|
发表于 2015-11-18 09:34:55
|
显示全部楼层
Tespa1 is involved in late thymocyte development through the regulation of TCR-mediated signaling
9 E( M) q- H+ b0 ^) U5 }3 y' F, f% M9 p* _9 B
Di Wang, Mingzhu Zheng, Lei Lei, Jian Ji, Yunliang Yao, Yuanjun Qiu, Lie Ma, Jun Lou, Chuan Ouyang, Xue Zhang, Yuewei He, Jun Chi, Lie Wang, Ying Kuang, Jianli Wang, Xuetao Cao & Linrong Lu8 c, T; ?5 [$ p' t% c
" @2 M" V4 x( G5 I5 SSignaling via the T cell antigen receptor (TCR) during the CD4+CD8+ double-positive developmental stage determines thymocyte selection and lineage commitment. Here we describe a previously uncharacterized T cell–expressed protein, Tespa1, with critical functions during the positive selection of thymocytes. Tespa1−/− mice had fewer mature thymic CD4+ and CD8+ T cells, which reflected impaired thymocyte development. Tespa1 associated with the TCR signaling components PLC-γ1 and Grb2, and Tespa1 deficiency resulted in attenuated TCR signaling, as reflected by defective activation of the Erk–AP-1 and Ca2+-NFAT pathways. Our findings demonstrate that Tespa1 is a component of the TCR signalosome and is essential for T cell selection and maturation through the regulation of TCR signaling during T cell development.
8 v% ^( e# [+ j' M$ e8 `! y( \ j! E& r
鲁教授又出好文章了。 |
|