Neuraminidase Is an Important Target for Influenza Vaccination

wwwkkk83

Gilchuk et al. (2019) and Zhu et al. (2019) provide detailed structural information about epitopes on influenza virus N9 neuraminidase and characterize breadth, potency, mechanism of action, and in vivo protective effects of human antibodies targeting these epitopes. The findings highlight the importance of neuraminidase as a target for improved influenza virus vaccines.

DOI:https://doi.org/10.1016/j.chom.2019.11.006

wwwkkk83

References
Air G.M.
Influenza neuraminidase.
Influenza Other Respir. Viruses. 2012; 6: 245-256
View in Article
Scopus (100)
PubMed
Crossref
Google Scholar
Chen Y.Q.
Wohlbold T.J.
Zheng N.Y.
Huang M.
Huang Y.
Neu K.E.
Lee J.
Wan H.
Rojas K.T.
Kirkpatrick E.
et al.
Influenza infection in humans induces broadly cross-reactive and protective neuraminidase-reactive antibodies.
Cell. 2018; 173: 417-429
View in Article
Scopus (19)
PubMed
Abstract
Full Text
Full Text PDF
Google Scholar
Gilchuk I.M.
Bangaru S.
Gilchuk P.
Irving R.P.
Kose N.
Bombardi R.G.
Thornburg N.J.
Creech B.
Edward K.M.
Li S.
et al.
Influenza H7N9 virus neuraminidase-specific human monoclonal antibodies inhibit viral egress and protect from lethal influenza infection in mice.
Cell Host Microbe. 2019; 26 (this issue): 715-728
View in Article
Google Scholar
Krammer F.
The human antibody response to influenza A virus infection and vaccination.
Nat. Rev. Immunol. 2019; 19: 383-397
View in Article
Scopus (6)
PubMed
Crossref
Google Scholar
Krammer F.
Fouchier R.A.M.
Eichelberger M.C.
Webby R.J.
Shaw-Saliba K.
Wan H.
Wilson P.C.
Compans R.W.
Skountzou I.
Monto A.S.
NAction! how can neuraminidase-based immunity contribute to better influenza virus vaccines?.
MBio. 2018;
https://doi.org/10.1128/mBio.02332-17
View in Article
Scopus (29)
PubMed
Crossref
Google Scholar
Monto A.S.
Kendal A.P.
Effect of neuraminidase antibody on Hong Kong influenza.
Lancet. 1973; 1: 623-625
View in Article
PubMed
Abstract
Google Scholar
Murphy B.R.
Kasel J.A.
Chanock R.M.
Association of serum anti-neuraminidase antibody with resistance to influenza in man.
N. Engl. J. Med. 1972; 286: 1329-1332
View in Article
PubMed
Crossref
Google Scholar
Palese P.
Compans R.W.
Inhibition of influenza virus replication in tissue culture by 2-deoxy-2,3-dehydro-N-trifluoroacetylneuraminic acid (FANA): mechanism of action.
J. Gen. Virol. 1976; 33: 159-163
View in Article
PubMed
Crossref
Google Scholar
Schulman J.L.
Khakpour M.
Kilbourne E.D.
Protective effects of specific immunity to viral neuraminidase on influenza virus infection of mice.
J. Virol. 1968; 2: 778-786
View in Article
PubMed
Google Scholar
Stadlbauer D.
Zhu X.
McMahon M.
Turner J.S.
Wohlbold T.J.
Schmitz A.J.
Strohmeier S.
Yu W.
Nachbagauer R.
Mudd P.A.
et al.
Broadly protective human antibodies that target the active site of influenza virus neuraminidase.
Science. 2019; 366: 499-504
View in Article
Scopus (0)
PubMed
Crossref
Google Scholar
Zhu X.
Turner H.L.
Lang S.
McBride R.
Bangaru S.
Gilchuk I.M.
Yu W.
Paulson J.C.
Crowe Jr., J.E.
Ward A.B.
et al.
Structural basis of protection against H7N9 influenza virus by human anti-N9 neuraminidase antibodies.
Cell Host Microbe. 2019; 26 (this issue): 729-738