|
|
发表于 2015-11-18 09:34:55
|
显示全部楼层
Tespa1 is involved in late thymocyte development through the regulation of TCR-mediated signaling4 ~$ T% L9 x* B& a5 v
' c" Z# M: p P
Di Wang, Mingzhu Zheng, Lei Lei, Jian Ji, Yunliang Yao, Yuanjun Qiu, Lie Ma, Jun Lou, Chuan Ouyang, Xue Zhang, Yuewei He, Jun Chi, Lie Wang, Ying Kuang, Jianli Wang, Xuetao Cao & Linrong Lu* |( q' [# G, o( Q' f* x5 Y Z- U
4 \- W1 C( D- c* v5 G, J: q
Signaling via the T cell antigen receptor (TCR) during the CD4+CD8+ double-positive developmental stage determines thymocyte selection and lineage commitment. Here we describe a previously uncharacterized T cell–expressed protein, Tespa1, with critical functions during the positive selection of thymocytes. Tespa1−/− mice had fewer mature thymic CD4+ and CD8+ T cells, which reflected impaired thymocyte development. Tespa1 associated with the TCR signaling components PLC-γ1 and Grb2, and Tespa1 deficiency resulted in attenuated TCR signaling, as reflected by defective activation of the Erk–AP-1 and Ca2+-NFAT pathways. Our findings demonstrate that Tespa1 is a component of the TCR signalosome and is essential for T cell selection and maturation through the regulation of TCR signaling during T cell development.! N1 X1 u" F6 G( Z9 ~& E
; s# @1 s# e" y
鲁教授又出好文章了。 |
|
发表于 2015-11-18 11:04:50
