【转移帖】IL-21 Is Required to Control Chronic Viral Infection

hantavirus

原帖由yaoming发表于 2009-9-28 01:26 ：

[最新进展] IL-21 Is Required to Control Chronic Viral Infection
本帖最后由 yaoming 于 2009-9-28 01:31 编辑

这是发表在今年的Science 324, 1569 (2009)上的一篇文章，结果提示，IL-21主要由CD4+T cell 分泌，在CD4+T cell 辅助CD8+ T cell 抗病毒免疫过程中发挥重要作用，但是其具体的作用机理仍不清楚，有待进一步研究。

CD4+ and CD8+ T cell functions are rapidly aborted during chronic infection, preventing viral clearance. CD4+ T cell help is required throughout chronic infection so as to sustain CD8+ T cell responses; however, the necessary factor(s) provided by CD4+ T cells are currently unknown. Using a mouse model of chronic viral infection, we demonstrated that interleukin-21 (IL-21) is an essential component of CD4+ T cell help. In the absence of IL-21 signaling, despite elevated CD4+ T cell responses, CD8+ T cell responses are severely impaired. CD8+ T cells directly require IL-21 to avoid deletion, maintain immunity, and resolve persistent infection. Thus, IL-21 specifically sustains CD8+ T cell effector activity and provides a mechanism of CD4+ T cell help during chronic viral infection.  

science 前后共发表了三篇类似的文章:

1. IL-21 Is Required to Control Chronic Viral Infection  Heidi Elsaesser, Karsten Sauer, and David G. Brooks
Science 19 June 2009 324: 1569-1572; published online 7 May 2009 [DOI: 10.1126/science.1174182] (in Reports)

2. A Vital Role for Interleukin-21 in the Control of a Chronic Viral Infection  John S. Yi, Ming Du, and Allan J. Zajac Science 19 June 2009 324: 1572-1576; published online 14 May 2009 [DOI: 10.1126/science.1175194] (in Reports)

3. IL-21R on T Cells Is Critical for Sustained Functionality and Control of Chronic Viral Infection
Anja Fröhlich, Jan Kisielow, Iwana Schmitz, Stefan Freigang, Abdijapar T. Shamshiev, Jacqueline Weber, Benjamin J. Marsland, Annette Oxenius, and Manfred Kopf Science 19 June 2009 324: 1576-1580; published online 28 May 2009 [DOI: 10.1126/science.1172815] (in Reports)

有需要上述文章的，留下EMAIL，我可以发给你们！附件添加不进去。