[转移帖]Michael Bouchard Drexel University College of Medicine-HBV人物介绍系列

hantavirus

原帖由brent1121 发表于 2010-9-5 14:53 ：

http://www.drexelmed.edu/Home/Ab ... ichaelBouchard.aspx

Michael Bouchard 毕业于哥伦比亚大学，他以前跟的导师R. Schneide也是搞HBV的大牛，但是他导师现在貌似很少HBV的文章发表了，倒是Michael Bouchard继承了导师的研究，一直奋斗在HBX蛋白的相关研究领域之中，每年都有文章在JOV杂志上发表（JOV影响因子不算很高，五点多，但算是病毒学研究的顶级杂志之一了）。Michael Bouchard现在已是副教授，九七年毕业，毕业十年就当上副教授，确实很牛逼。现在虽然还没能和一流的病毒学家媲美，但是假以时日，相信他一定会越来越牛逼的。


RESEARCH INTERESTS: Liver Cancer, hepatocyte transformation, calcium signaling, apoptosis, cell proliferation, alcohol, novel liver models

SELECTED PUBLICATIONS:

T. Gearhart and M. Bouchard. (2010) The hepatitis B virus X protein modulates hepatocyte proliferation pathways to stimulate viral replication. J. Virol. 84: 2675-2686.

EA Vitol, Z. Orynbayeva, M. Bouchard, J. Azizkhan-Clifford, G. Friedman, and Y. Gogotsi. (2009) In situ intracellular spectroscopy with surface enhanced raman spectroscopy (SERS)-enabled nanopipettes. ACS Nano. 3; 3529-3536.

A. Clippinger, T. Gearhart and M. Bouchard. (2009) The hepatitis B virus X protein modulates apoptosis in primary rat hepatocytes by regulating both NF-kB and the mitochondrial permeability transition pore.
J. Virol. 83: 4718-4713.

A. Clippinger and M.Bouchard (2008). Hepatitis B virus HBx protein localizes to mitochondria in primary rat hepatocytes and modulates mitochondrial membrane potential. J Virol. 82: 6798-6811.

T. Sodunke, M. Bouchard and H. Noh (2008) Microfluidic platform for hepatitis B viral replication study. Biomed Microdevices. 10: 393-402

M. Bouchard and S. McClain. (2007) Regulation of cellular signal transduction cascades by the hepatitis B virus X protein. In: The pleiotropic functions of the viral protein HBx in Hepatitis B virus infection and the development of liver cancer. J. Kobarg (Ed). Research Signpost 37/661: 241-264.

S. McClain, A. Clippinger, R. Lizzano and M. Bouchard (2007). HBV replication is associated with an HBx-dependent mitochondrial-regulated increase in intracellular calcium levels. J. Virol. 81: 12061-12065.

M. Bouchard, L-H. Wang, and R. Schneider. (2006) Activation of focal adhesion kinase by hepatitis B virus HBx protein:  multiple functions in viral replication. J. Virol. 80: 4406-4414

M. Bouchard, and R. Schneider. (2004) The enigmatic X gene of Hepatitis B virus. J. Virol.  78: 12725-12734

M. Bouchard, R. Puro, L-H. Wang, and R. Schneider. (2003) Activation and inhibition of cellular calcium and tyrosine kinase signaling pathways identify targets of the HBx protein involved in HBV replication. J Virol. 77: 7713-7719

M. Bouchard, L-H. Wang, and R. Schneider. (2001) Calcium signaling by HBx protein in Hepatitis B virus DNA replication. Science 294: 2376-2378

M. Bouchard, S. Giannakopoulos, E. Wang, N. Tanese, and R. Schneider. (2001) The hepatitis B virus X protein activates the cyclin A promoter in a Src-dependent manner. J. Virol. 75: 4247-4257.

N. Klein, M. Bouchard, L-H Wang, C. Korbarg, and R. Schneider.  (1999) Src kinases involved in hepatitis B virus replication. EMBO J. 18: 5019-5027.