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求帮忙下这篇文献

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发表于 2015-11-17 22:50:45 | 显示全部楼层 |阅读模式
http://www.nature.com/ni/journal/v13/n6/full/ni.2301.html顺便下一下补充的pdf
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发表于 2015-11-18 09:34:55 | 显示全部楼层
Tespa1 is involved in late thymocyte development through the regulation of TCR-mediated signaling( H4 W- C  b  m- S" H* Y
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Di Wang,        Mingzhu Zheng,        Lei Lei,        Jian Ji,        Yunliang Yao,        Yuanjun Qiu,        Lie Ma,        Jun Lou,        Chuan Ouyang,        Xue Zhang,        Yuewei He,        Jun Chi,        Lie Wang,        Ying Kuang,        Jianli Wang,        Xuetao Cao        & Linrong Lu
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Signaling via the T cell antigen receptor (TCR) during the CD4+CD8+ double-positive developmental stage determines thymocyte selection and lineage commitment. Here we describe a previously uncharacterized T cell–expressed protein, Tespa1, with critical functions during the positive selection of thymocytes. Tespa1−/− mice had fewer mature thymic CD4+ and CD8+ T cells, which reflected impaired thymocyte development. Tespa1 associated with the TCR signaling components PLC-γ1 and Grb2, and Tespa1 deficiency resulted in attenuated TCR signaling, as reflected by defective activation of the Erk–AP-1 and Ca2+-NFAT pathways. Our findings demonstrate that Tespa1 is a component of the TCR signalosome and is essential for T cell selection and maturation through the regulation of TCR signaling during T cell development.
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# [2 \1 X8 n; g5 W6 @鲁教授又出好文章了。

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发表于 2015-11-18 11:04:50 | 显示全部楼层
文件有点大,留个邮箱吧,我发你

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 楼主| 发表于 2015-11-19 13:09:02 | 显示全部楼层
ipsvirus 发表于 2015-11-18 11:04* C1 j" n" e% K: M% A# O
文件有点大,留个邮箱吧,我发你

# p  M# O6 b" x% v- x1455710563@qq.com,谢谢啦

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 楼主| 发表于 2015-11-19 13:09:44 | 显示全部楼层
marine0425030 发表于 2015-11-18 09:34# y* {( r: C- g* e
Tespa1 is involved in late thymocyte development through the regulation of TCR-mediated signaling
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未来的老板

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发表于 2015-11-19 13:17:49 | 显示全部楼层
zszhao 发表于 2015-11-19 13:09* k# y  n" e) R- r) `, W' P8 ?
,谢谢啦

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