita, et al. (1995). "Interferon gamma production by peripheral blood lymphocytes to hepatitis C virus  core protein in chronic hepatitis C infection." Hepatology 22(4 Pt 1): 1057-64.
Moradpour, D. and J. R. Wands (1995). "Understanding hepatitis B virus infection." N Engl J Med 332(16): 1092-3.
Maia, M. and H. Takahashi, et al. (1995). "Development of a two-site immuno-PCR assay for hepatitis B surface antigen." J Virol Methods 52(3): 273-86.
Scaglioni, P. P. and M. Melegari, et al. (1994). "Characterization of hepatitis B virus core mutants that inhibit viral replication." Virology 205(1): 112-20.
Wakita, T. and J. R. Wands (1994). "Specific inhibition of hepatitis C virus expression by antisense oligodeoxynucleotides. In vitro model for selection of target sequence." J Biol Chem 269(19): 14205-10.
von Weizsacker, F. and H. E. Blum, et al. (1994). "Polymerase chain reaction analysis of hepatitis B virus DNA in formalin-fixed, paraffin-embedded liver biopsies from alcoholics using a simplified and standardized amplification protocol." J Hepatol 20(5): 646-9.
Melegari, M. and S. Bruno, et al. (1994). "Properties of hepatitis B virus pre-S1 deletion mutants." Virology 199(2): 292-300.
Liang, T. J. and H. J. Bodenheimer, et al. (1994). "Presence of hepatitis B and C viral genomes in US blood donors as detected by polymerase chain reaction amplification." J Med Virol 42(2): 151-7.
Liang, T. J. and W. J. Makdisi, et al. (1993). "Targeted transfection and expression of hepatitis B viral DNA in human hepatoma cells." J Clin Invest 91(3): 1241-6.
von Weizsacker, F. and H. E. Blum, et al. (1992). "Cleavage of hepatitis B virus RNA by three ribozymes transcribed from a single DNA template." Biochem Biophys Res Commun 189(2): 743-8.
Wands, J. R. and T. J. Liang, et al. (1992). "Molecular pathogenesis of liver disease during persistent hepatitis B virus infection." Semin Liver Dis 12(3): 252-64.
Blum, H. E. and Z. S. Zhang, et al. (1992). "Hepatitis B virus X protein is not central to the viral life cycle in vitro." J Virol 66(2): 1223-7.
Hasegawa, K. and J. K. Huang, et al. (1991). "Association of hepatitis B viral precore mutations with fulminant hepatitis B in  Japan." Virology 185(1): 460-3.
Wands, J. R. and H. E. Blum (1991). "Hepatitis B and C virus and alcohol-induced liver injury." Hepatology 14(4 Pt 1): 730-3.
Blum, H. E. and T. J. Liang, et al. (1991). "Persistence of hepatitis B viral DNA after serological recovery from hepatitis B  virus infection." Hepatology 14(1): 56-63.
Liang, T. J. and K. Hasegawa, et al. (1991). "A hepatitis B virus mutant associated with an epidemic of fulminant hepatitis." N Engl J Med 324(24): 1705-9.
Liang, T. J. and Y. Baruch, et al. (1991). "Hepatitis B virus infection in patients with idiopathic liver disease." Hepatology 13(6): 1044-51.
Blum, H. E. and E. Galun, et al. (1991). "Naturally occurring missense mutation in the polymerase gene terminating hepatitis B virus replication." J Virol 65(4): 1836-42.
Blum, H. E. and E. Galun, et al. (1991). "Inhibition of hepatitis B virus by antisense oligodeoxynucleotides." Lancet 337(8751): 1230.
Liang, T. J. and H. E. Blum, et al. (1990). "Characterization and biological properties of a hepatitis B virus isolated from a patient without hepatitis B virus serologic markers." Hepatology 12(2): 204-12.
Liang, T. J. and K. J. Isselbacher, et al. (1989). "Rapid identification of low level hepatitis B-related viral genome in serum." J Clin Invest 84(4): 1367-71.
Takahashi, H. and H. Kameda, et al. (1988). "Development of a second generation monoclonal immunoradiometric assay. Increased  sensitivity leads to enhanced detection of hepatitis B viral infection." J Immunol Methods 112(2): 191-200.
Pol, S. and V. Thiers, et al. (1987). "Monoclonal anti-HBs antibodies radioimmunoassay and serum HBV-DNA hybridization as diagnostic tools of HBV infection: relative prevalence among HBsAg-negative alcoholics, patients with chronic hepatitis or hepatocellular carcinomas and blood donors." Eur J Clin Invest 17(6): 515-21.
Shih, C. and K. Burke, et al. (1987). "Tight clustering of human hepatitis B virus integration sites in hepatomas near a triple-stranded region." J Virol 61(11): 3491-8.
Kew, M. C. and Y. Fujita, et al. (1986). "Comparison between polyclonal and first and second generation monoclonal radioimmunoassays in the detection of hepatitis B surface antigen in patients with hepatocellular carcinoma." Hepatology 6(4): 636-9.
Ben-Porath, E. and Y. K. Fujita, et al. (1986). "Hepatitis B monoclonal antibody testing." Prog Liver Dis 8: 347-66.
Fujita, Y. K. and K. Kamata, et al. (1986). "Detection of hepatitis B virus infection in hepatitis B surface antigen-negative  hemodialysis patients by monoclonal radioimmunoassays." Gastroenterology 91(6): 1357-63.
Wands, J. R. and Y. K. Fujita, et al. (1986). "Identification and transmission of hepatitis B virus-related variants." Proc Natl Acad Sci U S A 83(17): 6608-12.
Ben-Porath, E. and J. R. Wands, et al. (1985). "Structural analysis of hepatitis B surface antigen by monoclonal antibodies." J Clin Invest 76(4): 1338-47.
Ben-Porath, E. and J. R. Wands, et al. (1985). "Improved detection of hepatitis B surface antigen (HBsAg) in blood donors by monoclonal radioimmunoassay." Transfusion 25(1): 10-4.
Gazitt, Y. and S. Margel, et al. (1985). "Development of a novel C1q immunoadsorbent for removal of circulating immunecomplexes: quantitative isolation of hepatitis B virus surface antigen and  immunecomplexes." Immunol Lett 11(1): 1-8.
Wands, J. R. and M. A. Wong, et al. (1984). "Hepatitis B viral antigenic structure: signature analysis by monoclonal radioimmunoassays." Proc Natl Acad Sci U S A 81(7): 2237-41.
Ben-Porath, E. and J. R. Wands (1984). "Monoclonal antibodies as diagnostic probes in the etiology of hepatitis." Semin Liver Dis 4(1): 76-88.
Wands, J. R. (1983). "Non-A, non-B hepatitis." Hepatology 3(5): 764-6.
Marciniak, R. A. and J. R. Wands, et al. (1983). "Quantitative removal of hepatitis B viral antigens from serum by a monoclonal IgM coupled to a biocompatible solid-phase support." Proc Natl Acad Sci U S A 80(12): 3821-5.
Wands, J. R. and H. M. Lieberman, et al. (1982). "Detection and transmission in chimpanzees of hepatitis B virus-related agents formerly designated "non-A, non-B" hepatitis." Proc Natl Acad Sci U S A 79(23): 7552-6.
Shafritz, D. A. and H. M. Lieberman, et al. (1982). "Monoclonal radioimmunoassays for hepatitis B surface antigen: demonstration of hepatitis B virus DNA or related sequences in serum and viral epitopes in immune  complexes." Proc Natl Acad Sci U S A 79(18): 5675-9.
Shouval, D. and D. A. Shafritz, et al. (1982). "Immunotherapy in nude mice of human hepatoma using monoclonal antibodies against  hepatitis B virus." Nature 298(5874): 567-9.
Wands, J. R. and R. A. Marciniak, et al. (1982). "Demonstration of previously undetected hepatitis B viral determinants in an Australian Aboriginal population by monoclonal anti-hbs antibody radioimmunoassays." Lancet 1(8279): 977-80.
Wands, J. R. and R. R. Bruns, et al. (1982). "Monoclonal IgM radioimmunoassay for hepatitis B surface antigen: high binding activity in serum that is unreactive with conventional antibodies." Proc Natl Acad Sci U S A 79(4): 1277-81.
Shouval, D. and J. R. Wands, et al. (1982). "Selecting binding and complement-mediated lysis of human hepatoma cells (PLC/PRF/5) in culture by monoclonal antibodies to hepatitis B surface antigen." Proc Natl Acad Sci U S A 79(2): 650-4.
Hodgson, H. J. and J. R. Wands, et al. (1982). "Experimental murine hepatitis and inducible suppressor cell function." J Clin Lab Immunol 7(1): 45-9.
Popp, J. J. and T. J. Harrist, et al. (1981). "Cutaneous vasculitis associated with acute and chronic hepatitis." Arch Intern Med 141(5): 623-9.
Wands, J. R. and R. I. Carlson, et al. (1981). "Immunodiagnosis of hepatitis B with high-affinity IgM monoclonal antibodies." Proc Natl Acad Sci U S A 78(2): 1214-8.
Wands, J. R. and V. J. Zurawski (1981). "High affinity monoclonal antibodies to hepatitis B surface antigen (HBsAg) produced by somatic cell hybrids." Gastroenterology 80(2): 225-32.
Klingenstein, R. J. and J. R. Wands (1980). "Immunologic effector mechanisms in hepatitis B-negative chronic active hepatitis." Springer Semin Immunopathol 3(3): 317-29.
Popp, J. J. and J. L. Dienstag, et al. (1980). "Essential mixed cryoglobulinemia without evidence for hepatitis B virus infection." Ann Intern Med 92(3): 379-83.
Wands, J. R. (1979). "Viral hepatitis and its effect on pregnancy." Clin Obstet Gynecol 22(2): 301-11.
Dienstag, J. L. and A. R. Rhodes, et al. (1978). "Urticaria associated with acute viral hepatitis type B: studies of pathogenesis." Ann Intern Med 89(1): 34-40.
Hodgson, H. J. and J. R. Wands, et al. (1978). "Alteration in suppressor cell activity in chronic active hepatitis." Proc Natl Acad Sci U S A 75(3): 1549-53.
Dienstag, J. L. and J. R. Wands, et al. (1977). "Hepatitis B and essential mixed cryoglobulinemia." N Engl J Med 297(17): 946-7.
Carter, E. A. and J. R. Wands, et al. (1977). "Effect of acute murine hepatitis (MHV-1-59) on ethanol oxidation in vivo." Gastroenterology 73(2): 321-6.
Farivar, M. and J. R. Wands, et al. (1976). "Beneficial effect of insulin and glucagon in fulminant murine viral hepatitis." Lancet 1(7961): 696-7.
Farivar, M. and J. R. Wands, et al. (1976). "Effect of insulin and glucagon on fulminant murine hepatitis." N Engl J Med 295(27): 1517-9.
Farivar, M. and J. R. Wands, et al. (1976). "Cryoprotein complexes and peripheral neuropathy in a patient with chronic active  hepatitis." Gastroenterology 71(3): 490-3.
Wands, J. R. and E. Alpert, et al. (1975). "Arthritis associated with chronic active hepatitis: complement activation and characterization of circulating immune complexes." Gastroenterology 69(6): 1286-91.
Wands, J. R. (1975). "Letter: Subacute and chronic active hepatitis after withdrawal of chemotherapy." Lancet 2(7942): 979.
Wands, J. R. and E. Mann, et al. (1975). "The pathogenesis of arthritis associated with acute hepatitis-B surface antigen-positive hepatitis. Complement activation and characterization of circulating immune complexes." J Clin Invest 55(5): 930-6.
Wands, J. R. and J. L. Perrotto, et al. (1975). "Cell-mediated immunity in acute and chronic hepatitis." J Clin Invest 55(5): 921-9.
Wands, J. R. and C. M. Chura, et al. (1975). "Serial studies of hepatitis-associated antigen and antibody in patients receiving antitumor chemotherapy for myeloproliferative and lymphoproliferative disorders." Gastroenterology 68(1): 105-12.
Wands, J. R. and J. A. Walker, et al. (1974). "Hepatitis B in an oncology unit." N Engl J Med 291(26): 1371-5.
Levin, M. L. and W. C. Maddrey, et al. (1974). "Hepatitis B transmission by dentists." JAMA 228(9): 1139-40.
Mitch, W. E. and J. R. Wands, et al. (1974). "Hepatitis B transmission in a family." JAMA 227(9): 1043-4.
Wands, J. R. and D. C. Salyer, et al. (1973). "Fulminant hepatitis complicated by pancreatitis." Johns Hopkins Med J 133(3): 156-60.