[转移贴]miRNA资料分享

cao1976

原贴由苹果花开发表于 2008-10-16 20:16
http://biosky.haotui.com/thread-6825-1-7.html

miRNA,siRNA都可能与植物PTGS有关，我看好基因沉默与植物病毒的互作关系研究，大家觉得呢？
我这有几篇miRNA的综述，大家有好的资料的话，请分享！！

cao1976

rojjer发表于 2009-2-21 22:02
Review

Cell最新综述：
Origins and Mechanisms of miRNAs and siRNAs
Richard W. Carthew1,,andErik J. Sontheimer1,,

1 Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University, 2205 Tech Drive, Evanston, IL 60208-3500, USA

Summary
Over the last decade, 2030 nucleotide RNA molecules have emerged as critical regulators in the expression and function of eukaryotic genomes. Two primary categories of these small RNAsshort interfering RNAs (siRNAs) and microRNAs (miRNAs)act in both somatic and germline lineages in a broad range of eukaryotic species to regulate endogenous genes and to defend the genome from invasive nucleic acids. Recent advances have revealed unexpected diversity in their biogenesis pathways and the regulatory mechanisms that they access. Our understanding of siRNA- and miRNA-based regulation has direct implications for fundamental biology as well as disease etiology and treatment.
http://www.cell.com/abstract/S0092-8674%2809%2900083-X