CAR-T 细胞：肿瘤连环杀手

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CAR-T cells are serial killers.

Chimeric antigen receptor (CAR) T cells have enjoyed unprecedented clinical success against haematological malignancies in recent years. However, several aspects of CAR T cell biology remain unknown. We recently compared CAR and T cell receptor (TCR)-based killing in the same effector cell and showed that CAR T cells can not only efficiently kill single tumor targets, they can also kill multiple tumor targets in a sequential manner. Single and serial killing events were not sustained long term due to CAR down-regulation after 20 hours.

CAR-T 细胞：肿瘤连环杀手

近年来，嵌合抗原受体（CAR）修饰的的T细胞对血液系统恶性肿瘤有着前所未有的临床成功。然而，CAR-T细胞生物学有几个方面仍然是未知的。我们最近比较CAR和以T细胞受体（TCR）为基础的杀伤能力在相同效应细胞中的差别，发现CAR-T细胞不仅能够有效杀死单个肿瘤靶点，也能以一定的顺序杀死多个肿瘤靶点。单一和连续的杀伤能力没有持续性，由于20小时后CAR的数量降低。

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