Baruch S. Blumberg，费城——HBV相关实验室及人物介绍系列

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Baruch S. Blumberg，费城，美国——HBV相关实验室及人物介绍系列

Baruch S. Blumberg，澳抗-乙肝病毒发现者，因此获诺贝尔奖
Fox Chase Cancer Center, Philadelphia

Blumberg, B. S. (2006). "The curiosities of hepatitis B virus: prevention, sex ratio, and demography." Proc Am Thorac Soc 3(1): 14-20.
Block, T. M. and A. S. Mehta, et al. (2006). "Does rapid oligomerization of hepatitis B envelope proteins play a role in resistance to proteasome degradation and enhance chronicity?" DNA Cell Biol 25(3): 165-70.
Blumberg, B. S. (2002). "The discovery of the hepatitis B virus and the invention of the vaccine: a scientific memoir." J Gastroenterol Hepatol 17 Suppl: S502-3.
Blumberg, B. S. (2002). "Baruch Blumberg--hepatitis B and beyond. Interviewed by Pam Das." Lancet Infect Dis 2(12): 767-71.
Zitzmann, N. and A. S. Mehta, et al. (1999). "Imino sugars inhibit the formation and secretion of bovine viral diarrhea virus,  a pestivirus model of hepatitis C virus: implications for the development of broad spectrum anti-hepatitis virus agents." Proc Natl Acad Sci U S A 96(21): 11878-82.
Block, T. M. and X. Lu, et al. (1998). "Role of glycan processing in hepatitis B virus envelope protein trafficking." Adv Exp Med Biol 435: 207-16.
Blumberg, B. S. (1997). "Hepatitis B virus, the vaccine, and the control of primary cancer of the liver." Proc Natl Acad Sci U S A 94(14): 7121-5.
Lu, X. and A. Mehta, et al. (1997). "Aberrant trafficking of hepatitis B virus glycoproteins in cells in which N-glycan processing is inhibited." Proc Natl Acad Sci U S A 94(6): 2380-5.
Mehta, A. and X. Lu, et al. (1997). "Hepatitis B virus (HBV) envelope glycoproteins vary drastically in their sensitivity to glycan processing: evidence that alteration of a single N-linked glycosylation site can regulate HBV secretion." Proc Natl Acad Sci U S A 94(5): 1822-7.
Payne, R. J. and M. A. Nowak, et al. (1996). "The dynamics of hepatitis B virus infection." Proc Natl Acad Sci U S A 93(13): 6542-6.
Feitelson, M. A. and L. X. Duan, et al. (1995). "Precore and X region mutants in hepatitis B virus infections among renal dialysis patients." J Viral Hepat 2(1): 19-31.
Feitelson, M. A. and L. X. Duan, et al. (1995). "X region deletion variants of hepatitis B virus in surface antigen-negative infections and non-A, non-B hepatitis." J Infect Dis 172(3): 713-22.
Feitelson, M. A. and L. X. Duan, et al. (1995). "X region deletion mutants associated with surface antigen-positive hepatitis B virus infections." Gastroenterology 108(6): 1810-9.
Blumberg, B. S. (1995). "Complex interactions of hepatitis B virus with its host and environment. The Croonian Lecture 1994." J R Coll Physicians Lond 29(1): 31-40.
Blumberg, B. S. (1994). "Complexity and the hepatitis viruses." Gut 35(12): 1770-1.
Payne, R. J. and M. A. Nowak, et al. (1994). "A cellular model to explain the pathogenesis of infection by the hepatitis B virus." Math Biosci 123(1): 25-58.
McLean, A. R. and B. S. Blumberg (1994). "Modelling the impact of mass vaccination against hepatitis B. I. Model formulation and parameter estimation." Proc Biol Sci 256(1345): 7-15.
Block, T. M. and X. Lu, et al. (1994). "Secretion of human hepatitis B virus is inhibited by the imino sugar N-butyldeoxynojirimycin." Proc Natl Acad Sci U S A 91(6): 2235-9.
Feitelson, M. and L. Lega, et al. (1994). "Pathogenesis of posttransfusion viral hepatitis in children with beta-thalassemia." Hepatology 19(3): 558-68.
Payne, R. J. and M. A. Nowak, et al. (1992). "Analysis of a cellular model to account for the natural history of infection by the hepatitis B virus and its role in the development of primary hepatocellular carcinoma." J Theor Biol 159(2): 215-40.
Lega, L. and A. Vierucci, et al. (1992). "Hepatitis B x antigen and polymerase antibodies in the serum of hepatitis B carriers with or without hepatitis delta virus infection. Effects of interferon treatment." J Hepatol 14(2-3): 286-93.
Horiike, N. and B. S. Blumberg, et al. (1991). "Characteristics of hepatitis B X antigen, antibodies to X antigen, and antibodies to the viral polymerase during hepatitis B virus infection." J Infect Dis 164(6): 1104-12.
Blumberg, B. S. and I. Millman, et al. (1990). "Hepatitis B virus and primary hepatocellular carcinoma: treatment of HBV carriers with Phyllanthus amarus." Vaccine 8 Suppl: S86-92.
Blumberg, B. S. (1989). "Feasibility of controlling or eradicating the hepatitis B virus." Am J Med 87(3A): 2S-4S.
Venkateswaran, P. S. and I. Millman, et al. (1989). "Interaction of fucoidan from Pelvetia fastigiata with surface antigens of hepatitis B and woodchuck hepatitis viruses." Planta Med 55(3): 265-70.
Blumberg, B. S. and I. Millman, et al. (1989). "Hepatitis B virus and hepatocellular carcinoma--treatment of HBV carriers with Phyllanthus amarus." Cancer Detect Prev 14(2): 195-201.
Blumberg, B. S. (1988). "Hepatitis B virus and the carrier problem." Soc Res (New York) 55(3): 401-12.
Thyagarajan, S. P. and S. Subramanian, et al. (1988). "Effect of Phyllanthus amarus on chronic carriers of hepatitis B virus." Lancet 2(8614): 764-6.
Chahnazarian, A. and B. S. Blumberg, et al. (1988). "Hepatitis B and the sex ratio at birth: a comparative analysis of four populations." J Biosoc Sci 20(3): 357-70.
Feitelson, M. A. and I. Millman, et al. (1988). "Presence of antibodies to the polymerase gene product(s) of hepatitis B and woodchuck hepatitis virus in natural and experimental infections." J Med Virol 24(2): 121-36.
Kim, C. Y. and S. K. Bae, et al. (1985). "Prevalence of HBeAg and anti-HBe in chronic active hepatitis, cirrhosis and primary hepatocellular carcinoma in Korea." Hepatology 5(1): 54-6.
Vierucci, A. and M. de Martino, et al. (1984). "Raised IgE levels in beta-thalassaemia: correlation with splenectomy and hepatitis B virus infection." Clin Exp Immunol 58(1): 199-205.
Langendorfer, A. and W. Davenport, et al. (1984). "Sex-related differences in transmission of hepatitis B infection in a Melanesian  population." Am J Phys Anthropol 64(3): 243-54.
Franklin, S. G. and I. Millman, et al. (1984). "Hepatitis B surface antigen and polymerized albumin binding activity in sheep serum." Proc Natl Acad Sci U S A 81(2): 564-7.
Blumberg, B. S. (1984). "Hepatitis B virus and the control of hepatocellular carcinoma." IARC Sci Publ(63): 243-61.
Stevens, R. G. and S. Kuvibidila, et al. (1983). "Iron-binding proteins, hepatitis B virus, and mortality in the Solomon Islands." Am J Epidemiol 118(4): 550-61.
Vierucci, A. and M. De Martino, et al. (1983). "A mechanism for liver cell injury in viral hepatitis: effects of hepatitis B virus on neutrophil function in vitro and in children with chronic active hepatitis." Pediatr Res 17(10): 814-20.
Lustbader, E. D. and H. W. Hann, et al. (1983). "Serum ferritin as a predictor of host response to hepatitis B virus infection." Science 220(4595): 423-5.
Blumberg, B. S. (1983). "Hepatitis B virus and the pathogenesis and prevention of cancer of the liver." Prog Clin Biol Res 132D: 77-8.
Blumberg, B. S. and W. T. London (1982). "Primary hepatocellular carcinoma and hepatitis B virus." Curr Probl Cancer 6(12): 1-23.
Blumberg, B. S. (1982). "[Hepatitis B and the prevention of hepatocellular carcinoma]." Nouv Presse Med 11(12): 903-5.
Drew, J. and W. T. London, et al. (1982). "Hepatitis B virus and sex ratio on Kar Kar Island." Hum Biol 54(1): 123-35.
Blumberg, B. S. (1982). "Part 2: Hepatitis B infection and human behavior." Med Anthropol 6(1): 11-9.
Blumberg, B. S. and W. T. London (1982). "Hepatitis B virus: pathogenesis and prevention of primary cancer of the liver." Cancer 50(11 Suppl): 2657-65.
Hann, H. W. and C. Y. Kim, et al. (1982). "Hepatitis B virus and primary hepatocellular carcinoma: family studies in Korea." Int J Cancer 30(1): 47-51.
Blumberg, B. S. (1981). "Viruses similar to hepatitis B virus (Icrons)." Hum Pathol 12(12): 1107-13.
Dickie, E. R. and W. T. London, et al. (1981). "Hepatitis B virus infection in infants of anti-HBs (+) mothers." Lancet 1(8227): 1000.
Blumberg, B. S. and W. T. London (1981). "Hepatitis B virus and the prevention of primary hepatocellular carcinoma." N Engl J Med 304(13): 782-4.
Blumberg, B. S. and E. D. Lustbader, et al. (1981). "Changes in serum iron levels due to infection with hepatitis B virus." Proc Natl Acad Sci U S A 78(5): 3222-4.
Froment, A. and B. Larouze, et al. (1981). "Hepatitis B infection and the prevention of primary hepatocellular carcinoma: studies in Senegal." Prog Med Virol 27: 133-6.
Yarrish, R. L. and B. G. Werner, et al. (1980). "Association of hepatitis B virus infection with hepatocellular carcinoma in American patients." Int J Cancer 26(6): 711-5.
Blumberg, B. S. (1980). "The hepatitis B virus." Public Health Rep 95(5): 427-35.
Blumberg, B. S. (1979). "Sex differences in response to hepatitis B virus. I. History." Arthritis Rheum 22(11): 1261-6.
Felton, C. and E. D. Lustbader, et al. (1979). "Serum iron levels and response to hepatitis B virus." Proc Natl Acad Sci U S A 76(5): 2438-41.
Werner, B. G. and B. S. Blumberg (1978). "e Antigen in hepatitis B virus infected dialysis patients: assessment of its prognostic value." Ann Intern Med 89(3): 310-4.
Drew, J. S. and W. T. London, et al. (1978). "Hepatitis B virus and sex ratio of offspring." Science 201(4357): 687-92.
Millman, I. and B. S. Blumberg (1978). "[Prospects for vaccination against hepatitis B]." Rev Prat 35(25): 1943-51.
London, W. T. and J. S. Drew, et al. (1978). "Hepatitis B infection and kidney-graft survival." N Engl J Med 298(6): 342.
Drew, J. S. and W. T. London, et al. (1978). "Cross reactivity between hepatitis B surface antigen and a male-associated antigen." Birth Defects Orig Artic Ser 14(6A): 91-101.
Wills, W. and B. Larouze, et al. (1977). "Hepatitis-B virus in bedbugs (Cimex hemipterus) from Senegal." Lancet 2(8031): 217-9.
London, W. T. and J. S. Drew, et al. (1977). "Host responses to hepatitis B infection in patients in a chronic hemodialysis unit." Kidney Int 12(1): 51-8.
Blumberg, B. S. (1977). "Australia antigen and the biology of hepatitis B." Science 197(4298): 17-25.
Blumberg, B. S. (1977). "Non-A, non-B hepatitis." Ann Intern Med 87(1): 111-3.
London, W. T. and J. S. Drew, et al. (1977). "Association of graft survival with host response to hepatitis B infection in patients with kidney transplants." N Engl J Med 296(5): 241-4.
Vierucci, A. and W. T. London, et al. (1977). "Neutrophil function in children who are carriers of hepatitis-B surface antigen." Lancet 1(8004): 157-60.
Hesser, J. E. and B. S. Blumberg, et al. (1976). "Hepatitis B surface antigen, fertility and sex ratio: implications for health planning." Hum Biol 48(1): 73-81.
Wills, W. and G. Saimot, et al. (1976). "Hepatitis B surface antigen (Australia antigen) in mosquitoes collected in Senegal, West Africa." Am J Trop Med Hyg 25(1): 186-90.
Snydman, D. R. and J. A. Bryan, et al. (1976). "Transmission of hepatitis B associated with hemodialysis: role of malfunction (blood leaks) in dialysis machines." J Infect Dis 134(6): 562-70.
Blumberg, B. S. and B. Larouze, et al. (1976). "[The relation of infection with the hepatitis B-agent to primary hepatic carcinoma (author's transl)]." Leber Magen Darm 6(6): 309-15.
Blumberg, B. S. (1976). "Bioethical questions related to hepatitis B antigen." Am J Clin Pathol 65(5 Suppl): 848-53.
Lustbader, E. D. and W. T. London, et al. (1976). "Study design for a hepatitis B vaccine trial." Proc Natl Acad Sci U S A 73(3): 955-9.
Hesser, J. E. and J. Economidou, et al. (1975). "Hepatitis B surface antigen (Australia antigen) in parents and sex ratio of offspring in a Greek population." Hum Biol 47(4): 415-25.
Blumberg, B. S. and B. Larouze, et al. (1975). "The relation of infection with the hepatitis B agent to primary hepatic carcinoma." Am J Pathol 81(3): 669-82.
Maupas, P. and B. Werner, et al. (1975). "Antibody to hepatitis-B core antigen in patients with primary hepatic carcinoma." Lancet 2(7923): 9-11.
Blumberg, B. S. and J. E. Hesser, et al. (1975). "The variety of responses within a community to infection with Australia (hepatitis B) antigen." Dev Biol Stand 30: 270-83.
Senior, J. R. and A. I. Sutnick, et al. (1974). "Reduction of post-transfusion hepatitis by exclusion of Australia antigen from donor blood in an urban public hospital." Am J Med Sci 267(3): 171-7.
Blumberg, B. S. and W. T. London, et al. (1974). "Hepatitis carriers among soldiers who have returned from Vietnam. Australia antigen studies." Transfusion 14(1): 63-6.
Metselaar, D. and B. S. Blumberg, et al. (1973). "Hepatitis-B antigen in colony mosquitoes." Lancet 2(7832): 758-9.
Chiurco, A. A. and A. I. Sutnick, et al. (1973). "Antibody to Australia antigen in an outbreak of hepatitis on an Indian reservation." Res Commun Chem Pathol Pharmacol 6(1): 273-92.
Huang, S. N. and I. Millman, et al. (1972). "Virus-like particles in Australia antigen-associated hepatitis. An immunoelectron microscopic study of human liver." Am J Pathol 67(3): 453-70.
Sutnick, A. I. and W. T. London, et al. (1972). "Australia antigen, posttransfusion hepatitis, and the chronic carrier state." Am J Dis Child 123(4): 392-400.
London, W. T. and A. I. Sutnick, et al. (1972). "Australia antigen and hepatitis: recent observations on the serum protein polymorphism, infectious agent hypotheses." Can Med Assoc J 106: Suppl:480-5.
Sutnick, A. I. and W. T. London, et al. (1972). "Persistent anicteric hepatitis with Australia antigen in patients with Down's syndrome." Am J Clin Pathol 57(1): 2-12.
Sutnick, A. I. and I. Millman, et al. (1972). "The role of Australia antigen in viral hepatitis and other diseases." Annu Rev Med 23: 161-76.
Millman, I. and S. S. Agarwal, et al. (1971). "Lymphocyte transformation and hepatitis. II. Lack of direct in vitro inhibition by purified Australia antigen." Proc Soc Exp Biol Med 138(1): 198-203.
Agarwal, S. S. and B. S. Blumberg, et al. (1971). "Lymphocyte transformation and hepatitis. I. Impairment of thymidine incorporation and DNA polymerase activity." Proc Soc Exp Biol Med 137(4): 1498-502.
Blumberg, B. S. and A. I. Sutnick, et al. (1971). "Australia antigen and hepatitis: a comprehensive review." CRC Crit Rev Clin Lab Sci 2(3): 473-528.
Sutnick, A. I. and W. T. London, et al. (1971). "Ergasteric hepatitis: endemic hepatitis associated with Australia antigen in a research laboratory." Ann Intern Med 75(1): 35-40.
Sutnick, A. I. and J. J. Cerda, et al. (1971). "Australia antigen and viral hepatitis in drug abusers." Arch Intern Med 127(5): 939-41.
Blumberg, B. S. and A. I. Sutnick, et al. (1970). "Australia antigen and hepatitis." N Engl J Med 283(7): 349-54.
Sutnick, A. I. and W. T. London, et al. (1970). "Australia antigen (a hepatitis-associated antigen) in leukemia." J Natl Cancer Inst 44(6): 1241-9.
Millman, I. and L. A. Loeb, et al. (1970). "Australia antigen (a hepatitis-associated antigen): purification and physical properties." J Exp Med 131(6): 1190-9.
Sutnick, A. I. and W. T. London, et al. (1970). "Viral hepatitis. Revised concepts as a result of the study of Australia antigen." Med Clin North Am 54(3): 805-17.
Blumberg, B. S. and L. Melartin (1970). "Australia antigen and hepatitis. Studies in asymptomatic people and lepromatous leprosy patient." Arch Intern Med 125(2): 287-92.
Blumberg, B. S. (1970). "Adaptation to infectious disease. Australia antigen and hepatitis." Am J Phys Anthropol 32: 305-8.
Blumberg, B. S. and W. T. London, et al. (1970). "Australia antigen, hepatitis and susceptibility to leukemia." Bibl Haematol(36): 659-77.
Sutnick, A. I. and F. A. Oski, et al. (1970). "Erythrocyte glucose-6 phosphate dehydrogenase (G6PD) and Australia antigen hepatitis in Down's syndrome." Res Commun Chem Pathol Pharmacol 1(1): 3-8.
Blumberg, B. S. and A. I. Sutnick, et al. (1970). "Australia antigen as a hepatitis virus. Variation in host response." Am J Med 48(1): 1-8.
Smith, J. B. and B. S. Blumberg (1969). "Viral hepatitis, postnecrotic cirrhosis, and hepatocellular carcinoma." Lancet 2(7627): 953.
London, W. T. and M. Di Figlia, et al. (1969). "An epidemic of hepatitis in a chronic-hemodialysis unit. Australia antigen and differences in host response." N Engl J Med 281(11): 571-8.
Millman, I. and V. Zavatone, et al. (1969). "Australia antigen detected in the nuclei of liver cells of patients with viral hepatitis by the fluorescent antibody technic." Nature 222(5189): 181-4.
Blumberg, B. S. and J. S. Friedlaender, et al. (1969). "Hepatitis and Australia antigen: autosomal recessive inheritance of susceptibility to infection in humans." Proc Natl Acad Sci U S A 62(4): 1108-15.
Blumberg, B. S. and A. I. Sutnick, et al. (1969). "Australia antigen and hepatitis." JAMA 207(10): 1895-6.
Sutnick, A. I. and W. T. London, et al. (1969). "Australia antigen and the quest for a hepatitis virus." Am J Dig Dis 14(3): 189-94.
Levene, C. and B. S. Blumberg (1969). "Additional specificities of Australia antigen and the possible identification of  hepatitis carriers." Nature 221(5176): 195-6.
London, W. T. and A. I. Sutnick, et al. (1969). "Australia antigen and acute viral hepatitis." Ann Intern Med 70(1): 55-9.
Blumberg, B. S. and A. I. Sutnick, et al. (1968). "Hepatitis and leukemia: their relation to Australia antigen." Bull N Y Acad Med 44(12): 1566-86.
Sutnick, A. I. and W. T. London, et al. (1968). "Anicteric hepatitis associated with Australia antigen. Occurrence in patients with Down's syndrome." JAMA 205(10): 670-4.
Bayer, M. E. and B. S. Blumberg, et al. (1968). "Particles associated with Australia antigen in the sera of patients with leukaemia, Down's Syndrome and hepatitis." Nature 218(5146): 1057-9.
Blumberg, B. S. and B. J. Gerstley, et al. (1967). "A serum antigen (Australia antigen) in Down's syndrome, leukemia, and hepatitis." Ann Intern Med 66(5): 924-31.