计算机辅助疫苗设计Computer-Aided Vaccine Design

randomqd

- w% @; v8 a* D- i6 A1st Edition
Authors:  Joo Chuan Tong Shoba Ranganathan
Electronic ISBN 9781908818416  Print ISBN 9781907568411

5 w1 y$ ~- E2 i/ Y3 QDescription
/ L: E+ f/ \# u- nComputational pre-screening of antigens is now routinely applied to the discovery of vaccine candidates.
Computer-aided vaccine design is a comprehensive introduction to this exciting field of study. The book is intended to be a textbook for researchers and for courses in bioinformatics, as well as a laboratory reference guide. It is written mainly for biologists who want to understand the current methods of computer-aided vaccine design. The contents are designed to help biologists appreciate the underlying concepts and algorithms used, as well as limitations of the methods and strategies for their use. Chapters include: MHC and T cell responses; Immunoglobulins and B cell responses; Scientific publications and databases; Database design; Computational T cell vaccine design; Computational B cell vaccine design; infectious disease informatics; Vaccine safety and quality assessments; and Vaccine adjuvant informatics.

9 a9 }: F& D; n
' M: c6 K0 K4 Q7 t4 B+ [/ XTable of Contents
List of figures
4 y3 L0 G5 b- R* A3 cList of abbreviations
9 O+ g& ]) E+ V/ Q' o0 b) [About the authors
Preface
! ]4 y1 {$ m# Q) T2 `, ~( [* fChapter 1: MHC and T cell responses
! v7 v4 R% [- f/ a, {Abstract:
1.1 Genetic organization of the MHC
$ |5 n1 X- ^: q! L) \1.2 MHC structure
1.3 MHC function
$ @7 L- L* q, x2 t( I/ D1.4 Peptide binding
0 |  r% ~9 u3 pChapter 2: Immunoglobulins and B cell responses
Abstract:
9 L" h8 P! T- T3 L2.1 Types of immunoglobulins
2.2 Immunoglobulin structure
7 ~# ]5 O1 B! }0 E; [% ~2.3 Immunoglobulin function
2.4 Antigen binding
" k5 q9 ?+ t3 l3 N9 k- E: MChapter 3: Scientific publications and databases
4 e% v: O6 M6 d) U/ U' z1 q' L2 a$ bAbstract:
0 `9 r- x+ w. g0 V) R7 V3.1 Bibliographical information
3.2 Searching the literature
$ H+ L# D0 n- j( s3.3 General databases containing information on genes and proteins
% H9 @% B, [. f- D  _3.4 Immunological databases
( ?: x; q' Y  S3.5 Small molecule databases
Chapter 4: Database design
Abstract:
' X# b. b3 i5 y% P! l' Q4.1 Fundamentals of database design
4.2 ER diagram
4.3 Normalization and normal forms
; M% }* {* R/ {* e3 m8 LChapter 5: Computational T cell vaccine design
Abstract:
% X$ D2 I  [' w5 a5.1 Sequence-based methods
5.2 Structure-based methods
2 ^) m% u! ~/ S+ s, l. |4 _# G5.3 Broad-based T cell vaccine design
Chapter 6: Computational B cell vaccine design
Abstract:
6.1 Sequence-based methods
6.2 Structure-based methods
: J4 @+ ^' l4 T. [% lChapter 7: Infectious disease informatics
8 o0 M1 Z( o" N! m/ Y" x5 I3 `Abstract:
7.1 Infectious diseases in history
7.2 Microbial sequence analysis
/ s" K" a# V$ E- y* ?8 l5 e& A, e# N: G7.3 Detecting natural selection in molecular evolution
3 R1 e4 O* B/ J. e7 PChapter 8: Vaccine safety and quality assessments
Abstract:
8.1 Assessment of ADME/Tox deficiencies
8.2 Assessment of allergenicity
3 F9 g/ I" l* ~& YChapter 9: Vaccine adjuvant informatics
2 \- f/ h" Q1 ~' x+ J) U3 ]Abstract:
3 m! V/ b# [0 ]$ }7 z, I9.1 Virtual combinatorial library
$ E) D) Q0 F1 d  z' y( m4 [  w9.2 Chemical file formats
% w7 r+ C4 C: ^. _( Z9.3 Considerations for virtual library design
5 D9 h1 T2 I  bIndex

- l9 V  c- @' D) b9 t6 Z* `

原文下载地址：
3 I" z* K3 @8 O

游客，如果您要查看本帖隐藏内容请回复

3 L2 @, n8 j$ F( d' A
$ M, P8 _+ W7 z9 |% ]% c

dianhh012786

楼主厉害，谢谢分享

chenzongxiang

感谢楼主分享！

freud1981213

thank you for your sharing

Ascovirus

thank you so much for your sharing

蓝色飞雪

从来没听说过的概念，厉害了

aycdcjmkzp

谢谢分享

tangran0323

看着高大上，下载下来看看

tonrol

谢谢分享

cxp

谢谢分享
) F) F7 G' Z# P5 F5 a& o6 q

Fjh

thank you for your sharing

Fjh

( S& v  `1 |2 ]thank you for your sharing

迷你大笨象

非常感谢你的分享
/ E" a, P; ^1 z+ T, @  h6 c/ k# q

xiaoniao1216

谢谢分享，认真学习

xxdxxd2009

厉害呀，楼主

DennyHu

谢谢分享

ASun

感谢楼主分享！

lincoln2013v

谢谢分享

蛐蛐

谢谢分享

LMC

感谢楼主！