请问寨卡病毒未来研究的热点是什么？
请大家讨论，比较靠谱一点的:D 致病机制、治疗药物、预防疫苗 Notice of NICHD, NINDS, NIDCR and NIAID's Interest to Prioritize Zika Virus (ZIKV) Research AreasPurpose
NICHD, NINDS, NIDCR and NIAID are issuing this Notice tohighlight interest in research on Zika virus (ZIKV) as it relates to themother-infant dyad and sequelae of infection.
Areas of high priority include, but are not limited to, thefollowing:
Demonstrate causative role of infection inpregnancy with Zika virus (ZIKV) in the etiology of fetal microcephaly
Basic research to understand the ZIKV infectionpathogenesis and transmission to the fetus, whether in-utero, postpartum, orbreastfeeding
Population-based studies to characterize theepidemiology of ZIKV infection in the mother-infant dyad
Clinical studies to improve the understanding ofthe mechanisms and risks of maternal to child transmission of ZIKV
Determine the timeline for when and how womentransmit ZIKV to the fetus
Strategies to prevent transmission of ZIKV tothe fetus after infection in the mother
Studies to determine the optimal screening forand management of ZIKV infection in pregnant women and in exposed fetuses
Studies to understand the mechanisms by whichZIKV affects the developing nervous system and other organ systems
Research to develop lab-based or point-of-carediagnosis for ZIKV using saliva as a biofluid
Studies to characterize the outcome of viralinfection on craniofacial skeletal and dental phenotype with or withoutmicrocephaly
Studies to understand pregnancy outcomes inwomen infected with ZIKV
Studies to identify sequelae in infants infectedwith ZIKV as well as potential sequelae in exposed but uninfected infants
Strategies to identify neurologic and othermanifestations in infants with and without microcephaly such as developmentaldelays and other neurologic or physical disorders
Studies to assess and characterize the naturalhistory and long-term neurodevelopmental consequences of ZIKV infection inchildren
Strategies to identify effective treatments forexposed infants with and without microcephaly as they develop intochildhood.Such strategies must takeinto account cultural acceptance and resources
Investigations of mediating and moderatingfactors affecting variability in neurodevelopmental, behavioral, andsocio-emotional impact of ZIKV exposure on infants prenatally and postnatally
Develop novel, simple, feasible andcost-effective testing methods and/or strategies for infection screening duringpregnancy
Develop novel, simple, rapid, feasible and costeffective testing methods and/or strategies for infection screening in theinfant
Research to develop lab-based or point-of-carediagnosis for ZIKV using saliva as a biofluid
Develop culturally sensitive strategies toincrease knowledge about the relative efficacy of contraceptive methods, anduse that knowledge to plan for pregnancy
Strategies to integrate the discussion of riskof ZIKV infection into contraceptive counseling and pre-pregnancy and prenatalcare at medical facilities in ZIKV endemic areas
Determine long-term implications of ZIKVinfection in non-pregnant women and men including impact on fertility andsubsequent pregnancy
Studies to ascertain if ZIKV is present inreproductive fluids such as semen, cervical mucus, vaginal secretions and/orfollicular fluid; persistence of ZIKV in these fluids; and the mechanisms bywhich ZIKV enters the reproductive tract
Studies on effects of ZIKV on in vitrofertilization
Studies on whether ZIKV can be transmitted bydirect sexual contact or artificial reproductive technology procedures
Once causality is demonstrated, studies onvaccine development in pregnant women and children
Once causality is demonstrated, development ofmethods to explain risk of ZIKV infection and risk of harm to the fetus topregnant women and women who are planning to become pregnant
Possible funding opportunities that can be used to pursuethese research activities include:
PA-16-031,Advancing Understanding, prevention, and management of Infections Transmittedfrom Women to their Infants (R21)
PA-16-032,Advancing Understanding, prevention, and management of Infections Transmittedfrom Women to their Infants (R01)
NOT-TW-16-001,Parallel Funding Initiative for Collaborative Research Between Investigators inthe USA and in the State of Sao Paulo, Brazil
PAR-16-061,Natural History of Disorders Identifiable by Screening of Newborns (R01)
PAR-14-331,Global Brain and Nervous System Disorders Research Across the Lifespan (R21)
PAR-14-332,Global Brain and Nervous System Disorders Research Across the Lifespan (R01)
PAR-15-192 ,Immune System Plasticity in the Pathogenesis and Treatment of Complex Dental,Oral, and Craniofacial Diseases (R01)
PAR-15-193,Immune System Plasticity in the Pathogenesis and Treatment of Complex Dental,Oral, and Craniofacial Diseases (R21)
PA-13-302,R01 Research Project Grant
PA-13-303,R21 Exploratory/Developmental Research Grant
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