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本帖最后由 randomqd 于 2016-8-16 12:20 编辑 0 a0 r! |' `& E* R8 z- n
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1st Edition/ l8 `2 b0 c5 o4 a& g1 p8 r6 H
Authors: Joo Chuan Tong Shoba Ranganathan
1 r. |% y- X0 c( [5 }" G6 TElectronic ISBN 9781908818416 Print ISBN 9781907568411
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Description
8 J3 u' c/ `% K4 QComputational pre-screening of antigens is now routinely applied to the discovery of vaccine candidates.
! a* X& C% h2 IComputer-aided vaccine design is a comprehensive introduction to this exciting field of study. The book is intended to be a textbook for researchers and for courses in bioinformatics, as well as a laboratory reference guide. It is written mainly for biologists who want to understand the current methods of computer-aided vaccine design. The contents are designed to help biologists appreciate the underlying concepts and algorithms used, as well as limitations of the methods and strategies for their use. Chapters include: MHC and T cell responses; Immunoglobulins and B cell responses; Scientific publications and databases; Database design; Computational T cell vaccine design; Computational B cell vaccine design; infectious disease informatics; Vaccine safety and quality assessments; and Vaccine adjuvant informatics.. ~! O8 e& }0 N/ `3 s
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Table of Contents
4 w9 O% q) m3 h: w1 c5 RList of figures$ q3 a% h) C# h" j9 Y @
List of abbreviations
: W F2 X) d6 p; r3 B3 G3 aAbout the authors
9 Z$ w" I/ S M) l& `* APreface. o: R b- v' w3 _5 e: m
Chapter 1: MHC and T cell responses
6 n3 V7 ~) {- q$ SAbstract:
: q) R; z( E2 @1 W$ L1.1 Genetic organization of the MHC
. W! N8 W+ o$ J ]. }1.2 MHC structure
9 k1 ^0 ? n% @: q4 L1.3 MHC function0 ~$ O: \. O9 {+ B1 O8 f4 S
1.4 Peptide binding% M4 Y4 u- X% \. o
Chapter 2: Immunoglobulins and B cell responses
0 c& S! L! _) }8 s9 oAbstract:: \' S" n5 |8 g) r
2.1 Types of immunoglobulins @5 F% m9 P( J* H$ W
2.2 Immunoglobulin structure
+ o/ ^9 O2 X, `* U6 ]' W2.3 Immunoglobulin function
! X8 [0 e, C I1 F+ I2.4 Antigen binding$ J: T3 @5 F4 U4 W4 d8 Z; _0 c
Chapter 3: Scientific publications and databases% t& G! J0 Y& }: `
Abstract:
2 y! C& q# [* V( `( o5 i; Z3.1 Bibliographical information0 m/ Q9 l8 u5 a+ _* c1 E9 a3 @
3.2 Searching the literature2 n7 T$ P" O6 X) Q8 G/ d) |8 w
3.3 General databases containing information on genes and proteins
Z/ n0 }# k6 N1 }% k) k3.4 Immunological databases( L7 f9 b; s. n: a
3.5 Small molecule databases
0 z5 ]6 b1 U& E% ZChapter 4: Database design
( }/ z2 J2 J" rAbstract:( a7 H% M( r( v% x
4.1 Fundamentals of database design
" ^0 ?. L( b3 R1 {* v* P4.2 ER diagram
: i# K r# x. g% B' |1 [, j4.3 Normalization and normal forms1 @( W; P4 v9 f$ h
Chapter 5: Computational T cell vaccine design2 e1 a8 G- G0 C7 M2 F
Abstract:, D: H a6 Y2 E$ q, }" r5 W2 v
5.1 Sequence-based methods6 w8 g! b8 Y r' `
5.2 Structure-based methods" Y4 O4 v3 Q/ P P" L" E1 Q
5.3 Broad-based T cell vaccine design
2 A$ g/ j2 u, {' y( |6 QChapter 6: Computational B cell vaccine design
9 J1 X2 b# H5 N% L/ V: e# CAbstract:
. W% Q" L+ g( X* s9 H$ D+ [6.1 Sequence-based methods
+ O' b8 }8 P9 I* H6.2 Structure-based methods" @1 @8 G% ]0 h6 V' O$ ~+ x
Chapter 7: Infectious disease informatics
/ E l6 R, o! z: yAbstract:: Y: e+ i/ n; W0 |" [" }
7.1 Infectious diseases in history8 G0 F8 V) P* |* g* p8 F
7.2 Microbial sequence analysis
: S2 v% l$ D) @. ~, i7.3 Detecting natural selection in molecular evolution
; Y0 g. @& H. }. m' Q$ w5 I: jChapter 8: Vaccine safety and quality assessments0 @- m# q8 X F: ~3 g6 F
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8.1 Assessment of ADME/Tox deficiencies9 n& g1 Y/ H; P9 ]9 c7 O
8.2 Assessment of allergenicity
8 ]1 _. Q- J2 V. b7 X6 T# OChapter 9: Vaccine adjuvant informatics$ ^# y6 E. `- e* I: V1 @+ T! |
Abstract:6 W- a' g! a, Q% r+ ?
9.1 Virtual combinatorial library9 S) k: m2 t/ Z8 K
9.2 Chemical file formats, b+ o0 b# Q7 H1 k: R. ?2 q8 |" P
9.3 Considerations for virtual library design
, Y, g* r: j9 | I4 `Index
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发表于 2016-8-16 12:18:44
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发表于 2016-10-9 10:55:32
