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本帖最后由 randomqd 于 2016-8-16 12:20 编辑
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1st Edition
8 p0 h( C& Q( z( F; P/ e5 M. |Authors: Joo Chuan Tong Shoba Ranganathan4 z" |9 p1 c. } j7 R8 H; h- Z- E* Z
Electronic ISBN 9781908818416 Print ISBN 9781907568411- d' l0 g8 h* k6 E2 G7 E) |4 S
0 I) s4 g: I$ `- F( rDescription7 p$ u7 U* r- \* X" l/ F" u
Computational pre-screening of antigens is now routinely applied to the discovery of vaccine candidates.. X5 ^! W1 r+ g- n5 F
Computer-aided vaccine design is a comprehensive introduction to this exciting field of study. The book is intended to be a textbook for researchers and for courses in bioinformatics, as well as a laboratory reference guide. It is written mainly for biologists who want to understand the current methods of computer-aided vaccine design. The contents are designed to help biologists appreciate the underlying concepts and algorithms used, as well as limitations of the methods and strategies for their use. Chapters include: MHC and T cell responses; Immunoglobulins and B cell responses; Scientific publications and databases; Database design; Computational T cell vaccine design; Computational B cell vaccine design; infectious disease informatics; Vaccine safety and quality assessments; and Vaccine adjuvant informatics.2 C" x+ k+ ~' I1 i6 @
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Table of Contents
" y7 k/ a9 x* t! gList of figures
8 |' W9 m9 b* A: @4 N% A* p, RList of abbreviations
3 b: H0 T( u. g; E9 uAbout the authors
8 Z4 x0 D( V3 v- L2 EPreface
" @" a7 z: ]# m( |# nChapter 1: MHC and T cell responses
! }5 y* I3 e: R! V/ m* @Abstract:
; W7 F2 i8 C5 W8 ?$ P1.1 Genetic organization of the MHC
# Q1 x- s6 |4 }% ~% t1.2 MHC structure( _0 h- d7 k' u! C) l. r; j
1.3 MHC function [3 i# S) d& m, k1 |& d
1.4 Peptide binding
( W9 G' g" g" L6 N2 pChapter 2: Immunoglobulins and B cell responses- B- H. m0 ]) d# T
Abstract:
5 }9 @, y- a; D- B) a/ T( f% Y( H& O2.1 Types of immunoglobulins, s5 T8 u2 Z2 X" d# d: C! h
2.2 Immunoglobulin structure
) G4 T& g7 Y/ |; ] k2 L2.3 Immunoglobulin function
2 n1 b( W- M+ Y' p6 p2.4 Antigen binding
* u* _0 d# S3 m( z& a( wChapter 3: Scientific publications and databases
, \6 p4 X( _5 D( PAbstract:0 O$ V; J- l/ f
3.1 Bibliographical information8 L; V/ v9 c" Q/ e6 k, N
3.2 Searching the literature9 P: D7 |! g, H1 I- H6 v. ]
3.3 General databases containing information on genes and proteins
6 h8 ]/ I" l9 _, u3.4 Immunological databases0 E- s0 [" f1 S: i
3.5 Small molecule databases7 @7 J$ d, U+ f2 {% _( W5 h8 I
Chapter 4: Database design: b! v/ x# ]' R* M
Abstract:, ~) L8 V- [/ `' W f! J
4.1 Fundamentals of database design
, c! ~# @! a4 q4.2 ER diagram
2 m* l, m+ s& h) l4.3 Normalization and normal forms( C0 w+ d3 l: O/ O4 j% b, p: T
Chapter 5: Computational T cell vaccine design; Y7 F, C7 _! q8 G3 f
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5.1 Sequence-based methods
; g0 P$ H) r3 q; g$ U; z5.2 Structure-based methods
+ H( k8 ]1 b8 }$ g0 @% Y6 s' j5.3 Broad-based T cell vaccine design
! m1 L; G4 C2 P( c) U7 IChapter 6: Computational B cell vaccine design$ L5 n) i8 s* J) |- B' Q+ S/ X- S8 d$ u, W
Abstract:8 i# G1 P9 Q3 r2 d/ q, p2 T K
6.1 Sequence-based methods
1 [" q; U5 D9 k+ l) k6.2 Structure-based methods. }0 u, h" d- l4 K
Chapter 7: Infectious disease informatics& ~ c" h, n$ ~. {( j
Abstract:. {3 d3 P, i; ]8 j. R" S
7.1 Infectious diseases in history. [8 x0 H8 d- f o' z3 q
7.2 Microbial sequence analysis5 z+ x1 m& x$ y. w8 |) T3 @
7.3 Detecting natural selection in molecular evolution
- m' }' }5 J1 b; `7 E7 |3 wChapter 8: Vaccine safety and quality assessments
+ u0 n1 {' y2 P$ Y* i [- pAbstract:& y, q( c; W$ C9 U# D
8.1 Assessment of ADME/Tox deficiencies4 s: w! ]" o/ |1 N% f) l2 R
8.2 Assessment of allergenicity: X& W& T6 z2 y
Chapter 9: Vaccine adjuvant informatics1 G4 q5 j) A$ y* A5 S) h3 {
Abstract:1 j& E0 d" G% y' M
9.1 Virtual combinatorial library
$ n; r' I, W6 a. a" J; Q2 i9.2 Chemical file formats
9 s# _6 X2 F3 D5 B& {$ J( P, Z; c9.3 Considerations for virtual library design9 {; t3 ]# r7 ?- t8 `. k
Index
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发表于 2016-8-16 12:18:44
发表于 2016-10-9 10:55:32
