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本帖最后由 randomqd 于 2016-8-16 12:20 编辑 6 \0 y4 w& Q f5 Y/ {
1 E. J& V' P6 B- }1st Edition4 R7 a# v, R" f4 e9 j$ z3 o
Authors: Joo Chuan Tong Shoba Ranganathan
+ O+ x0 d: r" S# BElectronic ISBN 9781908818416 Print ISBN 97819075684119 \; m3 F3 Q! y6 e5 \ |
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Description
: v) h# f1 y3 B" f1 ZComputational pre-screening of antigens is now routinely applied to the discovery of vaccine candidates.7 I/ P, x) Q& ]0 a5 r' p4 O, V
Computer-aided vaccine design is a comprehensive introduction to this exciting field of study. The book is intended to be a textbook for researchers and for courses in bioinformatics, as well as a laboratory reference guide. It is written mainly for biologists who want to understand the current methods of computer-aided vaccine design. The contents are designed to help biologists appreciate the underlying concepts and algorithms used, as well as limitations of the methods and strategies for their use. Chapters include: MHC and T cell responses; Immunoglobulins and B cell responses; Scientific publications and databases; Database design; Computational T cell vaccine design; Computational B cell vaccine design; infectious disease informatics; Vaccine safety and quality assessments; and Vaccine adjuvant informatics.
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) G3 @. T5 D7 D: m5 M4 zTable of Contents
3 M6 P& }5 E$ j6 [% B2 C1 @List of figures" \4 e: h3 c* g) W
List of abbreviations
9 h- i6 O1 W/ ?! P' Z" PAbout the authors' u: ?' D0 O* [' I& A- ?
Preface+ K! p' _2 L3 _+ D
Chapter 1: MHC and T cell responses
1 a* Y( h9 v/ V& W3 w ]Abstract:
' u( S5 j8 t7 y3 q1.1 Genetic organization of the MHC$ I! B( o" \: _0 u% n1 G7 u/ Q6 N
1.2 MHC structure& S' l" Q. ]+ z0 W' m
1.3 MHC function
1 j8 E, q1 ?. I$ S1.4 Peptide binding8 L: M; E% X! h7 f" Y
Chapter 2: Immunoglobulins and B cell responses
- l4 Y/ N9 R+ ?, `* q- D5 @% MAbstract:
- \* t0 L# S3 W. E& t7 z" O0 t2.1 Types of immunoglobulins; y# K- X# v4 d J6 g7 k% M/ D2 k
2.2 Immunoglobulin structure
2 N ]' D/ I( }, w3 P: K: P, ?2.3 Immunoglobulin function3 X$ \5 Q6 g3 Q! r, a7 ~
2.4 Antigen binding
4 W$ ^, _9 z) l/ p, q5 l* g: hChapter 3: Scientific publications and databases
4 f8 z9 o6 {$ L. B4 k& q; B+ DAbstract:7 I1 z: R! B, R' \ p
3.1 Bibliographical information9 C M- ^' a- w8 {4 a+ L
3.2 Searching the literature
$ D5 j' Y0 X. h* x5 l: T3.3 General databases containing information on genes and proteins$ t2 u ^) Y0 L8 o
3.4 Immunological databases/ O5 |# ?9 Y+ l5 m' I/ i# F
3.5 Small molecule databases+ `( a1 J% g0 C- r
Chapter 4: Database design6 o" e, J* d4 \& A: d
Abstract:
! b+ F% f# }* \( b% P* d4.1 Fundamentals of database design9 E4 K! l" C3 H @* R3 K4 K- W
4.2 ER diagram" t! d) u& k' c& L7 U. l' L' R
4.3 Normalization and normal forms2 Y1 {; ~( _' H1 ]5 g8 s/ w4 ]
Chapter 5: Computational T cell vaccine design" M, r7 F% H" U7 y1 Z
Abstract:
# r' p3 o# M- r' U* A$ G5.1 Sequence-based methods7 N/ ^& m. h' w
5.2 Structure-based methods
, a, j- _9 d' L2 t5.3 Broad-based T cell vaccine design Y# u- ~- K2 F* `' S0 w% E& ~9 D
Chapter 6: Computational B cell vaccine design* w& b5 ~7 i, t' c
Abstract:: h$ O) a& J2 Y1 m; f6 \
6.1 Sequence-based methods5 `- G5 {' [" G* r
6.2 Structure-based methods9 L/ D5 y4 F) a9 J+ t
Chapter 7: Infectious disease informatics: _9 p! @4 W( @
Abstract:
5 w. A" c9 g6 \7.1 Infectious diseases in history
# q2 ^& x) I* D) Q7.2 Microbial sequence analysis
8 [ ?$ P+ ?0 X" x9 P7.3 Detecting natural selection in molecular evolution
j$ G" M2 ]8 A1 BChapter 8: Vaccine safety and quality assessments3 F" B2 G7 b+ O8 I
Abstract:
0 p6 Q2 o: {8 x/ f- f8.1 Assessment of ADME/Tox deficiencies
. C6 j6 L2 b" K, M4 a8.2 Assessment of allergenicity
6 w8 D0 |+ |! [; uChapter 9: Vaccine adjuvant informatics
) _: c/ o3 y' R) k8 c" LAbstract:9 ] F8 t# ~* v. ]7 J; {$ V8 a
9.1 Virtual combinatorial library
+ o d1 h0 b4 |- f9.2 Chemical file formats3 h/ m& h9 D- J7 z' R. [
9.3 Considerations for virtual library design
% _! \, ?; @( `+ s8 uIndex
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