设为首页收藏本站

中国病毒学论坛|我们一直在坚持!

 找回密码
 立即注册

QQ登录

只需一步,快速开始

搜索
热搜: 活动 交友 discuz
查看: 1252|回复: 0
打印 上一主题 下一主题

Rotavirus reassortant induced murine model of liver fibrosis

[复制链接]

2204

帖子

2852

学分

3万

金币

管理员

Rank: 9Rank: 9Rank: 9Rank: 9

积分
2852
跳转到指定楼层
楼主
发表于 2019-8-26 07:52:39 | 只看该作者 回帖奖励 |倒序浏览 |阅读模式
Abstract
Biliary atresia (BA) is a devastating neonatal cholangiopathy that progresses to fibrosis and end‐stage liver disease by two years of age. Portoenterostomy may re‐establish biliary drainage but, despite drainage, virtually all afflicted patients develop fibrosis and progress to end stage liver disease requiring liver transplantation for survival. In the murine model of BA, Rhesus rotavirus (RRV) infection of newborn pups results in a cholangiopathy paralleling human BA and has been used to study mechanistic aspects of the disease. Unfortunately, nearly all RRV‐infected pups succumb by day of life 14. Thus in this study we generated a novel RRV‐TUCH rotavirus reassortant (designated as TR(VP2,VP4)) that when injected into newborn mice causes an obstructive jaundice phenotype with lower mortality rates. Of the mice that survived, 63% developed Ishak stage 3‐5 fibrosis with histopathological signs of inflammation/fibrosis and bile‐duct obstruction. This novel model of rotavirus‐induced neonatal fibrosis will provide an opportunity to study disease pathogenesis and has potential to be used in preclinical studies with an objective to identify novel therapeutic targets that may alter the course of BA.

https://aasldpubs.onlinelibrary. ... s/10.1002/hep.30907
分享到:  QQ好友和群QQ好友和群 QQ空间QQ空间 腾讯微博腾讯微博 腾讯朋友腾讯朋友
收藏收藏 分享分享 支持支持 反对反对
您需要登录后才可以回帖 登录 | 立即注册

本版积分规则

QQ|论坛App下载|Archiver|小黑屋|中国病毒学论坛    

GMT+8, 2024-4-25 13:14 , Processed in 0.069250 second(s), 28 queries .

Powered by Discuz! X3.2

© 2001-2013 Comsenz Inc.

快速回复 返回顶部 返回列表