宾夕法尼亚大学博后机会：MERS病毒先天免疫方向

bigben446

Postdoc position at University of Pennsylvania in lab of Susan Weiss.

Our lab studies coronavirus host interaction focused on innate immune response. We use the well-developed murine coronavirus model of encephalitis and hepatitis for in vitro and in vivo studies as well as newer studies of MERS-CoV to investigate cell types and organ specific interactions of virus with type I interferon signaling response.

Research directions:

1. MHV and MERS-CoV encoded phoshodiesterases that cleave 2’,5’ oligoadenylates  thereby antagonizing RNase L activation.

2. Role of Oligoadenylate Synthetase (OAS) proteins in antiviral response.

3. Cell type and organ specific differences in expression of interferon pathways and the implications for viral pathogenesis

4. Coronavirus antagonism of IFN induction and signaling pathways.

publications:
Zhao et al. (2012) Cell Host & Microbe 11: 607-616.
Zhao et al., (2013) J. Virol 87:8408-8418.
Zhang et al., (2013) Proc Natl Acad Sci 110(32):13114-9.
Zhang et al., (2015) J. Virol 89:3598-3609.
Silverman and Weiss (2014) J Interferon Cytokine Res.34:455-63.


Requirements: PhD, MD or VMD degree, obtained within the last year; experience in viral pathogenesis and/or innate immune response preferred

Please send letter of interest and CV in one pdf file to :
Susan R. Weiss
weisssr@upenn.edu