请问寨卡病毒未来研究的热点是什么？

zikavirus

请大家讨论，比较靠谱一点的

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致病机制、治疗药物、预防疫苗

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Notice of NICHD, NINDS, NIDCR and NIAID's Interest to Prioritize Zika Virus (ZIKV) Research Areas

Purpose
NICHD, NINDS, NIDCR and NIAID are issuing this Notice to  highlight interest in research on Zika virus (ZIKV) as it relates to the  mother-infant dyad and sequelae of infection.  
Areas of high priority include, but are not limited to, the  following:
Demonstrate causative role of infection in  pregnancy with Zika virus (ZIKV) in the etiology of fetal microcephaly
Basic research to understand the ZIKV infection  pathogenesis and transmission to the fetus, whether in-utero, postpartum, or  breastfeeding
Population-based studies to characterize the  epidemiology of ZIKV infection in the mother-infant dyad
Clinical studies to improve the understanding of  the mechanisms and risks of maternal to child transmission of ZIKV
Determine the timeline for when and how women  transmit ZIKV to the fetus
Strategies to prevent transmission of ZIKV to  the fetus after infection in the mother
Studies to determine the optimal screening for  and management of ZIKV infection in pregnant women and in exposed fetuses
Studies to understand the mechanisms by which  ZIKV affects the developing nervous system and other organ systems
Research to develop lab-based or point-of-care  diagnosis for ZIKV using saliva as a biofluid
Studies to characterize the outcome of viral  infection on craniofacial skeletal and dental phenotype with or without  microcephaly
Studies to understand pregnancy outcomes in  women infected with ZIKV
Studies to identify sequelae in infants infected  with ZIKV as well as potential sequelae in exposed but uninfected infants
Strategies to identify neurologic and other  manifestations in infants with and without microcephaly such as developmental  delays and other neurologic or physical disorders
Studies to assess and characterize the natural  history and long-term neurodevelopmental consequences of ZIKV infection in  children
Strategies to identify effective treatments for  exposed infants with and without microcephaly as they develop into  childhood.  Such strategies must take  into account cultural acceptance and resources
Investigations of mediating and moderating  factors affecting variability in neurodevelopmental, behavioral, and  socio-emotional impact of ZIKV exposure on infants prenatally and postnatally
Develop novel, simple, feasible and  cost-effective testing methods and/or strategies for infection screening during  pregnancy
Develop novel, simple, rapid, feasible and cost  effective testing methods and/or strategies for infection screening in the  infant
Research to develop lab-based or point-of-care  diagnosis for ZIKV using saliva as a biofluid
Develop culturally sensitive strategies to  increase knowledge about the relative efficacy of contraceptive methods, and  use that knowledge to plan for pregnancy
Strategies to integrate the discussion of risk  of ZIKV infection into contraceptive counseling and pre-pregnancy and prenatal  care at medical facilities in ZIKV endemic areas
Determine long-term implications of ZIKV  infection in non-pregnant women and men including impact on fertility and  subsequent pregnancy
Studies to ascertain if ZIKV is present in  reproductive fluids such as semen, cervical mucus, vaginal secretions and/or  follicular fluid; persistence of ZIKV in these fluids; and the mechanisms by  which ZIKV enters the reproductive tract
Studies on effects of ZIKV on in vitro  fertilization
Studies on whether ZIKV can be transmitted by  direct sexual contact or artificial reproductive technology procedures
Once causality is demonstrated, studies on  vaccine development in pregnant women and children
Once causality is demonstrated, development of  methods to explain risk of ZIKV infection and risk of harm to the fetus to  pregnant women and women who are planning to become pregnant
Possible funding opportunities that can be used to pursue  these research activities include:
PA-16-031,  Advancing Understanding, prevention, and management of Infections Transmitted  from Women to their Infants (R21)
PA-16-032,  Advancing Understanding, prevention, and management of Infections Transmitted  from Women to their Infants (R01)
NOT-TW-16-001,  Parallel Funding Initiative for Collaborative Research Between Investigators in  the USA and in the State of Sao Paulo, Brazil
PAR-16-061,  Natural History of Disorders Identifiable by Screening of Newborns (R01)
PAR-14-331,  Global Brain and Nervous System Disorders Research Across the Lifespan (R21)
PAR-14-332,  Global Brain and Nervous System Disorders Research Across the Lifespan (R01)
PAR-15-192 ,  Immune System Plasticity in the Pathogenesis and Treatment of Complex Dental,  Oral, and Craniofacial Diseases (R01)
PAR-15-193,  Immune System Plasticity in the Pathogenesis and Treatment of Complex Dental,  Oral, and Craniofacial Diseases (R21)
PA-13-302,  R01 Research Project Grant  
PA-13-303,  R21 Exploratory/Developmental Research Grant   

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