|
|
发表于 2015-11-18 09:34:55
|
显示全部楼层
Tespa1 is involved in late thymocyte development through the regulation of TCR-mediated signaling4 @1 ]- @# Z2 }, B* _! n
. N. c' g9 c! B C2 W( w
Di Wang, Mingzhu Zheng, Lei Lei, Jian Ji, Yunliang Yao, Yuanjun Qiu, Lie Ma, Jun Lou, Chuan Ouyang, Xue Zhang, Yuewei He, Jun Chi, Lie Wang, Ying Kuang, Jianli Wang, Xuetao Cao & Linrong Lu
% M% _! b: `& u: K d2 D c4 e8 E$ ~& D: L" V
Signaling via the T cell antigen receptor (TCR) during the CD4+CD8+ double-positive developmental stage determines thymocyte selection and lineage commitment. Here we describe a previously uncharacterized T cell–expressed protein, Tespa1, with critical functions during the positive selection of thymocytes. Tespa1−/− mice had fewer mature thymic CD4+ and CD8+ T cells, which reflected impaired thymocyte development. Tespa1 associated with the TCR signaling components PLC-γ1 and Grb2, and Tespa1 deficiency resulted in attenuated TCR signaling, as reflected by defective activation of the Erk–AP-1 and Ca2+-NFAT pathways. Our findings demonstrate that Tespa1 is a component of the TCR signalosome and is essential for T cell selection and maturation through the regulation of TCR signaling during T cell development.
- o7 R! N# M, `& C* d& z3 E
+ y3 B# Y l& ~0 q4 _; Y3 q9 t鲁教授又出好文章了。 |
|
发表于 2015-11-18 11:04:50
