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本帖最后由 randomqd 于 2016-8-16 12:20 编辑 . M9 ~& P* M' U+ E
) a3 d3 E/ T) I& z/ P6 s1st Edition
2 i- ~8 l8 c9 c0 JAuthors: Joo Chuan Tong Shoba Ranganathan
2 ~2 G$ C. ?. P5 {' T6 P9 q4 YElectronic ISBN 9781908818416 Print ISBN 9781907568411 I g0 S" f5 N6 \* |* \- p- t5 C3 D
8 e b6 Z9 I d$ ^- w" h" @! oDescription. v! M/ b5 S0 ?
Computational pre-screening of antigens is now routinely applied to the discovery of vaccine candidates.
6 \2 R; ^+ L( U( m$ r# }: IComputer-aided vaccine design is a comprehensive introduction to this exciting field of study. The book is intended to be a textbook for researchers and for courses in bioinformatics, as well as a laboratory reference guide. It is written mainly for biologists who want to understand the current methods of computer-aided vaccine design. The contents are designed to help biologists appreciate the underlying concepts and algorithms used, as well as limitations of the methods and strategies for their use. Chapters include: MHC and T cell responses; Immunoglobulins and B cell responses; Scientific publications and databases; Database design; Computational T cell vaccine design; Computational B cell vaccine design; infectious disease informatics; Vaccine safety and quality assessments; and Vaccine adjuvant informatics.
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) }3 F* y4 ]6 j* C- N; lTable of Contents
* l- O6 k( F l1 Q- K5 F5 C& P' tList of figures% n4 o, T3 o2 o/ K" ~' o
List of abbreviations
; Z$ H+ z8 P* w2 uAbout the authors) g& ^% s9 Q" L0 ^3 G" f/ \1 |# I; r
Preface1 x& v7 u! N; ^! x
Chapter 1: MHC and T cell responses3 O- T; ]; o% {0 p6 T) ~! M
Abstract:
6 y5 g2 X) O- ?: q6 Q9 N1.1 Genetic organization of the MHC/ g* a( g/ E$ }, B) P
1.2 MHC structure9 i* p$ m% r/ Z( Z) M
1.3 MHC function1 n3 h* ]) O4 f0 [
1.4 Peptide binding
& h2 g9 ^2 s ?% SChapter 2: Immunoglobulins and B cell responses' w# ^+ W. T7 a/ \7 i
Abstract:
* t' {4 y; _9 L% m& A0 H2.1 Types of immunoglobulins3 r' }# F$ R2 I( l: `* ] A
2.2 Immunoglobulin structure, q/ J+ |0 U; z/ P# t
2.3 Immunoglobulin function8 e: f& u& O2 g" w- s
2.4 Antigen binding ], |; ~ l: N: @
Chapter 3: Scientific publications and databases
' _7 ~; G% i \+ M7 a* l5 sAbstract:
$ u. f, e- \* \" t$ o! b4 M. L0 D3.1 Bibliographical information
: B1 |5 b/ d" C7 }% |: Q) r# q- G( F) N( E3.2 Searching the literature. U/ p7 d/ z4 C! y& a: o
3.3 General databases containing information on genes and proteins
/ `% v1 I) ^" s u3.4 Immunological databases$ g% b: R* a7 Z6 E/ X4 S1 `
3.5 Small molecule databases
7 t) B- |8 T+ q( K2 ^ ?0 B1 ZChapter 4: Database design B, m% \4 _2 y: R% E! ^; r
Abstract:6 R5 F' N4 u- ~( e
4.1 Fundamentals of database design- V1 j; X' A( j3 u
4.2 ER diagram. n4 o& A- Z7 Q, y* w8 q
4.3 Normalization and normal forms9 V" M0 @% z- I3 l
Chapter 5: Computational T cell vaccine design
. ^( U; p# P; iAbstract:0 e5 c9 s/ |, T3 B; C
5.1 Sequence-based methods
5 O) X" d6 r+ x- w5.2 Structure-based methods
% S2 B2 z. s# ]& F z" r5.3 Broad-based T cell vaccine design5 y- G$ z4 _# n0 G" p
Chapter 6: Computational B cell vaccine design0 v2 i2 A8 O9 J( S" u; I& m
Abstract:
8 h4 a) B: y- \/ r6.1 Sequence-based methods+ M/ }5 s# Y; {: h
6.2 Structure-based methods7 ]: A$ q) ~4 h& F j# l3 y
Chapter 7: Infectious disease informatics( a$ s5 [1 p0 S! n
Abstract:
% ^4 o) X2 X2 R6 A7 \! i7.1 Infectious diseases in history- a- \3 I7 F) r6 [: y4 j% R K
7.2 Microbial sequence analysis7 _5 c) I( g8 }
7.3 Detecting natural selection in molecular evolution0 W5 O& g2 t* B1 T% e
Chapter 8: Vaccine safety and quality assessments5 E% u: ? N& J) e5 h
Abstract:; z0 S, u5 g0 M t' r' I
8.1 Assessment of ADME/Tox deficiencies3 G' Q4 _) Q$ ~% Q9 I* {/ S% k
8.2 Assessment of allergenicity$ ~; z# S( ~$ @4 v4 X
Chapter 9: Vaccine adjuvant informatics
3 x1 z7 D9 N' d! V! YAbstract:5 u/ G7 S# D4 n1 O z. X
9.1 Virtual combinatorial library
$ |: @- L9 L& N; n9.2 Chemical file formats
; Z2 j* {# d# r0 G6 K* S! R+ A$ J6 W9.3 Considerations for virtual library design
, Z o, F% H5 w8 J) r1 ?5 |Index: E8 N1 [2 j3 G5 M9 E0 W
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发表于 2016-8-16 12:18:44
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发表于 2016-10-9 10:55:32
