求帮忙下这篇文献

zszhao

http://www.nature.com/ni/journal/v13/n6/full/ni.2301.html顺便下一下补充的pdf
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marine0425030

Tespa1 is involved in late thymocyte development through the regulation of TCR-mediated signaling

Di Wang,        Mingzhu Zheng,        Lei Lei,        Jian Ji,        Yunliang Yao,        Yuanjun Qiu,        Lie Ma,        Jun Lou,        Chuan Ouyang,        Xue Zhang,        Yuewei He,        Jun Chi,        Lie Wang,        Ying Kuang,        Jianli Wang,        Xuetao Cao        & Linrong Lu

Signaling via the T cell antigen receptor (TCR) during the CD4+CD8+ double-positive developmental stage determines thymocyte selection and lineage commitment. Here we describe a previously uncharacterized T cell–expressed protein, Tespa1, with critical functions during the positive selection of thymocytes. Tespa1−/− mice had fewer mature thymic CD4+ and CD8+ T cells, which reflected impaired thymocyte development. Tespa1 associated with the TCR signaling components PLC-γ1 and Grb2, and Tespa1 deficiency resulted in attenuated TCR signaling, as reflected by defective activation of the Erk–AP-1 and Ca2+-NFAT pathways. Our findings demonstrate that Tespa1 is a component of the TCR signalosome and is essential for T cell selection and maturation through the regulation of TCR signaling during T cell development.

鲁教授又出好文章了。

ipsvirus

文件有点大，留个邮箱吧，我发你

zszhao

ipsvirus 发表于 2015-11-18 11:04
! n) H  n. M9 w  G文件有点大，留个邮箱吧，我发你

- d( [, O4 c1 y1455710563@qq.com，谢谢啦

zszhao

marine0425030 发表于 2015-11-18 09:34
, N4 N7 V) K  E9 Y' W* XTespa1 is involved in late thymocyte development through the regulation of TCR-mediated signaling

  ...

2 t+ A* u; y) \未来的老板

ipsvirus

zszhao 发表于 2015-11-19 13:09
，谢谢啦

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