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| | Registration Address: Wanda Realm Hotel Wuhan No.105 Donghu Road, Wuchang District, Wuhan |
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| | Welcome and opening remarks Chair – Zhiming Yuan (Principle Investigator, Wuhan Institute of Virology, CAS) China: Yaping Zhang (Vice President/ Academician, Chinese Academy of Sciences) Xinwen Chen (Director General/ Principle Investigator, Wuhan Institute of Virology, CAS) U.S.: Linda Saif (Academician, Ohio State University) David Relman (Academician, Stanford University) James LeDuc (Professor, Galveston National Laboratory) - Technical aspects of high-containment lab sustainability: challenges of maintaining a maximum containment laboratory |
| Tea break and group photo |
Session 1 : Gain of function research, gene editing, targeting and delivery and other novel biotechnology -Thoughts on Gain of function research, gene editing, targeting and delivery and other novel biotechnology
-The recent advances in technology and their applications Chair –Yanyi Wang (Deputy Director General/ Principle Investigator, Wuhan Institute of Virology, CAS) |
| David Relman (Academician, Stanford University) Genome engineering and other life sciences technologies: challenges and opportunities |
| Zhihong Hu (Principle Investigator, Wuhan Institute of Virology, CAS) Construction and rescue of a functional synthetic baculovirus |
| Wensheng Wei (Professor, Peking University) High-throughput functional genomics: coding, non-coding and beyond |
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Session 2: Public health response to outbreaks and issues -Collaborating on influenza, including avian influenza -Host-pathogen interaction (pathogenesis) Chair –James Le Duc (Professor, Galveston National Laboratory) |
| Xia Jin (Principle Investigator, Institut Pasteur of Shanghai, CAS) Dengue Immune Sera Enhance Zika Virus Infection in Human Peripheral Blood Monocytes |
| Jianping Zuo (Principle Investigator, Shanghai Institute of Materia Medica, CAS) Anti-viral drug discovery in SIMM |
| Rui Gong (Principle Investigator, Wuhan Institute of Virology, CAS) Engineered human antibody constant domain as candidate against Ebola virus |
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| Peiyong Shi (Professor, University of Texas) Antiviral drug discovery and development |
| James Le Duc (Professor, Galveston National Laboratory) Improving the laboratory’s role in emergency health response, Communications during crisis |
| Round Table Discussion Chair –Zhiming Yuan (Principle Investigator, Wuhan Institute of Virology, CAS) James Le Duc (Professor, Galveston National Laboratory) - Review of day one and plan for day two |
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| Session 3: Emerging infectious diseases and global health security -Anti-viral countermeasures (strategy and R&D) -Improving the laboratory’s role in emergency health response (Discussion of issues like dedicated high-containment hospital room' in the lab vs. working with local hospital for care of a LAI patient outside the lab) Chair –Peiyong Shi (Professor, University of Texas) |
| George F. Gao (Academician, Institute of Microbiology, CAS) TBD |
| Jiahai Lu (Professor, Zhongshan School of Medicine, Sun Yat-Sen University) A One Health Strategy for Responding to Emerging Infectious Diseases |
| Zhengli Shi (Principle Investigator, Wuhan Institute of Virology, CAS) |
| Mifang Liang (Principle Investigator, National Institute for Viral Disease Control and Prevention) Epidemiological characteristics of Severe fever with thrombocytopenia syndrome (SFTS) in China from first discovery |
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| Linda Saif (Academician, Ohio State University) Animal Coronaviruses: Global Threats to Humans and Animals |
| Chengfeng Qin (Professor, The Academy of Military Medical Sciences) Existing weapons against the emerging Zika virus |
| David Swayne (Director, USDA Southeast Poultry Research Laboratory) Avian Influenza at the Animal-Human Interface: Global Challenges for Scientific Contributions to Control |
| Gong Cheng (Professor, Qinghua University) Non-structural Protein 1: A Key for Flavivirus Transfer from Host to Vector |
| Peiyong Shi (Professor, University of Texas) Rapid response to Zika virus emergence: Diagnostics and vaccine development |
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Session 4: High-level biosafety Laboratory: construction, commissioning, and sustainment -Requirements for high containment labs in China and the U.S and discussion of recent projects -Community relations and public communication -Should biocontainment labs have clinical facilities? -Biocontainment maintenance and operations / Outbreak response / Importance of reference collections and reagents Chair – Zhiming Yuan (Principle Investigator, Wuhan Institute of Virology, CAS) |
| Peijun Zhai (Division Director, China National Accreditation Service for Conformity Assessment) Brief and Status Quo on China Accreditation for Biosafety Laboratories |
| Thomas Ksiazek (Professor, Galveston National Laboratory) Biocontainment operations and maintenance and UTMB training for other containment facilities |
| Zhigao Bu (Director General/Principle Investigator, Harbin Veterinary Research Institute, the Chinese Academy of Agricultural Sciences) Design, Construction and Operation of National High Containment Facilities for Animal Diseases Control and Prevention |
| Yunzhang Hu (Principle Investigator, Institute of Medical Biology Chinese Academy of Medical Sciences) TBD |
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Session 5: Biosafety, biosecurity and bioethics - New technology for laboratory biological risk management - Improving response to incidents at the lab (fire, police, environment release and paramedic) - Improving biosafety and biosecurity training - Laboratory leadership, culture and ethics Chair –David R. Franz (Professor, US Army Medical Research Institute of Infectious Diseases) |
| Zhiming Yuan (Principle Investigator, Wuhan Institute of Virology, CAS) Biosafety and Bioethical for Infectious Disease Control Research |
| Thomas Ksiazek (Professor, Galveston National Laboratory) Regulatory issues affecting the operation of a functional high containment lab: Obtaining, shipping, maintaining and exchanging high hazard pathogens in today’s regulatory environment. Does the science matter? |
| David R. Franz (Professor, US Army Medical Research Institute of Infectious Diseases) Leadership, Responsibility and Progress |
| Conclusions Chair –Zhiming Yuan (Principle Investigator, Wuhan Institute of Virology, CAS) James Le Duc (Professor, Galveston National Laboratory) - Conclusions from the meeting and discussion on possible roles of CAS and NAS to enhance cooperation between the U.S. and China on Emerging Infections, Laboratory Safety and Global Health Security - Concluding remarks by Zhiming Yuan and David Franz Co-chairs |
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| | Leave for Zhengdian Park, Wuhan Institute of Virology, CAS |
| A visit to Wuhan P4 Lab and discussions |