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Potyviruses differ in their requirement for TOR signalling
Potyviruses are important plant pathogens that rely on many plant cellular processes for successful infection. TOR (target of rapamycin) signalling is a key eukaryotic energy-signalling pathway controlling many cellular processes such as translation and autophagy. The dependence of potyviruses on active TOR signalling was examined. Arabidopsis lines downregulated for TOR by RNAi were challenged with the potyviruses watermelon mosaic virus (WMV) and turnip mosaic virus (TuMV). WMV accumulation was found to be severely altered while TuMV accumulation was only slightly delayed. In another approach, using AZD-8055, an active site inhibitor of the TOR kinase, WMV infection was found to be strongly affected. Moreover, AZD-8055 application can cure WMV infection. In contrast, TuMV infection was not affected by AZD-8055. This suggests that potyviruses have different cellular requirements for active plant TOR signalling.
本文以简报的形式对WMV和TuMV对TOR信号的需求进行了研究，发现RNAi干扰TOR后，WMV的病毒积累量明显下降，而TuMV的积累量未发生变化。同时研究了用AZD-8055处理拟南芥后再接种WMV和TuMV后侵染情况也有所不同。AZD-8055是TOR激酶的抑制子。
http://jgv.microbiologyresearch.org/content/journal/jgv/10.1099/vir.0.000186
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发表于 2017-5-10 23:33:58
