|
|
地板
楼主 |
发表于 2015-8-15 10:41:38
|
只看该作者
pumcpzg 发表于 2009-9-25 12:43 ：
丙型肝炎病毒，目前仍只有干扰素和利巴韦林用于临床抗HCV治疗。
利巴韦林抗HCV的可能作用机制： a, immunomodulation promoting TH1 over TH2 phenotype； b, inosine monophosphate dehydrogenase （IMPDH） inhibition leading to GTP depletion； c, direct inhibition of HCV RNA polymerase； d, mutagenesis resulting in reduced virion infectivity.
干扰素治疗丙肝的可能作用机制：
IFN-α has potent antiviral properties. Treatment with IFN-α induces the expression of a range of antiviral effector proteins, of which the best known include 2',5'-oligoadenylate synthetase, double-stranded RNA-activated protein kinase, and the myxovirus proteins.
In addition to its direct antiviral properties, IFN-α has immunomodulatory properties that might contribute to its antiviral efficacy by activating cells and molecules involved in the host antiviral response. Although the exact mechanisms contributing to the clinical efficacy of IFN-α are not completely understood, several indirect antiviral functions have been demonstrated. For example, IFN‑α stimulates the effector function of natural killer cells, cytotoxic T lymphocytes and macrophages, upregulates the expression of major histocompatibility complex class I and class II molecules, induces immunoglobulin synthesis by B cells, and stimulates the proliferation of memory T cells.
————————————————————————————————————————
抗DNA病毒药物
1. 疱疹病毒 DNA合成抑制剂
a. 胸苷激酶激活剂: 嘌呤类似物 (鸟嘌呤) (阿昔洛韦 , 泛昔洛韦, 更昔洛韦, 喷昔洛韦, 伐昔洛韦, 缬更昔洛韦) 、阿糖腺苷 嘧啶类似物 (尿苷) (碘苷, 曲氟胸苷) 、溴夫定
b. 非胸苷激酶激活剂: 膦甲酸
c. 其它 : 二十二烷醇 • 福米韦生 、曲金刚胺
2. 人乳头状瘤病毒 咪喹莫特、鬼臼毒素
3. 牛痘 利福平
4. 痘病毒 Methisazone
5. 乙肝病毒 核苷类似物: 恩替卡韦 、拉米夫定 、替比夫定 、阿德福韦 、替诺福韦 |
|
发表于 2015-8-15 10:38:25
QQ好友和群
QQ空间
腾讯微博
腾讯朋友
收藏
分享
支持
反对
