[转移帖]关于病毒样颗粒自组装问题

cao1976

原帖由论坛会员lifeng发表于 2010-9-15 22:52 |

请问病毒样颗粒自组装是怎么组装的，原理是什么？有相关的研究吗？谢谢

cao1976

Rojjer发表于 2010-9-22 11:10 | ：

病毒的体内Self-assembly
特别是VLP的体内、体外Self-assembly  （HPV的L1蛋白）机理似乎目前还不是很明确。
（引用：A number of questions remain to be answered regarding the processes of influenza virus assembly and budding. For example, what is the individual role of each protein in virus morphogenesis? are contacts between RNPs and other viral components required for virus assembly? what is the minimum set of viral proteins needed to initiate the bending of the membrane, a process that eventually will lead to the formation of budded virions? what is the major driving force in this process?）

这些自我组装功能的获得都与某些蛋白的特性有关，或者特殊结构，比如在流感病毒的M1以及HPV的L1都含有一段疏水区，这与他们和细胞膜的脂质分子相互作用从而介导组装释放有很大关系。
具体机理个人也不是很清楚。
两篇文献供楼主参考：
1，生物结构自组装（张先恩）（直接搜索可以下载）
2，Influenza Virus Matrix Protein Is the Major Driving Force in Virus Budding
http://ukpmc.ac.uk/articles/PMC1 ... B5E4AC35363597.jvm1
期待高手指点。