|
|
Tespa1 is involved in late thymocyte development through the regulation of TCR-mediated signaling
5 p; M: A5 ^' a/ ?
( i7 I6 Q( M1 O6 l Di Wang, Mingzhu Zheng, Lei Lei, Jian Ji, Yunliang Yao, Yuanjun Qiu, Lie Ma, Jun Lou, Chuan Ouyang, Xue Zhang, Yuewei He, Jun Chi, Lie Wang, Ying Kuang, Jianli Wang, Xuetao Cao & Linrong Lu. U7 T/ [0 F7 a0 P3 D
, ?7 e: z }2 n/ sSignaling via the T cell antigen receptor (TCR) during the CD4+CD8+ double-positive developmental stage determines thymocyte selection and lineage commitment. Here we describe a previously uncharacterized T cell–expressed protein, Tespa1, with critical functions during the positive selection of thymocytes. Tespa1−/− mice had fewer mature thymic CD4+ and CD8+ T cells, which reflected impaired thymocyte development. Tespa1 associated with the TCR signaling components PLC-γ1 and Grb2, and Tespa1 deficiency resulted in attenuated TCR signaling, as reflected by defective activation of the Erk–AP-1 and Ca2+-NFAT pathways. Our findings demonstrate that Tespa1 is a component of the TCR signalosome and is essential for T cell selection and maturation through the regulation of TCR signaling during T cell development. u. B' f# C. t* z- m# g
/ ^( S) P2 r5 Y$ j* e
鲁教授又出好文章了。 |
|
发表于 2015-11-17 22:50:45
QQ好友和群
QQ空间
腾讯微博
腾讯朋友
收藏
分享
支持
反对
发表于 2015-11-18 11:04:50
楼主
