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本帖最后由 randomqd 于 2016-8-16 12:20 编辑 7 T& c) i6 J: r
2 x1 c$ v% j% A1st Edition
; y) H2 W" ]2 t8 q* P* y! DAuthors: Joo Chuan Tong Shoba Ranganathan! G) l" d3 j& n/ i* s% Z" I2 s
Electronic ISBN 9781908818416 Print ISBN 97819075684117 f5 f2 L1 r2 _
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Description& S, o" c6 ~; p+ |( _; A
Computational pre-screening of antigens is now routinely applied to the discovery of vaccine candidates.
D" b, l8 n% @2 hComputer-aided vaccine design is a comprehensive introduction to this exciting field of study. The book is intended to be a textbook for researchers and for courses in bioinformatics, as well as a laboratory reference guide. It is written mainly for biologists who want to understand the current methods of computer-aided vaccine design. The contents are designed to help biologists appreciate the underlying concepts and algorithms used, as well as limitations of the methods and strategies for their use. Chapters include: MHC and T cell responses; Immunoglobulins and B cell responses; Scientific publications and databases; Database design; Computational T cell vaccine design; Computational B cell vaccine design; infectious disease informatics; Vaccine safety and quality assessments; and Vaccine adjuvant informatics.( H3 l- s# l4 a' b$ ]8 B6 l/ X" C
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- W6 i4 U* J9 O0 u) P( d7 q+ KTable of Contents- G1 y4 F% ~, Q2 O; F0 z
List of figures
/ A/ k% O9 b4 l x8 Z) RList of abbreviations0 G. L% V2 d% U! M9 o3 t* Q+ p F$ j
About the authors
& x5 B3 [+ i% HPreface
( ^1 n: j2 A% H ]# Q4 Z% o/ @* YChapter 1: MHC and T cell responses
: ?2 W$ b* P$ I9 vAbstract:* K: X) \8 Y6 g- y, X' z
1.1 Genetic organization of the MHC
' w- t" F$ y5 k J5 w5 B1.2 MHC structure
- c) T' i" n) k0 i* H, G1.3 MHC function
5 G. N) H, s; @& K) A" v1.4 Peptide binding
, O+ u+ b1 B T, j+ f3 OChapter 2: Immunoglobulins and B cell responses9 o" t" _, J$ ~( n
Abstract:) Q' f" r$ r1 b" v3 r5 N2 ]/ ?
2.1 Types of immunoglobulins4 I/ l- q* ?! D$ N! I
2.2 Immunoglobulin structure" M T0 Z# z7 V3 N0 r! U
2.3 Immunoglobulin function
9 ]: @4 @! V+ m, _2.4 Antigen binding/ {- t8 L+ P4 h0 L" _
Chapter 3: Scientific publications and databases
& b0 o+ X2 }7 U7 e, qAbstract:
g: U3 r' j+ R- l) [' @* B3.1 Bibliographical information
1 ]5 _6 ~1 l8 n6 x7 m. g$ F3.2 Searching the literature( @" a) g& ^+ `0 }
3.3 General databases containing information on genes and proteins. Y! a1 U" w" M9 o# B: b/ m
3.4 Immunological databases* Z2 v4 `0 z4 Z7 F' _
3.5 Small molecule databases
& S1 |8 y/ h! m6 B8 HChapter 4: Database design8 @; m( {: H" q, z! a+ `, A
Abstract:) W0 [' P4 `9 r7 Z
4.1 Fundamentals of database design+ Q8 _ E- S ^
4.2 ER diagram
; H: |: \' x9 S0 v$ C) y1 K. Y4.3 Normalization and normal forms
& X. u4 W5 Y. W! d, ZChapter 5: Computational T cell vaccine design) L5 n d# X) y1 X5 b
Abstract:
9 R% M! q* Y! U4 ]5 S! M0 D5.1 Sequence-based methods
7 q# w4 P7 H1 `5.2 Structure-based methods
/ T2 M# [# p9 p( P5.3 Broad-based T cell vaccine design
' B' X3 M4 F# R h& q: nChapter 6: Computational B cell vaccine design/ ?* L) p& T6 N3 Z! |
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6.1 Sequence-based methods& _+ L9 Y% |" J* v& v
6.2 Structure-based methods: N2 e( C# z' t( f. \& L. v
Chapter 7: Infectious disease informatics/ ^& `% @6 K# _5 B: s. Z: n6 |
Abstract:
5 N% C( z4 K+ ` B, Z7.1 Infectious diseases in history) k: O( u# \8 \1 d
7.2 Microbial sequence analysis: S6 j5 D' B6 i* L, h
7.3 Detecting natural selection in molecular evolution
( @; c t' ]) K- W. k- @ _Chapter 8: Vaccine safety and quality assessments
) M4 [4 I( X6 Q% z1 FAbstract:
# o! A0 A( P" j2 j1 G" B8.1 Assessment of ADME/Tox deficiencies
9 m# E4 S- Q: `8.2 Assessment of allergenicity
Q9 Z# z& n9 q! o" a. yChapter 9: Vaccine adjuvant informatics
" Z, R. k& x* vAbstract:
7 q* j) F4 | k- e2 V% y1 E3 n& ]- u6 x9.1 Virtual combinatorial library5 f. D$ x9 Z1 n) z
9.2 Chemical file formats, v& P1 { ]( _' q: ?2 e1 @, Z
9.3 Considerations for virtual library design F+ n0 }, w5 k9 f7 u0 d) O* J
Index% J6 `8 _; o7 z0 D. D6 x$ E1 {- U
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发表于 2016-8-16 12:18:44
发表于 2016-10-9 10:55:32
