细菌代谢和抗生素功效

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Bacterial Metabolism and Antibiotic Efficacy
Jonathan M. Stokes Allison J. Lopatkin Michael A. Lobritz James J. Collins Published:July 03, 2019

DOI: https://doi.org/10.1016/j.cmet.2019.06.009

Summary
Antibiotics target energy-consuming processes. As such, perturbations to bacterial metabolic homeostasis are significant consequences of treatment. Here, we describe three postulates that collectively define antibiotic efficacy in the context of bacterial metabolism: (1) antibiotics alter the metabolic state of bacteria, which contributes to the resulting death or stasis; (2) the metabolic state of bacteria influences their susceptibility to antibiotics; and (3) antibiotic efficacy can be enhanced by altering the metabolic state of bacteria. Altogether, we aim to emphasize the close relationship between bacterial metabolism and antibiotic efficacy as well as propose areas of exploration to develop novel antibiotics that optimally exploit bacterial metabolic networks.