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本帖最后由 randomqd 于 2016-8-16 12:20 编辑 @- T9 J/ p/ w- [+ V# x. v, t
) S1 s5 |( |. x0 e1st Edition1 l6 U! c7 C2 K
Authors: Joo Chuan Tong Shoba Ranganathan
5 l1 S7 ]' [2 d& T% ]3 [( x3 _. R3 iElectronic ISBN 9781908818416 Print ISBN 9781907568411
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8 R# O% S' ~' y) b+ ?" I' l7 b0 QDescription
4 \2 k; j; {1 `) JComputational pre-screening of antigens is now routinely applied to the discovery of vaccine candidates.( L1 o0 t/ X. w0 M x" [- `
Computer-aided vaccine design is a comprehensive introduction to this exciting field of study. The book is intended to be a textbook for researchers and for courses in bioinformatics, as well as a laboratory reference guide. It is written mainly for biologists who want to understand the current methods of computer-aided vaccine design. The contents are designed to help biologists appreciate the underlying concepts and algorithms used, as well as limitations of the methods and strategies for their use. Chapters include: MHC and T cell responses; Immunoglobulins and B cell responses; Scientific publications and databases; Database design; Computational T cell vaccine design; Computational B cell vaccine design; infectious disease informatics; Vaccine safety and quality assessments; and Vaccine adjuvant informatics.: q) m8 N2 V: t. N% K+ u4 {/ f
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Table of Contents* N. L# f: j6 o; z- A
List of figures1 U' N' x; j3 \/ j6 C+ h0 Q! l
List of abbreviations
; H. ^$ v/ q7 b! M5 tAbout the authors- m" A; f6 N* y) z
Preface
5 j1 x! k' i! e$ X% ^. |$ DChapter 1: MHC and T cell responses( @ _+ k8 t2 w
Abstract:
; D3 Z, O3 Q- E1 M X( I1.1 Genetic organization of the MHC9 h: k* z# t2 Q9 L* P
1.2 MHC structure+ v Y. ^+ W# i+ Q! N: [* B1 ~
1.3 MHC function& z- Q7 E* x: M9 Q# O% j$ w% q6 v9 u
1.4 Peptide binding" p' C0 K4 E, a
Chapter 2: Immunoglobulins and B cell responses
1 c$ u; q( P; m1 y; x. k9 x7 ^) mAbstract:
7 _( C. H4 d3 x4 a; \2.1 Types of immunoglobulins, Z5 x. E; \$ J& S' M
2.2 Immunoglobulin structure8 D! b3 N: n( N+ k3 w R. i$ N9 |" S E
2.3 Immunoglobulin function9 i' F5 f4 m$ X9 Y
2.4 Antigen binding* ]! A8 f! C, s( p
Chapter 3: Scientific publications and databases
* q) k' o' N7 G& x) p6 `Abstract:
( Y; t' f3 L2 _* ~3.1 Bibliographical information# ?. E8 F, \% L# L n' y
3.2 Searching the literature
4 c0 z% |$ d% n: [7 i3.3 General databases containing information on genes and proteins
' p6 d5 Q/ p+ E3.4 Immunological databases8 g2 c: L3 h5 _) P$ I
3.5 Small molecule databases, l o- O: l* Z5 t3 j& U0 X
Chapter 4: Database design, A3 H) L" w4 S7 z8 q/ V
Abstract:4 G1 {2 S* E7 e8 G; I9 @. D
4.1 Fundamentals of database design e1 Q8 C: Y" \% q% ^: g% A
4.2 ER diagram
7 i4 c0 s1 ^2 H( M" B! Y4 N1 j" B6 i4.3 Normalization and normal forms
3 |& ]& G* i4 r6 RChapter 5: Computational T cell vaccine design4 y' m% h( T- M. b# c B
Abstract:
" v. I* ~1 A% c$ r7 d0 k! X5.1 Sequence-based methods
* Z9 Y* ?3 c4 P& g* P3 i5.2 Structure-based methods6 o7 a9 d& k3 o) @: ~! V4 H; s
5.3 Broad-based T cell vaccine design2 j3 w6 m: H6 d' U' Q
Chapter 6: Computational B cell vaccine design
( {" W* K4 t. g" ]8 O- y H# UAbstract:* a8 r! v+ W6 Y, s& _1 L* W1 n
6.1 Sequence-based methods
6 o0 Q1 V( T0 m; P' a# `6.2 Structure-based methods1 t o# B$ w0 \1 `
Chapter 7: Infectious disease informatics& r4 K. O0 d' p, [7 f# i
Abstract:
; x y/ D2 r* ~, m f+ a2 x" g7.1 Infectious diseases in history
1 E8 g, E n! H7.2 Microbial sequence analysis
8 [- V7 ]4 t/ N7 {1 n7.3 Detecting natural selection in molecular evolution$ m" b4 O4 y, e1 G
Chapter 8: Vaccine safety and quality assessments
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8.1 Assessment of ADME/Tox deficiencies
0 ~& Y# P! [) ~- T# G8.2 Assessment of allergenicity
1 K( P( b+ k$ w0 e2 s9 L' i2 q8 u% DChapter 9: Vaccine adjuvant informatics
$ G$ j }8 l- NAbstract:8 Y2 V- y! Y$ Y2 c- ~) _/ @
9.1 Virtual combinatorial library
8 ]$ d: ~& n) Q9.2 Chemical file formats
; E$ t; |. q% h( G# x* |9.3 Considerations for virtual library design( R- I* I6 ]% M0 _* i2 G" f
Index# P w2 {. ?! Y; r$ L
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发表于 2016-8-16 12:18:44
发表于 2016-10-9 10:55:32
